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Biomedical subjects

A A Cinotti

Publications and source records attributed to A A Cinotti.

At least 19 recordsLinked to original sources
PubMed1988

Use of an angiotensin converting enzyme inhibitor in ocular hypertension and primary open-angle glaucoma.

We studied the effects of a new topical angiotensin converting enzyme inhibitor, SCH 33861, in lowering intraocular pressure in 20 patients with ocular hypertension or primary open-angle glaucoma. In a double-masked, four-way crossover study with placebo and timolol, SCH 33861 was well tolerated and effective in lowering intraocular pressure. The magnitude of the drug's effect in lowering intraocular pressure was less than that of timolol 0.5%.

Adult↗
PubMed1988

Control of intraocular pressure in glaucomatous eyes after extracapsular cataract extraction with intraocular lens implantation.

Two hundred sixty eyes of 195 patients having extracapsular cataract extraction (ECCE) with insertion of a posterior chamber intraocular lens were studied retrospectively. Of these cases, 160 eyes had preexisting glaucoma while 100 had no ocular pathology except for cataract. Intraocular pressure decreased significantly after ECCE in both groups and slowly returned to baseline within two years. The average postoperative visual acuity was better in the control group than in the glaucoma group. Patients with glaucoma were controlled with less medication after surgery. We believe that ECCE with insertion of a posterior chamber intraocular lens can be safely performed in glaucoma patients and has a beneficial effect on the control of glaucoma.

Aged↗
PubMed1988

Systemic effects of intraocular epinephrine during cataract surgery.

This paper examines the effects of intraocular epinephrine on systemic blood pressure and heart rate during cataract surgery. Sixty-two patients were studied, all of whom received an intraocular infusion of approximately 200 to 300 mL of balanced salt solution with 0.5 mL of epinephrine 1:1000. There was no statistically significant change in blood pressure or heart rate during the time of epinephrine administration. Electrocardiogram monitoring during surgery showed no changes. We believe that dilute concentrations of epinephrine administered during extracapsular cataract extraction pose little threat of systemic toxicity.

Aged↗
PubMed1986

Neodymium:YAG laser therapy for pseudophakic pupillary block.

Pupillary block occurred in six patients with anterior chamber intraocular lens implants. After medical therapy failed, the Nd:YAG laser was used to break the hyaloid face in the pupillary and iridectomy apertures. Iridotomies were also produced at the sites of bulging iris. Following laser treatment the anterior chambers deepened and there were no further signs or symptoms of pupillary block. The Nd:YAG laser proved to be a useful treatment for pseudophakic pupillary block.

Aged↗
PubMed1979

Evaluation of indications for cataract surgery.

The large number of cataract operations performed in the United States annually has raised questions as to the indications and methods of documentation. The criteria designed for the Physicians and Surgeons Review Organization (PSRO), the thrust of second opinions, and an evaluation of the types of cataracts producing visual impairment are discussed. The contralight test of Junker is demonstrated as a means of determining the effect of cataracts on visual acuity and could be used as an indicator of the need for surgery.

Adolescent↗
PubMed1978

Definitive treatment of congenital larcrimal sac fistula.

The procedure we describe is believed to be a rational and effective approach to the rare but preplexing problem of congenital lacrimal sac fistula. The procedure is based on the principles of: (1) definite location of the lacrimal sac for protection of canaliculi and sac through probe insertion; (2) fastidious dissection of the tract to its base; and (3) positive testing of the suture and sac site for leakage.

Adolescent↗
PubMed1977

Ultrastructural abnormalities in a Marfan's syndrome lens.

The surface ultrastructure of the posterior of the Marfan's syndrome lens was studied by scanning electron microscopy. All aspects of the architecture and construction of the capsule, the zonules and their insertions, the epithelium, and the lens fibers showed a sharp deviation from normal. The capsular fibrils were abnormally large and grossly granular. The zonular fibrils, similar in size and granularity to those of the capsule, contained numerous large aggregates and showed a lack of parallel orientation. The epithelial cells displayed a coarser than normal surface granularity and a lack of regularity of form and orientation. The cortical and nuclear lens fibers displayed a relatively normal surface pattern but showed poorly defined borders and interdigitating processes.

Adult↗
PubMed1976

Tomographic measurements of in vivo cataracts by slit-lamp photography.

A practical method for detecting in vivo cataracts has been developed using a commercially available slit-lamp camera and by utilizing a measuring grid photographic technique. The basis of the method is to photograph a series of slit-beam sections through a lens at varying angles to the optic axis. The areas of opacity show up as localized regions of light back-scatter where the opacities intersect the path of the beam. A set of measuring grids compensated for angle distortion have been prepared. These are superimposed on the appropriate photograph. By taking a sufficient number of sections through a cataractous lens, a tomographic representation of the opacities can be constructed using a lens map. An example of the procedure of three-dimensional mapping is presented using actual lens pictures. The photographic parameters used in this method are explained in detail. The method achieves the goals of ease of use, reproducibility, and applicability to research and clinical studies.

Aged↗
PubMed1976

Surface ultrastructure of the human lens capsule and zonular attachments.

The ultrastructure of the human lens capsule and zonular attachments was studied using scanning electron microscopy. The capsule was found to have two components; an organized mass of undulating, roughly parallel fibrils and a granular component. The undulation of the capsular surface and filament organization was much less evident near the anterior pole. The zonules were also found to be fibrillar and easily distinguishable from the capsular network. The three-dimensional aspects of the association between the zonules and the capsule as seen in these studies appear to meet the requirements of accommodation.

Humans↗
PubMed1976

Causes for removal of the eye: a study of 890 eyes.

This study is a review of 890 cases of eye enucleations performed over a period of 22 years. The major cause for enucleations was trauma, accounting for 39.7% of the eyes enucleated. Chronic inflammatory diseases accounted for 22.1%, glaucoma for 11.5% and tumours for 9.2% in this group. Retinal diseases were responsible for 5.5% of the eyes; vascular occlusion for 5%; and miscellaneous causes for the remaining 7%. Injuries were everyday tools and small flying missiles caused most of the trauma. Previously planned surgical operations accounted for 15% of the enucleations. Forty-eight of these eyes had epithelial or fibrous downgrowths resulting from inflammation, secondary glaucoma, and phthisis bulbi. A more careful selection of cases and better surgical techniques might significantly lower these statistics. Also, vascular occlusion should be given a high level of suspicion in all intractable cases of glaucoma of unexplained etiology. As a general rule, enucleations should not be performed because of the suspected presence of sympathetic ophthalmia.

Adolescent↗
PubMed1975

Iris photocoagulation therapy of aphakic pupillary block.

Five patients who underwent uneventful cataract extraction developed flat anterior chamber (AC) secondary to pupillary block, 2 1/2 to 4 weeks postoperatively. None had a wound leak. After drug therapy had failed to restore the AC, iris photocoagulation was performed. Four eyes were treated with a xenon-arc photocoagulator, and one with both a portable xenon-arc unit and an argon laser. The AC deepened immediately and permanently in all cases. No complications occurred, and visual acuity was good. Iris photocoagulation with a xenon-arc unit is a valid alternative to intraocular surgery in therapy for flat AC that is caused by aphakic pupillary block in patients in whom medicinal therapy fails and no wound leak is present.

Aged↗