Biomedical subjects
Publications and source records attributed to A A Cordero.
The authors study three clinical cases of Pacinian neurofibromas. All of them were located in the fingers. A bibliographic review was performed. The morphologic, clinical and histological features are reviewed and stressed its benign behavior and special localization.
A patient of 4 years of age, male is presented, that suffered from generalized pustulous psoriasis. The small response to prednisone and the aggravation of the symptomatology motivated the use of etretinate, in the dose of 1 mg/kg/day during six months obtaining the remission. Two years later he was seen again having minimal lesions of periumbilical psoriasis, observing delay in the growth, and in the radiological exam: periostic separation in the inferior part of femur, modeling alteration of the metaphysis, diffuse demineralization, slender bone, and a bone age of one and a half year. The authors advise over the necessity of controlling children that must receive etretinate, with clinic and periodic radiological exams.
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Nevus comedonicus is and uncommon abnormality. Clinical and histopathologic characteristics are described. Also the histogenesis is discussed. Eleven new cases are reported. A tretinoin solution or cream produced excellent improvement.
A group of patients with acne rosacea was treated with 5 percent benzoyl peroxide acetone gel for four weeks and then with 10 percent benzoyl peroxide acetone gel for an additional four weeks. A parallel group of patients was treated with a matching placebo (acetone gel vehicle). At the end of the first four weeks of treatment the dropout rate due to lack of improvement was 23 and 63 percent for benzoyl peroxide acetone gel and placebo, respectively. Benzoyl peroxide acetone gel was superior to placebo with respect to improvement in the overall severity of the lesions when judged by photographs, and by reduction of erythema, papules, and pustules. Results after treatment with benzoyl peroxide acetone gel were better during weeks five to eight than during weeks one to four for all lesions except telangiectasia. Benzoyl peroxide acetone gel was superior to placebo when the overall responses were compared. In addition, the benzoyl peroxide acetone gel-treated group, but not the placebo-treated group, showed a significantly better response during weeks five to eight compared to weeks one to four.
Thirty-six patients were treated for single or multiple warts by intralesional injection of bleomycin sulfate (Blenoxane) at the base of the wart. The dose varied according to the size of the lesion and ranged from 0.2 to 0.8 mg per injection, up to a maximum total dose of 2 mg. The cure rates were as follows: 67 percent in plantar warts; 82 percent in ungual warts; and 80 percent in warts located elsewhere. The cure rate for all patients was 75 percent. The drug was well tolerated and the procedure readily accepted by the patients.
Twenty eight patients with various dermatological conditions were treated orally with the new aromatic derivate of retinoic acid, Ro 10-9359. The initial average dose was 48,3 mg/day and the maintenance dose was 26,6 mg/day. Duration of treatment ranged between 3 to 6 months. Evolution of erythema, infiltration and hyperkeratosis showed changes statistically significant (p < 0,05) and excellent to good results were obtained in 23 out of the 28 treated patients. On the basis of this study it is concluded that Ro 10-9359 is a promising drug for the treatment of several skin diseases, specially ichthyosis, Darier's disease, oral lichen planus, erythrokeratoderma variabilis and psoriasis. No serious side effects were reported; dryness of the lips, scaling of palms and soles, pruritus and thinning of the skin were the most common. In no case treatment was discontinued due to side effects. Laboratory controls did not show deviations from the normal values.
Punctate porokeratosis is not usually recognized as a clinical form of porokeratosis of Mibelli. Two cases of punctate porokeratosis are presented. Other punctate lesions with similar clinical features which should be considered in the differential diagnosis are discussed.
Two personal cases of Non venereal Lymphangitis of the Penis are presented in 23 and 28 men, and 38 cases from the literature are reviewed. This benign self-limiting condition is not too well known among dermatologists and urologists. The clinical changes, in particular noted by palpation are characteristic: painless firm cartilaginous cord freely movable behind the corona of glans penis in the coronary sulcus. The inguinal lymph nodes are not involved. The microscopic features in one of our patients demonstrated that the lesion results from cystic dilatation of secondary organization of the thrombus. The etiology is unknown. We favour the mecanical trauma as an important factor based on excessive sexual activity of the patients.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.