PubMed Health⌕ Search

Biomedical subjects

A A Azarashvili

Publications and source records attributed to A A Azarashvili.

At least 19 recordsLinked to original sources
PubMedDate not supplied

Studies of the role of the brain cholinergic system in the mechanisms of dissociative learning.

Rats were trained to make conditioned food reflex excursions in two states: in normal conditions and on a background of treatment with pharmacological agents producing dissociative states. A number of cholinergic substances were completely interchangeable in dissociative learning; anticholinergic compounds efficiently neutralized the ability of cholinergic substances to produce dissociative states; muscarinic cholinoreceptors played the leading role in production of the dissociative state.

Animals↗
PubMedDate not supplied

[The use of dissociated learning in the study of the mechanisms of memory].

The review is dedicated to description of the phenomenon of dissociated learning. The distinct criteria which discriminate this phenomenon from those similar in appearance are presented. The experimental procedure is described: habituation of an animal, a device for dissociated learning, and the mode of determination of the necessary dose of a drug and injection time. Different versions of dissociated learning which can be gained using the same device, as well as methodical recommendations for researchers in the field of studying this phenomenon. Analysis of the author's data shows that the use of dissociated learning can be promising for studying mechanisms of learning and memory.

Animals↗
PubMedDate not supplied

[Complex perception of stimuli during conditioning].

The review concerns the effects of a variety of stimuli on the reproduction of conditioned reflexes. By the literature data, during conditioning of any type, besides the single stimulus intentionally applied by an experimenter as a conditioned one, an animal perceives the whole complex of stimuli (acoustic, visual, olfactory, algesic, and other exteroceptive, proprioceptive, and interoceptive stimuli), including those of the environment and time of the day during training. Many of these stimuli are essential for the reproduction of the acquired habit. The complex of stimuli that act on an animal during the reproduction should in all parameters correspond to that perceived by the animal during training. If the complexes differ at least in one stimulus, the reproduction of the reflex may fail.

Animals↗
PubMedDate not supplied

[The effect of iproniazid on biogenic amine levels, elaboration and reproduction of alimentary conditioned reflexes].

A study of the action of iproniaside on alimentary conditioning has shown that even its small doses (25 mg/kg) disturb the formation of the conditioned reaction, while large doses (200-250 mg/kg) do not disturb the reproduction of the conditioned reaction elaborated and stabilized before the administration of the drug. Hence, dissociated learning with the use of iproniaside is impossible. The applied doses of iproniaside result in an increased level of biogenic amines in the dopaminergic nigro-neostriate and reticulo-septal brain systems. It is therefore assumed that the effects of iproniaside on learning are due to its influence on the level of the CNS biogenic amines.

Animals↗
PubMedDate not supplied

[Ability of reversible cholinesterase inhibitors to support dissociative learning].

In the experiments on rats performed to study dissociated learning it was found that reversible inhibitors of cholinesterase are interchangeable. It was shown that neutralization of the behavioral effect of cholinesterase inhibitors may be induced most successfully by combined administration of M- and N-cholinergic blocking agents.

Animals↗
PubMedDate not supplied

[Development of a dissociated state in the rat after administration of carbacholine into the hippocampus].

Food-procuring conditioned reaction was elaborated in rats. A single injection of carbacholine into the dorsal area of the hippocampus elicited prolonged (for several days) stable amnesia, during which elaboration of a second habit in the same animals proved possible. After cessation of the agent action, the initially elaborated conditioned reaction recurred. The obtained results allow to interpret the amnesia elicited by injection of carbacholine into the hippocampus as a dissociated state.

Amnesia↗
PubMedDate not supplied

[Role of the cholinergic and monoaminergic systems of the brain in dissociated learning].

Rats placed in an experimental chamber, were trained to perform two dissociated reactions; the one--in a normal state, the other--after administration of physostigmine. Then the animals were divided into 10 groups and in each group the performance of the elaborated conditioned reflexes was tested after administration of the substances influencing cholinergic and monoaminergic brain systems. It is shown that the dissociation state after physostigmine administration is due to the influence of this substance on the cholinergic brain system. The increase of biogenic amines content in the central nervous system leads to the appearance of dissociation after a smaller dose of anticholinesterase. This seems to reflect a modulating influence of monoaminergic brain systems on the cholinergic system during performance of the dissociated reactions.

Acetylcholine↗