The sensitive period for strabismic amblyopia.
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Biomedical subjects
Publications and source records attributed to A A Assaf.
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Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency plays an important biochemical role in the metabolism of the lens. Controversies exist in the literature on the possible association between G-6-PD deficiency and the development of cataracts. The authors present ten patients, aged between infancy and 40 years of age, who were admitted for bilateral congenital or presenile cataracts. These patients had no ocular or systemic disease which might have caused their cataract. The only systemic finding they had was G-6-PD deficiency. Two other patients among the families described suffered from bilateral congenital or presenile cataracts with no G-6-PD deficiency. This deficiency state does not appear to play a role in the production of their cataracts.
Optokinetic nystagmus (OKN) testing is a useful tool for visual assessment. It has been used for assessing visual function in infants, hysterical patients, and malingerers. It is also of value in the diagnosis of disorders of the central nervous system. At present the devices used for the clinical testing of OKN are the OKN drum and OKN tape. A method is presented for OKN testing using an IBM-personal computer or compatible. This method is compared with the other two standard methods.
Three brothers had bilateral retinoblastoma: one other sibling, a girl, had normal eyes. The parents were second cousins once removed. The father's right divergent eye, 'amblyopic' from childhood, showed a large atrophic patch in the macular area, probably a spontaneously resolved retinoblastoma.
Six hundred forty-three patients had retinal detachment surgery during 81/2 years; 17.6% were under the age of 30 years. Analysis of this group of patients showed that males were more commonly affected than females (68%). Trauma was the most frequent cause, reported in 40% of cases. Dialysis was the commonest retinal break, occurring in 51% of patients, and 73% of these occurred in the inferior temporal quadrant. In patients with a history of trauma, the type of the retinal break produced and operative success was related to the severity of ocular damage, with more successful outcomes in nontraumatic cases and fewer of these in cases of ocular perforation.
Of 2649 patients with strabismic amblyopia who attended clinics between 1941 and 1978, 1904 patients were reviewed. Of these, 115 patients had transfer of fixation after occlusion. These were analysed according to the type of transfer of fixation and relation to occlusion and age. The period of maximum sensitivity to short periods of occlusion extended to 18 months, declining to about 30 months of age. Sensitivity to occlusion reaches low levels about the age of 5 to 51/2 years, though it is still present to some degree, especially in patients with relatively good visual acuity of 6/36 or better. The upper limit of the sensitive period was found to be about the end of the seventh year of age.