Biomedical subjects
Publications and source records attributed to A A Buganov.
The authors studied immune state in individuals engaged in construction materials production, in accordance with presence or absence of arterial hypertension and hypercholesterolemia. Findings are depressed nonspecific resistance parameters and T-cell reactions in immune state.
The authors studied immune state of workers producing building materials, in accordance with the production features. Occupational hazards were proved to change contents and ratio of immune lymphocytes, to suppress the workers' nonspecific resistance.
Studies of cardiovascular risk factors among able-bodied population of Far North revealed that these factors are highly prevalent and differ in incidence according to occupational group and previous residence region.
Epidemiologic examination of able-bodied population in Far North revealed time-matched averages and confidence intervals for systolic and diastolic blood pressure, pulse rate in newcomers, individuals with normal and high blood pressure. Those results enable to diagnose arterial hypertension by time-related changes in blood pressure during epidemiologic studies.
The authors demonstrate 24 hours' profile of blood pressure for able-bodied healthy population of Far North. The workers and office staffers appeared to have identical blood pressure profiles that are characterized by lower decrease of nightly blood pressure, prevalent morning and two-humped biorhythm.
The frequency of arterial hypertension among non-native able-bodied unorganized population of Yamalo-Nenets Autonomous Okrug was studied. Mean population index of the frequency was 31.0%. Important factors which promote arterial hypertension are excessive body mass, age, period of living in the Far North, psycho-emotional stress, unsatisfactory level of adaptation and its failure, dislipidemia.
The relation of 24-hour blood pressure monitoring indices with degree of target-organs damage in 114 non-natives of the Far North who had no previous antihypertensive treatment was studied. It was found out that mean BP influences on developing of chronic forms of vascular brain pathology, microalbuminuria degree correlates with pulse BP level, development of hypertensive retinopathy is associated with excessive variability of day BP.
The study of cause-consequence relationship between factor of nutrition and such predictors of atherosclerosis as arterial hypertension, dislipoproteidemia and excessive body mass determines the importance, expediency and possibility of early primary prophylaxis of risk factors of cardiovascular diseases among children and adolescents on population level.
Nutrition of non-natives in the Far North is of European character but also has the features of native population national cuisine. Because of these factors, there are some peculiarities in formation of blood lipid spectrum in non-natives. In particular, in population of non-native women of Yamalo-Nenets Autonomous Okrug, the fat component of 24-hour diet influenced most, carbohydrate component had less importance.
Real nutrition of non-natives in the Far North is misbalanced in contents of major nutrients, vitamins and minerals and has atherogenic orientation.
Diovan (valsartan) in dose 160 mg/day was given to 20 patients with mild and moderate arterial hypertension living in the Far North. The treatment was carried out during 4 weeks and its influence on circadian BP, lipid, carbohydrate and water-salt exchange was studied. Antihypertensive activity and tolerance to the medication were also analyzed.
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The actual problems of health-keeping in children and adolescents living in high latitudes are analyzed. The data on morbidity and spreading of risk factors of chronic non-infectious diseases in adolescents aged 14-17 living in the Far North are presented.
Conducted in Gelenjik resort, treatment of arterial hypertension in gas workers of Far North appears quite effective, in spite of different geographic zone. 14-days stay in the resort place with approved complex of therapeutic measures induces stable decrease of systolic and diastolic blood pressure.
Screening examination of pupils in 13-16 ages of Nadym by method of 24h.dietary interrogatory detected complex vitamin insufficiency and imbalance of mineral composition of juveniles diets. It was showed necessity of correction of pupils nutrition which are living in the conditions of the Far North.
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In capable male population (age 20-59 years) developing oil and gas extraction in the Western Siberia the incidence of arterial hypertension reached 14.1%. Wide introduction of preventive programs in the extreme conditions of labour helped to normalize blood pressure in every second patient and to maintain health in migrants from other regions.