[Significance of diagnostic characteristics of a test in choosing a method for diagnosis of Helicobacter pylori infection].
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Biomedical subjects
Publications and source records attributed to A A Budzinskiĭ.
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The group of 89 patients was examined, 63 of them suffered by a duodenal ulcerative disease, 11--by gastric ulcerative disease and 15--by chronic gastritis. It was conducted the comparison of the following indices: sensitivity, specificity, relationship of probability and diagnostic efficiency of histological, cytological methods, urease and respiratory tests, method of polymerase chain reaction, qualitative and quantitative definition of antibodies of the class IgG in serum blood to H. pylori by a method of enzyme immunoassay and Western-blot for H. pylori infection diagnostics was carried out. The results show that in choice of a diagnostic method of infection H. pylori it is better to use such characteristics as sensitivity and specificity, which more objectively reflect the diagnostic possibilities of each test.
The article is based on an analysis of observation of 853 patients with complicated forms of cholelithiasis. The average age of patients was 73.5 years, two thirds of them had critical coexistent diseases. The system of treatment proposed by the authors allowed achievement of good results (lethality is less than 5%) while the methods of treatment generally accepted in surgical practice is followed by higher lethality achieving 40%. The work analyzes errors and complications of endoscopic decompressing operations and gives recommendations for their prevention.
The authors had 158 patients with acute block of the terminal part of the choledochus under observation. According to the clinical course, a biliary, pancreatic, and mixed forms were distinguished. The emergency diagnostic program was made up of ultrasonic examination, esophagogastroduodenoscopy, ERCP, and laparoscopy. The cause of the block of the terminal choledochus was choledocholithiasis in 104 patients, papillitis and microcholedocholithiasis in 36, and ++choledocholithiasis and stenosis of the major duodenal papilla in 18 patients. Acute block of the major duodenal papilla was found in 76 and acute block of the intramural part of the choledochus in 76 patients. The mixed form prevailed in the first and the biliary form of hypertension in the second. Operations (cholecystectomy, choledocholithotomy with external or internal drainage of the choledochus) were performed on 42 patients, the postoperative fatality rate was 9.7%. Emergency EPST and extraction of concrements was undertaken in 116 patients. Increase in the clinical picture of acute cholecystitis and destructive pancreatitis after EPST called for operative interventions on 21 patients. The lethality rate after EPST performed for acute block of the terminal choledochus was 6.1%.
The sensitivity and specificity of ultrasound investigation (USI) and x-ray methods of indirect and direct contrast studies of the biliary system in the diagnosis of cholecysto- and choledocholithiasis were compared by a blind control method. USI was shown to be superior over all x-ray contrast methods in the diagnosis of cholecystolithiasis. The diagnosis of choledocholithiasis usually requires the use of x-ray methods among which preference should be given to endoscopic retrograde cholangiography as the most informative method permitting simultaneous intervention on the major duodenal papilla.
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