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Biomedical subjects

A A Klimenkov

Publications and source records attributed to A A Klimenkov.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Correction of osmotic-volume status by parenteral feeding of patients with stomach cancer].

The paper discusses the interrelationship between osmo-volume parameters of homeostasis as well as the role of adequate parenteral nutrition in correction of surgery-associated disorders in gastric cancer patients. The study included 123 such cases. The baseline circulating blood volume and that of blood components was found decreased whereas blood serum osmotic index elevated. The above parameters correlated with each other and depended upon site and extent of tumor. Advanced cases with depleted reserves do not always respond to correcting therapy which may influence the outcome of surgery.

Aged↗
PubMed1990

[Sex steroid hormone receptors in cancer of the pancreas].

Samples of tumor tissue from 11 patients with pancreatic carcinoma were studied for cytoplasmic receptors of androgens and estrogens. Androgen receptors were identified in most tumors suggesting hormone-dependent nature of pancreatic cancer. Application of antiandrogens for pancreatic cancer treatment is discussed.

Adenocarcinoma↗
PubMed1990

[Strength of intercellular adhesion in gastric cancer].

Intercellular adhesion strength was measured after Koman in various parts of primary tumor and lymph node metastases of 43 patients with stage III-IV gastric cancer. Also, a fraction of low-adhesion (less than 0.20 mg) cells was assayed. Intercellular adhesion strength was 0.518 +/- 0.039 mg in primary tumor, 0.260 +/- 0.045 mg--invasion zone and 0.145 +/- 0.028 mg--in metastases. The share of low-adhesion cells was found to be 8.85 +/- 0.26, 65 +/- 4.32 and 87.16 +/- 2.5%, respectively.

Adenocarcinoma↗
PubMed1989

[Immediate outcome of gastrectomy with different variants of esophago-intestinal anastomosis].

Analysis of the results of 4 main types of esophago-intestinal anastomosis in 386 patients with gastric carcinoma showed G. V. Bondar's modification of end-loop anastomosis to be the simplest and most reliable method for introduction into wide surgical practice. In this type of anastomosis, insufficiency of the sutures occurred in 6% of 249 cases, the total fatality was 8.8%. The authors suggest 2 variants of gastroplasty operations which are marked by good functional outcomes but may be used in a limited number of patients because of relatively high death rates (12.1%).

Adenocarcinoma↗
PubMed1989

[Deficiency of the triiodothyronine pool in patients with stomach cancer].

Thyroid status was evaluated in 265 patients with gastric pathology. The degree of tissue triiodothyronine (T3) deficiency was assessed versus stage and histologic pattern of tumor. Also, it was measured before and after surgery. No correlation was found in gastric cancer patients between T3 concentration, degree of blood--T3 level decrease and tissue T3 deficiency, on the one hand, and stage and histologic pattern of tumor, radical surgery and postoperative treatment, on the other. Said T3 parameters differed significantly in cases of chronic gastritis, gastric ulcer and polyps.

Adenocarcinoma↗
PubMed1989

[Effects of splenectomy on long-term results of the surgical treatment of stomach cancer].

The long-term results of surgery including splenectomy as treatment for stomach cancer were evaluated in 321 such cases. Tumor- and surgical procedure--related splenectomies were considered separately. Splenectomy did not influence long-term results of treatment in the study group. The effect of splenectomy on cell-mediated immunity within six postoperative months is discussed.

Evaluation Studies as Topic↗
PubMed1987

[Cancer of the operated stomach as a problem of oncology today].

The study was based on the data obtained from a long-term follow-up of 2840 cases of various surgical pathology of the stomach, gastroscopic examination of 1112 surgically-treated patients, experiments on stomach carcinogenesis, clinical and experimental studies on lymph drainage pathways and analysis of the results of 296 radical operations for cancer of the gastric stump. The following aspects of research in cancer of operated stomach were suggested: (1) risk of cancer development in operated stomach; (2) factors contributing to tumorigenesis; (3) biologic peculiarities of growth of gastric stump tumors as well as lymph drainage pathways, and (4) organization of follow-up and development of methods for diagnosis and treatment of the said pathology. The results of the study outlined vistas in prevention of cancer of the gastric stump. Adequate methods of diagnosis and treatment of this grave pathology were developed which was followed by a decrease in postoperative lethality and in increase in 5-year survival rate--to 8.5 and 26.4%, respectively.

Age Factors↗
PubMed1987

Experimental carcinoma of the stomach in rats with chronic ulcers and following gastric surgery.

The data obtained did not prove the stimulating effect of experimental chronic ulcer on the induced carcinogenesis of the stomach in the rat. It is shown that some surgical procedures followed by a gastroduodenal reflux enhance the gastric carcinogenesis while the procedures without such a reflux do not reveal any modifying effect on stomach cancer. The results of this study together with data from literature may have some relevance to the treatment procedures of patients with gastric ulcers.

Animals↗
PubMed1986

[Disorder of thyroid function in patients with cancer of the gastrointestinal tract].

A quantitative assessment of T3 pool was performed in patients with malignant tumors of the esophagus, stomach, pancreatic head, rectum and colon as well as in patients with chronic gastritis, peptic ulcer and benign stomach tumors. A high T3 pool deficiency was noted in patients with malignant GIT tumors. It was assumed that such a deficiency was indicative of profound disorder of hormone supply of tissues which could be regarded as an endogenous factor of predisposition to the development of malignant neoplasms.

Digestive System Neoplasms↗
PubMed1985

[Monoclonal antibodies in the radioimmunological diagnosis of malignant tumors of the gastrointestinal tract and ovaries].

The report deals with the clinical significance of application of two procedures of radioimmunologic assay of levels of monoclonal CA-19-9 and CA-125 antigens in diagnosing gastrointestinal and ovarian malignancies. The CA-19-9 antigen test appeared to be ineffective at the early stages of development of malignant tumors of the stomach, rectum and colon. The level of the antigen showed an increase in 37% of cases of hepatic metastases only. However, the test may be instrumental in differentiating between inflammatory processes and malignancies in the pancreatohepatoduodenal area. CA-125 antigen serves as a discriminating marker for tumor involvement of the ovaries. However, its specificity in differentiating between benign and malignant tumors of this organ is under 63%.

Antibodies, Monoclonal↗