Biomedical subjects
Publications and source records attributed to A A Ikizler.
Twenty-one new 1-methyl- and 1-ethyl-3,4-disubstituted-4,5-dihydro- 1H-1,2,4-triazol-5-ones were synthesized and characterised by elemental analysis, 1H-NMR and IR spectra. These new and 16 recently reported derivatives of 4,5-dihydro-1H-1,2,4-triazol-5-one ring were screened for their antibacterial activities.
Reactions of 3-amino-1,2,4-triazole with some dicarboxylic acid anhydrides and diketones were studied. The structural assignments of the compounds obtained from the reactions are based on elemental analyses and spectral data. The compounds were screened for their in vitro antibacterial activities.
Fourteen new potentially biologically active 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analysis, 1H NMR, IR and UV spectra. Three of these compounds were screened for their antitumor activities.
The reactions of 3-alkyl(aryl)-4-phenylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones with appropriate alkyl halides via sodio derivatives were studied and the corresponding 1-alkyl-3-alkyl(aryl)-4-phenylamino-4,5-dihydro-1H-1,2,4-traizol-5 -ones were synthesized. Next, the new compounds were tested for their in vitro antimicrobial activities.
Reactions of 3-substituted-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones [I] with some arenesulfonyl chlorides and aryl isocyanates were studied and the corresponding N-(3-substituted-4,5,-dihydro-1H-1,2,4-triazol-5-one-4-yl) arenesulfonamides [II-VI] and N-aryl-N-(3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl) ureas [V, VI] were obtained. The structural assignments of new 19 compounds are based on spectral data and elemental analysis. Furthermore, compounds II-VI were tested for their in vitro antimicrobial activities.
A series of 3-alkyl/aryl-4-arylidenamimo-4,5-dihydro-1H-1,2,4- triazol-5-ones was synthesized and characterized by elemental and spectral analysis. These compound were tested for in vitro antibacterial and antifungal activity in solid agar cultures against eight microorganisms. In these test, some of the new compounds were shown to be very potent in vitro antifungal activity against the used fungi.
The cyclization of ester thiosemicarbazones to two different heterocycles was studied for some new thiosemicarbazones, and only the formation of 1,2,4-triazol-5-thiols was attributed to the regioselectivity of the ring closure reaction, due to a steric hindrance of bulky groups. Next, some of the new compounds were tested for their in vitro antimicrobial and antitumor activities.
Eight new 3-alkyl(aryl)-4-arylidenamino-4,5-dihydro-1H-1,2,4-triazol-5 - ones were synthesized and characterised by elemental analysis. 1H NMR, IR and UV spectra. Seven new and 34 recently reported derivatives of 4,5-dihydro-1H-1,2,4 triazol-5-one ring were screened for their antitumor activities.
Nine new 1,3,4-trisubstituted-4,5-dihydro-1H-1,2,4-triazol-5-ones were synthesized and characterized by elemental analysis, 1H NMR, IR and UV spectra. These new and 30 recently reported 3,4-disubstituted- and 1,3,4-trisubstituted-4,5-dihydro-1H-1,3,4-triazol-5-ones were screened for antibacterial, antitumor and anti-HIV activities.