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Biomedical subjects

A A Dzizinskiĭ

Publications and source records attributed to A A Dzizinskiĭ.

At least 19 recordsLinked to original sources
PubMed2006

[Cavinton forte treatment of cerebral vascular insufficiency in patients with coronary heart disease and arterial hypertension].

Using 48-h Holter monitoring of ECG and ambulatory blood pressure monitoring, 28 patients (13 men, 15 women, mean age 66.6 +/- 7.7 years) with cerebral vascular insufficiency of the I-II stage in combination with chronic coronary heart disease and essential arterial hypertension have been examined. Quantitative parameters of myocardial ischemia episodes and hypotension conditions were calculated and compared before the beginning (the first 24 h of monitoring) and during taking the daily dose of 30 mg of cavinton forte (the second 24 hours of monitoring). The distribution of ischemia and hypotension episodes in the periods of the maximal supposed effect of the drug was analyzed. Cavinton forte neither contributes to the manifestation and average frequency of myocardial ischemia episodes nor influences parameters and the character of short-term arterial hypotension episodes. The drug reduces quantity and duration of blood pressure nocturnal fall. It is concluded that initial cavinton forte treatment of cerebral vascular insufficiency in patients with chronic coronary heart disease in combination with arterial hypertension is safe when combined with hemodynamically active antihypertensive and antiischemic therapy.

Aged↗
PubMed2005

[Cardiac arrhythmias during an elective cholecystectomy].

The paper presents systemized literature data on cardiac arrhythmias (CA) associated with cholecystectomies. The authors present an analysis of CA in 101 patients with chronic calculous cholecystitis (CCC), registered before, during and after an elective cholecystectomy (the surgery was performed either through laparotomy or using endovideosurgical technique). The study revealed that cholecystectomy, especially laparatomic one, bore an arrythmogenic effect. Additional predictors of dangerous CA associated with surgical treatment of CCC, were presence of sinus tachycardia, bradycardia, ciliary arrhythmia, changes in the variability of heart rate, and preoperative heart enlargement.

Adolescent↗
PubMed2004

[Clinical course of acute myocardial infarction and left ventricular function in long-term epidural analgesia].

The study of 76 patients with macrofocal myocardial infarction (MI) evaluated effects of epidural and standard analgesia on pumping capacity of the left ventricle (LV) and clinical course of MI. The study group consisted of 37 patients exposed to long-term morphine-clopheline epidural analgesia. In the control 39 patients analgesia was induced conventionally (intravenous injection of morphine). Both groups received the same routine treatment. Long-term morphine-clopheline epidural analgesia noticeably improves pumping LV function and clinical course of MI.

Analgesia, Epidural↗
PubMed2004

[Effect of long-term epidural analgesia and nitroglycerin infusion on formation of necrosis zone and clinical course of myocardial infarction].

AIM: To study effects of long-term morphine-clofelin epidural analgesia and infusion of nitroglycerin on formation of the necrosis focus and the clinical course of acute myocardial infarction (MI). MATERIAL AND METHODS: Ninety patients were examined within the first 12 hours of anterior macrofocal MI. Forty six patients of the study group received long-term morphine-clofelin epidural analgesia and nitroglycerine infusion within the first 24 hours of the disease. Forty-four control patients were anesthetized conventionally with intravenous morphine. Development of MI was assessed with electrocardiotopography and dynamic examination of MV CK in the blood serum. RESULTS: The degree and area of the myocardial lesion were initially similar in the study and control groups. These indices were less in dynamics in the study group. On MI day 5 and 10 myocardial necrosis zone significantly diminished in the study group. CONCLUSION: Long-term epidural analgesia and nitroglycerin infusion provide effective analgesia, localizes the ischemic and necrotic focus, have a good effect on hemodynamics and improve a MI clinical course.

Analgesia, Epidural↗
PubMed2002

[Arterial hypertension in patients with undifferentiated adrenal tumors].

AIM: To study clinical and laboratory manifestations of hormonal activity in hypertensive patients with undifferentiated adrenal tumors. MATERIAL AND METHODS: 40 patients (19 males and 21 females aged 16-60 years) with undifferentiated adrenal tumors were examined. They were treated surgically. The results of the examination were compared with histological evidence on the resected adrenals. Clinical and laboratory signs of hormonal activity of the tumor were ascertained. RESULTS: Clinical symptoms in patients with adrenal tumors differed from those of typical symptoms of Icenko-Cushing, Cohn syndromes, pheochromocytoma. Hypertension in patients with cortical tumor may arise because of high synthesis of hydrocortisone, in patients with medullary tumor--of catecholamines. However, the level of hormones was not high enough for development of classic syndromes. That's why these tumors were named undifferentiated. CONCLUSION: Adrenal cortical tumors have signs of mixed androgeno-mineral-glucocorticoid activity. In medullary adrenal tumors hypersecretion of catecholamines is associated with cortical hyperfunction.

Adolescent↗
PubMed2001

[Cerebrogenic cardiac arrhythmia in patients with organic brain diseases of nonvascular genesis].

