Biomedical subjects

A A Hemmati

Publications and source records attributed to A A Hemmati.

3 recordsLinked to original sources

PubMed2004

Effect of vitamins C and E on cognitive function in mouse.

The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250mg/kg per day) or Vitamin C (300mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E (250mg/kg per day) and Vitamin C (300mg/kg per day) for 60 days. The control group received only vehicle. The aged animal group (aged 15 months) were treated as the young group. Passive avoidance method was used for the assessment of cognitive function in both young and aged animals. The results indicated a significant improvement in the cognitive function of aged mice while there were no significant changes in young animals.

Aging↗

PubMed2002

The role of sodium cromolyn in treatment of paraquat-induced pulmonary fibrosis in rat.

Paraquat is a non-selective herbicide which is widely used in agriculture. It has potential of producing pulmonary fibrosis. In this study the therapeutic effect of different doses of sodium cromolyn on the development of paraquat-induced pulmonary fibrosis was investigated. In order to produce lung fibrosis, rats were given single oral dose of paraquat (40 mg kg(-1)). Two groups of animals were nebulised with 6 or 8 mg day(-1) cromolyn (divided into two doses per day) 5 days prior and 2 weeks after paraquat treatment. Control animals were given equivalent volume of normal saline and treated with cromolyn similar to the test groups. Rats were killed at the end of treatment course and lung tissues were tested histologically and biochemically. Histological examination of paraquat-treated animals showed marked infiltration of inflammatory cells in the alveolar spaces, septal thickening and fibrosis. Lesions were evident in many places of sections. Sodium cromolyn could markedly reduce such damages in lung tissue. Lung weight, hydroxyproline and collagen content of lung tissues were elevated significantly (P < 0.05) in paraquat group compared with control group. In cromolyn-treated groups such factors were near to control value and were significantly lower than paraquat group (P < 0.05). Results of this study indicate that sodium cromolyn can decrease the fibrogenic effect of paraquat on lung. Such effect may be due to the stabilising of mast cells and inhibition of inflammatory mediators by sodium cromolyn.

Animals↗

PubMed1999

Increased myofibroblast contractile sensitivity in paraquat pretreated rat lung tissue.

In numerous tissues, contractility to certain characteristic agents is associated with cells other than muscle, e.g. actin-containing so-called myofibroblasts. Such cells are present in pulmonary interstitium of several mammalian species but their contractility has only been demonstrated from the proliferation of myofibroblasts in fibrotic lung tissues. This study has been done to evaluate such responses in normal tissues in contrast with fibrotic lungs and it was necessary to take account also of smooth muscle reactivity. Distinctive agonists: mepyramine and sodium tungstate characterised myofibroblast mediated contractility, in contrast with acetylcholine and barium chloride as specific smooth muscle stimulants. Histology and immunohistochemistry were used to evaluate the pharmacological results more precisely.

Acetylcholine↗