Biomedical subjects
Publications and source records attributed to A A Kolesnikova.
A case report of primary hyperparathyroidism with symptoms caused by hypercalcemia. Osteoporosis was detected only in thoracic spine. Test for parathormone provided a final diagnosis. The patient was treated surgically.
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The investigation used the mineral water (MW) Uralochka obtained from well 4638 located on the territory of the sanatorium Ural (the village of Khomutino, Chelyabinsk Region). Experimental findings suggest that the use of the Uralochka water for 14 days lowers experimental animals' sensitivity to stress. This is manifested by that MW use virtually completely eliminated the hematological manifestations of stress, poststress depression of a cell immunity response and prevented the reduction of cell counts in the abdominal cavity. The immunostimulating effect of the Uralochka MW on humoral immunity and the phagocytosis of peritoneal macrophages preserved with the combined influence of stress and MW.
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Drinking of mineral waters influences human immune system. Among the mechanisms of this action is a stress effect confirmed by increasing levels of glucocorticoids, catecholamines, by hyperglycemia, etc. Regular drinking of mineral water brings about adaptation. Development of long-term adaptation provokes defensive cross effects. It is suggested that an immunotropic action of mineral waters may be a manifestation of a defensive cross effect of the organism adaptation. Immunostimulation may also be related to suppression of T-suppressors activity and changes in cytokines levels.
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Neutrophilokine, a latex-activated neutrophilic secretory product, was tested for effects on the body's response to immobilization stress. Preadministration of neutrophilokine decreased the magnitude of post-stress changes: neutrophilic leukocytosis, lymphopenia, and stress-induced ulcerogenesis in the gastric mucosa. It is concluded that triple administration of neutrophilokine induces adaptation to immobilization stress.