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Biomedical subjects

A A Glukhov

Publications and source records attributed to A A Glukhov.

At least 19 recordsLinked to original sources
PubMed2006

[Minimally-invasive surgical treatment of perforated gastroduodenal ulcers].

The results of treatment of 249 patients aged 15 to 78 years with perforated gastroduodenal ulcers were analyzed. The study group consisted of 128 patients in whom video-laparoscopic procedure was used for suturing of ulcer, control group -- of 107 patients treated conventionally. Conversion of laparoscopic procedure to open surgery was in 14 cases. It is demonstrated that the intensity of pain syndrome, hospital stay and the number of postoperative complications in the study group were less that in the control group. Indications and contraindications for video-laparoscopic method in these patients were formulated.

Adolescent↗
PubMed2006

[Influence of the temperature regimen of sanitation of the abdominal cavity on the course of the syndrome of post-sanitation intoxication in patients with acute diffuse peritonitis].

The aim of the investigation was to work out and study effectiveness of the method of sanitation of the abdominal cavity in patients with acute diffuse peritonitis based on a combination of using the properties of hypo- and hyper-thermal solutions. The complex of experimental investigations has proved the safe clinical use of the proposed method to be possible, discovered main pathogenetic mechanisms of a positive influence of heterothermy when performing sanitation of the abdominal cavity against the background of acute peritonitis. The results of clinical approbation of the method in 86 patients have shown sufficiently high efficiency of using sanitation of the abdominal cavity in heterothermal regimen in a complex of measures for treatment of patients with acute peritonitis that allowed getting reliably lower degree of post-sanitation intoxication, less number of complications and lethal outcomes.

Abdominal Cavity↗
PubMed2004

[The method of parietal-cavitary sanitation of intestines in complex treatment of acute diffuse peritonitis].

Experimental investigations carried out in 154 white rats and 24 mongrel dogs have proved pathogenetical effectiveness and safety of using the method of parietal-cavitary sanitation of the intestine in treatment of acute experimental peritonitis. This method used in complex treatment in 28 patients with acute diffuse peritonitis allowed a 1.5-2 times quicker arrest of the syndrome of endogenous intoxication and liquidation of intestinal paresis. Infectious complications were 43% less frequent and the lethality indices were reduced by 9.5% as compared with the results obtained in the control group.

Acute Disease↗
PubMed2001

[Use of ozone therapy and hydro-pressure technologies in complex intensive therapy of surgical sepsis].

Results of treatment of 214 patients with severe sepsis and septic shock were analyzed. 125 patients treated with various methods of ozonotherapy and hydropressive sanation of infectious foci formed the study group. Control group consisted of 89 patients treated according to generally accepted principles. Comparative analysis of treatment efficacy was carried out with numerous laboratory and instrumental study methods. It is shown that ozonotherapy and hydropressive technologies reduced a lethality from 39.2% in the control group to 25.6% in the study group.

APACHE↗
PubMed2000

Modeling of acute experimental peritonitis.

A new method of modeling of acute diffuse peritonitis was designed and tested. The method reproduces clinical picture of severe purulent process in the abdominal cavity with clear phasic dynamics and uniform (in their nature and extent of dissemination) pathological reactions, which improves reliability of experimental data.

Acute Disease↗
PubMed2000

[Diagnosis and treatment of liver abscesses].

The authors experience in diagnosing and treating 67 patients with abscesses are summarized. The value of different methods of topic diagnosis is analyzed. New approaches to surgical treatment are presented, which involves the use of both open methods (dissection, sanitation and drainage of abscesses) and minimum invasive methods (abscess puncture under ultrasound and video laparoscopy guidance). The new method of assisted minimum invasive surgical treatment of large hepatic abscesses is described. To realize the principle of different approach to choosing treatment method and using new technologies permits improvement of treatment outcomes in these patients.

Adolescent↗
PubMed2000

[New trends in the treatment of liver abscesses].

