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Biomedical subjects

A A Fedorova

Publications and source records attributed to A A Fedorova.

6 recordsLinked to original sources
PubMed2004

[Detection of sodium monourate crystals in biopsies of gastric mucosa in patients with gout].

AIM: To examine gastric biopsies with polarization microscopy for detection of sodium monourate crystals (SMC). MATERIAL AND METHODS: The trial included 20 patients with gout diagnosis (mean age 55.7 years, mean duration of the disease 12.3 years) in whom esophagogastroduodenoscopy was made with biopsy of gastric mucosa from the antral part of the stomach and middle third of the gastric body. RESULTS: Crystals in the biopsy specimens were detected in 11 of 20 examinees. The crystals were characterized by strong double refraction, length 3-20 mcm, acicular or planiform shape, blue or yellow color depending on position in compensated polarized light. Quantitative distribution of the crystals within one biopsy specimen was uneven and varied from solitary crystals to clusters of 70-80 crystals in sight, up to formation of tophus-like structures. Clinical picture in detection of SMC was characterized by more frequent occurrence of cases with subcutaneous tophuses of various location combined with higher hyperuricemia. CONCLUSION: One of the essential lines in the research of gout concerns mechanisms of SMC formation in organs and tissues and microcrystalline gastroduodenal inflammation. Methods of correction of this inflammation are to be designed.

Adult↗
PubMedDate not supplied

[Effect of thyroxine in the G0 stage of the cell cycle on the yield of chromosome aberrations in rat hepatocytes and human lymphocytes after X-irradiation].

A study was made of the mechanism of a modifying action of thyroxin (T4) on the chromosome integrity after the application thereof in vivo and in vitro following a single whole-body exposure to X-radiation with a dose of 2.19 Gy. It is concluded that T4 influences the quantity of cells with chromosome aberrations stimulating the recovery of the chromosome integrity: the stimulation can be brought about at the G0 stage of the cell cycle as a result of the direct effect of the hormone on a cell.

Animals↗
PubMedDate not supplied

[Effect of thyroxine on the integrity of chromosomes].

Some features of the mechanism of thyroxin (T4) mutagenic effect in the culture of the human peripheral blood lymphocytes and the rat liver in vivo were studied. It was shown, that T4 mutagenic effect, discovered previously in the entire organism, can be stipulated by direct hormone-cell interaction. T4 mutagenic effect is associated with a change in DNA-dependent RNA polymerase activity and is realized during different phases of the cellular cycle. T4 modifying influence upon chromosome entirety is substantially limited by the age.

Animals↗
PubMedDate not supplied

[Cytogenetic changes in peripheral blood lymphocytes in people with impaired thyroid status].

Increased counts of cells with chromosome aberrations were revealed in peripheral blood lymphocytes of subjects with thyroid dysfunction: 5.5 +/- 0.6% in hypothyrosis, 9.0 +/- 1.8% in hyperthyroidism, and 2.5 +/- 0.1% in controls (20 donors). The aberrations are mainly presented by paired and solitary fragments, rarely by chromatid translocations; in two patients with hyperthyroidism dicentrics were detected. Distribution of aberration types varied. In hypothyrosis chromosome aberrations were two times more incident than chromatid ones. In hyperthyroidism chromosome and chromatid aberrations were approximately equally incident. These results may be used to explain the causes of unfavorable outcomes of pregnancy in patients with thyroid diseases.

Cell Cycle↗