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Biomedical subjects

A A Belyĭ

Publications and source records attributed to A A Belyĭ.

14 recordsLinked to original sources
PubMed1986

[Age-related characteristics of the functional state of kidneys (radiorenography data)].

Renal function of 91 healthy subjects aged 18-91 has been evaluated at radionuclide renography with the use of 131I-Hippuran. Renal excretory function, effective renal plasma and blood flows were found to decrease annually by 0.09 ml/kg in ageing men and by 0.08 ml/kg in women. The use of new indices may be useful for evaluation of renal blood circulation, especially during hypo- or hypervolaemia is proposed. These are the index of renal circulation efficiency and the mean time of circulating blood volume transfer through renal blood vessels.

Adolescent↗
PubMedDate not supplied

[Age-related characteristics of the pharmacokinetics of acetylsalicylic acid].

Acetylsalicylic acid pharmacokinetics was studied in young, elderly and old patients after a single oral administration in a dose of 14 mg/kg. The pharmacokinetics data may be formalized by means of the one-compartment model with absorption. Constants of absorption and elimination, total clearance value are decreased with age. The half-life in elderly patients was 6.19 hrs, in old patients 12.2 hrs and in young patients 4.47 hrs. In elderly and old patients the area under the pharmacokinetic curve increased. The ability of serum proteins to bind salicylates reduced during ageing. The pharmacokinetic model was used for optimization of treatment with acetylsalicylic acid of elderly and old patients.

Administration, Oral↗
PubMedDate not supplied

[Utilization of the pharmacokinetic parameters of acetylsalicylic acid for optimizing its use with people of different ages].

Nomograms for application of acetylsalicylic acid in persons of different age are presented. The nomograms are based on pharmacokinetic parameters of acetylsalicylic acid with regard to the age. Proceeding from the known constants of absorption and elimination, the nomograms are made use of to screen the loading and maintenance doses, to determine the time of administering the first maintenance dose and the maximal amount of the drug in the body, which was built up as a result of the use of the accepted treatment schedule. While using the nomograms one should be guided by the known therapeutic dose and the dosage intervals or by the therapeutic or maximal allowable dose. The nomograms are unsophisticated, fairly convenient, and help determine the optimal regimen of the use of acetylsalicylic acid in persons of different age.

Adult↗