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Biomedical subjects

A A Akhundov

Publications and source records attributed to A A Akhundov.

At least 19 recordsLinked to original sources
PubMed2001

[DNA flow cytometry in the prognostication of certain malignant neoformations].

The study has been concerned with DNA ploidy and its significance for prognosis of different neoplasms. The investigation included 314 patients: primary cancer of the lung (96), head and neck (146) and large bowel (72). Patients received surgery alone or surgery plus either radiotherapy or chemotherapy; they were followed up for 6-20 months. DNA levels were assayed in resected material using an ICP-22 flow cytometer. Diploid and aneuploid cancers were detected in 20.4-53.6 and 43.6-79.6%, respectively. The recurrence rates in cases of aneuploid cancers were more than 3 times those of diploidy (21.0-43.2 and 4.5-14.5%, respectively). Overall 5-year survival in diploid patients was twice that in aneuploid ones. Similarly, survival after surgery alone, preoperative chemotherapy and postoperative radiotherapy among diploid patients was longer than in aneuploid ones. Hence, DNA ploidy examination of tumors is of great informative value in prognosing tumor process and working out individually-tailored approach to treatment.

Adenocarcinoma↗
PubMed1993

[The use of clindamycin and netilmicin for preventing postoperative wound infection in patients with cancer of the upper respiratory and digestive tracts].

Clindamycin (2.7 g/day) and netilmicin (5.6 mg/kg) were used for 6-10 days in 27 patients with laryngeal and oral cancer versus beta-lactam antibiotics and aminoglycosides received by 56 matched patients to prevent infection of the operative wound. Suppuration was observed in 11.1 and 41.4% of the patients, respectively (p < 0.05), the temperature rose over 38 degrees C in 22.2% and 42.9% of the patients, respectively (p < 0.05). The regimens showed similar toxicity. The findings proved high efficacy of clindamycin combination with netilmicin in infection prophylaxis in patients operated on for upper respiratory and digestive tract cancer.

Carbenicillin↗
PubMed1989

[Preanesthetic preparation and induction anesthesia in acute cholecystitis in middle-aged and elderly patients].

Under examination there were 59 elderly and senile patients with acute cholecystitis subjected to emergency operations. It was found that among 3 kinds of initial narcosis smooth course was notable in the phentanyl-sombrevin initial narcosis. The administration of thalamonal-sombrevin initial narcosis results in a certain inhibition of blood circulation, and gives adequate anesthesia during endotracheal intubation. The initial sombrevin narcosis is followed by inhibition of blood circulation and fails to give sufficiently deep anesthesia during intubation of the trachea.

Aged↗
PubMed1986

[Hemodynamic function of patients with diffuse suppurative peritonitis].

A complex examination of central hemodynamics and contracting function of the heart was performed in 85 patients in the preoperative period. It was established that the toxic phase of peritonitis is characterized by the disturbed central hemodynamics and worse contracting function of the myocardium which are found to aggravate the process in the terminal phase and to require intensive prophylactic and curative measures. The authors consider that the shock index and coefficient of the functional state of central hemodynamics can be used in urgent cases for the assessment of the functional state of blood circulation.

Acute Disease↗