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Biomedical subjects

A A Bezzubov

Publications and source records attributed to A A Bezzubov.

18 recordsLinked to original sources
PubMedDate not supplied

[Hygienic evaluation of genotoxic effects during artificial air ionization].

The study examined the potential genotoxic activity and the impact of artificial air ionization on lifespan. Experiments on Drosophila melanogaster demonstrated that exposure of the lung to negative (5 x 10(4), 5 x 10(5), and 10(6) ion/cm3) and slight positive (5 x 10(4), 5 x 10(5), and 10(6) ion/cm3) airoions generated on the electrodes at direct-current voltage failed to increase the frequency of dominant lethal mutations in the gametes and to affect the life-span of male flies. Exposure of the flies to deionized air increased the rate of early embryonic lethal mutations.

Air Ionization↗
PubMedDate not supplied

[Metabolism of S-methylmethionine (vitamin U) in animals].

Metabolism of S-methylmethionine (vitamin U) has been studied in rats. Biotransformation of this compound actively proceeds in the liver, kidneys, and digestive tract. Metabolism of S-methylmethionine in the liver and kidneys was found to proceed both via methylation of homocysteine with the formation of methionine and via enzymatic hydrolysis to dimethylsulfide and homoserine. In the digestive tract, only the activity of S-methylmethionine-sulphonium hydrolase was found. The physiological role of the metabolic routes under study is discussed.

Animals↗
PubMedDate not supplied

[S-methylmethioninesulfonium hydrolase activity in plant and animal tissues].

A gas-chromatographic technique is proposed for determining the activity of S-methylmethionine-sulphonium-salt hydrolase in homogenates of plant and animal tissues. The enzyme was found in flowers, leaves and fruits of different plants. The enzymatic hydrolysis of S-methylmethionine was found for the first time in different organs of animals, liver and kidneys possessing the highest enzyme activity.

Animals↗
PubMedDate not supplied

[S-methyl methionine (vitamin U) pharmacokinetics in rat and man].

S-methyl methionine was shown to be rapidly absorbed, accumulated in the liver and kidneys and actively assimilated by the organisms of rats and man. Some constants of pharmacokinetics of different optical forms of S-methyl methionine were determined. The predominant use of L-form was found. The concurrent administration of D- and L-forms stimulates processes of D-form assimilation.

Absorption↗
PubMedDate not supplied

[Farnesol in brandy].

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Alcoholic Beverages↗
PubMedDate not supplied

[Gas chromatographic determination of S-methylmethionine (vitamin U) in plants].

A quantitative gas-chromatographic method to assay S-methyl methionine (vitamin U) in plants has been developed. The method is based on the disintegration of S-methyl methionine in the alkaline medium to form equimolecular quantities of dimethyl sulphide and homoserine. Dimethyl sulphide is distilled in the flow of an inert gas (nitrogen) and trapped in the toluene trap cooled to--78 degrees. The toluene solution containing dimethyl sulphide and carbon tetrachloride as an inner reference is analyzed in a gas chromatograph. Optimal conditions for the reaction to form 91.1% dimethyl sulphide from S-methyl methionine sulphonium chloirde at concentrations ranging from 0.1--5.0 mg% have been established. The standard error of measurements is +/- 1.5%.

Chromatography, Gas↗