The authors share their experiences with treatment of 85 patients with abscesses of the liver aged from 17 to 83 years. The size of abscesses was from 2.5 to 23 cm in diameter. For the topical diagnostics the following methods were used: ultrasound scanning, computed tomography, scintigraphy, diagnostic puncture biopsy of the liver, laparoscopy etc. Decision between the methods of operative treatment depended on the concrete clinical situation. Both open and minimally invasive methods were used. Hydropressive technologies and ozone therapy were used for better sanitation of the abscess cavity. A new method of the assisted minimally invasive intervention was developed especially for treatment of patients with large abscesses of the liver. The new technologies allowed to reduce the amount of postoperative complications and to make the time of staying at the hospital substantially shorter.

Adolescent↗
PubMed1999

[Treatment of peritonitis using ozone and hydropressive technology].

In the experiment on 144 mongrel dogs and 546 white rats the methods of ozone therapy and hydropressive treatment of the abdominal cavity have been worked out. These methods were used in the treatment of 94 patients aged from 13 to 89 years with severe forms of acute peritonitis. The control group consisted of 174 patients with peritonitis. A high antimicrobial effect was detected in the treatment of the abdominal cavity with microdisperse stream of the ozonated solution under pressure. After 1-2 procedures of the intestinal ozone dialysis the number of microbial bodies in the lumen of the small bowel in 65% of patients has decreased 2-3 times, the terms of elimination of the paresis has decreased 3-4 times, and more rapid dynamics of elimination of the endogenous intoxication syndrome was detected. The application of the developed programme of curative measures promote lowering of the lethality from 62.07% in the control group to 37.23%--in the test one.

Acute Disease↗
PubMed1998

[Wound treatment using the flow of an ozonized solution under high pressure].

New method for treatment of infected and festered, among them wounds with lingering healing was developed. The method was based on local application of fine-dispersion ozonized solution stream high pressure. This stream of ozonized fluid is generated under pressure of 350 ATM with the help of "Device for hydro-pressive treatment of wounds", ozonization of the solution is performed by the "OZh-2" apparatus developed by the authors. Application of the method of hydropressive ozonization provides fast cleansing of wound surface from pyonecrotic masses, promotes elimination of infection and thus substantially reduces the period of treatment of the patients.

Animals↗
PubMed1996

[The technic of liver resection].

The use of the method of jet dissection of tissue with the "jet scalpel" in resection of the liver for separation of the parenchyma allows to substantially decrease the intraoperative blood loss, to visualize the vessels and ducts and thus facilitates their ligation which prevents different complications. The device developed by the authors for reinfusion of blood is very helpful for preventing complications associated with the hemotransfusion therapy.

Adult↗
PubMed1996

[Jet dissection of tissues in liver surgery].

The results of applying jet dissection in resections of the liver in experiments and in the clinic are discussed. The method is based on washing off the hepatic tissues with a high-pressure jet of liquid to expose the intact vessels and ducts. To realize the method, "A device for separating tissues of parenchymatous organs" was developed, which worked according to the principle of an injector without a needle. The efficacy and the degree of trauma inflicted by the method were tested in experiments, after which it was applied in the clinic in 14 patients. The method made it possible to reduce essentially the volume of intraoperative blood loss, prevent the escape of bile in the postoperative period, reduce to the minimum hemotransfusion therapy, and shorten the stay of patients in the clinic. The results of jet dissection show the expedience of its use in surgical hepatology.

Animals↗
PubMed1994

["Jet scalpel" in the liver resection].

The use of the "jet scalpel" in liver resection allows the vascular-ductal structures to be adequately separated. This, in turn, prevents the risk of leaving hepatic areas devoid of blood supply or bile drainage, contributes to essential decrease of intraoperative blood loss, and decrease of the number of postoperative complications: bile seeping, biliary peritonitis, hepatic insufficiency, etc. The obtained results provide evidence that the use of the "jet scalpel" in surgical hepatology is advisable.

Adult↗