Biomedical subjects

A A Khodadoust

Publications and source records attributed to A A Khodadoust.

6 recordsLinked to original sources

PubMed1979

Transfer of bacterial infections by donor cornea in penetrating keratoplasty.

A 45-year-old man died of Hogdkin's disease complicated by peritonitis and possible septicemia. His corneas were used for transplant in a 26-year-old man with advanced keratoconus and a 42-year-old man with vascularized central leukoma of old herpetic keratitis. Both recipients developed a fulminating endophthalmitis with Pseudomonas aeruginosa. We believe that the donor corneas, although clinically normal, were heavily infected, with signs of inflammation possibly suppressed by the Hodgkin's disease.

Adult↗

PubMed1978

Microtropia.

Evaluation of 50 cases of microtropia that were collected within two years indicates the primary form of microtropia to be more common than the secondary form (48:2 cases). Various degrees of anisometropia were present in all cases of primary microtropia, suggesting that anisometropia is the cause rather than the consequence of microtropia.

Adolescent↗

PubMed1976

Physiological function of regenerating endothelium.

A defined area, 4 mm. diameter, cryothermal injury was created on a rabbit cornea. Corneal thickness was measured at four distances from the limbus to the center of the cornea during the swelling phase after endothelial damage, and during the recovery period. Rapid initial swelling was followed by a period of stable maximum thickness over 24 hours. More swelling occurred centrally than peripherally. Eight days after injury the peripheral cornea regained normal thickness, and the central portion was normal thickness after 10 to 12 days. Histological examination of corneal endothelium showed that early migration of cells into the denuded area occurred 6 hours after injury. By 2 days, most of the denuded area was covered by endothelial cells, although the cells were large and irregular. The number of normal cells increased, and of irregular cells decreased, over the next five days, until two weeks after freezing all cells had a normal appearance. The recovery of physiologic endothelial function lags behind the histologic recovery by about four to five days, indicating that recovery of the normal endothelial permeability is possibly related to the status of the cellular junctions rather than covering of the posterior surface by cells per se.

Animals↗

PubMed1976

Induction of corneal graft rejection by passive cell transfer.

An experimental model is presented demonstrating that penetrating corneal grafts in the rabbit may be rejected by passive transfer into the anterior chamber of specifically sensitized lymphoid cells. Destruction of histo-incompatible corneal endothelium is always marked by the formation of focal pock-like areas of damage in this system, rather than by the typical moving line of rejecting endothelium usually seen in spontaneous graft rejection. Where the transferred lymphoid cells are compatible with the tissues of the graft recipient, the picture is one of a severely affected graft on a field of uninvolved recipient corneal endothelium. Where the lymphoid cells are compatible with the graft and not with the tissues of the recipient, one sees a clear corneal graft surviving on a field of endothelial destruction on the recipient bed. The specificity of these reactions is illustrated in terms of the histocompatibility relationships between corneal donor, graft recipient, and the donor of the sensitized lymphoid cells.

Animals↗

PubMed1975

Local graft versus host reactions within the anterior chamber of the eye: the formation of corneal endothelial pocks.

Introduction into the rabbit's anterior chamber of lymphoid cells sensitized to the histocompatibility antigens of the recipient leads to the development of an intraocular graft versus host reaction. This takes the form of a more-or-less severe uveitis, and the production of small focal areas of endothelial cell destruction on the posterior surface of the cornea. In the milder responses, these present as discrete pocks on the endothelial layer, which heal rapidly. In the more severe reactions, the foci of endothelial destruction may be so numerous as to overlap, resulting in complete immunologic destruction of the entire endothelium. The dose-response relationships in this experimental system are discussed, as are its uses as a model for the study of the mechanism of endothelial damage during the course of specific corneal graft rejection.

Animals↗

PubMedDate not supplied

Spontaneous regression of retinoblastoma.

Clinicopathologic evidence of bilateral spontaneous regression of retinoblastoma in three brothers is presented. The buphthalmic right eye and phthisical left eye of one of these persons were examined histopathologically. The two brothers of this patient both had phthisical left eyes, and those eyes were examined histopathologically. Both of those brothers also had clinically detected chorioretinal scars in their right eyes from regressed retinoblastoma. Three of eight children of one of the two brothers had bilateral retinoblastoma, and two of seven children of the other brother had bilateral retinoblastoma. Reports in the literature of 50 previous cases of total spontaneous regression of retinoblastoma from 1911 to 1975 are reviewed.

Adolescent↗