Cardiological examination covered 115 patients (79 males and 36 females aged 16-44 years) with organic brain pathology of nonvascular genesis: epilepsy (n = 51), sequelae of closed craniocerebral trauma (n = 37) or cerebral inflammation (n = 27). The control group consisted of 15 healthy subjects. It was found that patients with brain diseases have a variety of cardiac rhythm and conduction disturbances which occur much more often than in the control group (p < 0.01). Cardiac arrhythmia was encountered most often in epileptics and patients with complications of closed craniocerebral trauma (96.1% and 70.3%, respectively). Rates of cardiac arrhythmia and conduction disorders in patients with brain diseases correlated with frequency of epileptic fits and severity of organic alterations in the brain. The pattern of rhythmic and conduction disorders was formed according to dysfunction of suprasegmentary vegetative centers with prevalent activation of the sympathetic or parasympathetic autonomic nervous system. Cardiac arrhythmia and related negative feelings deteriorate "quality of life" in patients with brain pathology that's why it is necessary to detect and treat them early.

Adolescent↗
PubMed1999

[The detection of early disorders of the heart pumping function in patients with ischemic heart disease by using stress Doppler echocardiography].

AIM: To determine potential of loading Doppler echocardiography (DECG) in detection early, subclinical dysfunction of left ventricular pump capacity in patients with ischemic heart disease. MATERIALS AND METHODS: Systolic and diastolic functions of the left ventricle (LV) before and during transesophageal electrocardiostimulation (TEECS) were assessed in 65 patients (55 males and 10 females, mean age 47 +/- 1.3 years) with effort angina functional class I, II and III and 25 control patients. RESULTS: Initial LV systolic function did not differ from control values. In the course of TEECS, LV systolic function declined in accordance with severity of angina and stimulation frequency. Initial LV diastolic function was reduced only in patients with angina class II and III. These changes were more pronounced in the course of TEECS. CONCLUSION: Stress Doppler echocardiography is a reliable tool in detection of early, preclinical impairment of cardiac pump function in patients with ischemic heart disease.

Angina Pectoris↗
PubMed1991

[The effect of prolonged morphine epidural analgesia on the clinical course and size of the necrotic area in patients with an acute myocardial infarct].

The effect of conventional and prolonged epidural analgesia (PEA) with morphine on the clinical course and the size of the focus of necrosis was studied and compared in 60 patients with acute myocardial infarction. In the basic group (n = 30), analgesia was carried out for 7 days with the aid of PEA. In the control group (n = 30), analgesia was performed by intravenous injection of morphine. In both the groups, the clinical course ant the size of the focus of myocardial necrosis were estimated (precordial cartography and detection of creatine phosphokinase made in series). PEA was established to bring about complete analgesia rapidly and safely, which in turn favours noticeable limitation of the focus of necrosis and amelioration of the clinical course of acute myocardial infarction. The effect produced by PEA was considerably higher in all the parameters as compared to that attained with conventional analgesia.

Analgesia, Epidural↗
PubMed1991

[Clinical course and necrotic area size in patients with myocardial infarct receiving combined treatment including antioxidants and membrane-protecting agents].

The efficacy of a combination of an antioxidant (alpha-tocopherol) and membrane-protective agents (nicotinamide, a lipase inhibitor and delagil, a phospholipase inhibitor) was evaluated in 25 patients with myocardial infarction in the acute period. The drugs were given no later than 8 hours of the onset of the disease within the first 10 days. Along with necrotic area limitation (by 20.2%) and neurotic myocardium was mass decrease by (34.9%), alpha-tocopherol in combination with nicotinamide and delagil was found to lower the frequency and severity of fatal complications, but fail to affect the incidence of relapses of postinfarction angina.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1991

[The clinical significance of leukocyte chemiluminescence in myocardial infarct].

A study was made of the luminol-dependent leukocyte chemiluminescence (LCL) of the whole blood in 45 patients with acute myocardial infarction (AMI). It has been shown that measurement of LCL during the first examination of the patient may play a significant part in the diagnosis of AMI. LCL monitoring is of independent importance for the control of resorption and reparative processes and for the diagnosis of the lingering course and threatened relapse of AMI. The authors provide evidence for the concept of the trigger inclusion of the leukocytic component into the chain of pathophysiological processes in AMI at hours 5-10 since its onset. Derangement of that mechanism may be one of the causes of the lingering and recurrent course of infarction. The treatment of AMI should be carried out with regard to the effect of therapeutic modalities on leukocyte function as well as to the phase of the pathophysiological process.

Adult↗
PubMed1989

[Effect of membrane protectors on the diastolic function of the heart in patients with acute myocardial infarction].

Apexcardiography was employed to make a noninvasive assessment of left ventricular diastolic function in 80 patients with extensive myocardial infarction. In half the patients, there were impairments in cardiac diastole as manifested by its altered phase structure and some changed parameters indirectly indicating a rise in left ventricular end diastolic pressure and a fall in myocardial relation rates and diastolic compliance. Prior 10-day administration of tocopherol and nicotinamide to 45 patients caused a decrease in the severity of diastolic abnormalities in those in whom the latter had been abnormal. The use of membrane protectors resulted in lower incidence of complications and improved outcome of the disease.

Adult↗
PubMed1986

[Status of cerebral hemodynamics during measured physical loading in healthy subjects and patients with cerebral atherosclerosis].

The authors analyzed the results of the rheoencephalographic examination of the cerebral hemodynamics under graded exercise (GE) in 42 normal subjects and 60 patients with cerebral atherosclerosis. All individuals were males aged 40-59 years. It was shown that an increase in the blood content of the brain in the process of GE in the patients with cerebral atherosclerosis was significantly lower than in the normal subjects. With a greater volume of the work done the difference became more pronounced. According to the nature of the response to GE the cerebral hemodynamics in the patients was divided into compensated, subcompensated and decompensated types.

Adaptation, Physiological↗