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Biomedical subjects

A A Manina

Publications and source records attributed to A A Manina.

At least 19 recordsLinked to original sources
PubMed1978

[Subcellular reaction to cerebral hypoxia].

Compensatory-adaptive reaction of the brain to hypoxia depends on destructive and reparative processes developing in neuronal and glial elements. A drastic tension and reconstruction of the energy apparatus--mitochondria occurs, as well as reversible disturbances in informative connections between the nucleus and cytoplasm and between nerve fibers and synapses. As a result, structural-functional activity of organells decreases along with changes in metabolic processes. Destructive processes in oligodendroglia, at all stages of the experiment, are more pronounced than in neurons. Preliminary injection of hydroxybutyric acid to the animals preserves the cellular energy potential under hypoxia, that is evident from the lack of severe alterations in mitochondria and other organells. Mechanisms of the adaptive-compensatory reaction in cortical neurons under hypoxia are connected with tension and reconstruction of all organells of the brain cellular elements and with biochemical shifts of lactate dehydrogenase enzymes.

Adenosine Triphosphatases↗
PubMed1977

[Adaptive-compensatory reaction of the brain to irradiation].

In totally irradiated chick and rat embryos, young chicks and rats structural functional activity of the subcellular reparative processes in the brain cortex was studied. The animals were given an irradiation dose of 600 and 1,200 rad. In embryo-genesis and in early postnatal period, the adaptive compensatory response in shown after X-ray irradiation to be characterized by subcellular changes and organell hypertrophy of the neurons in the CNS accompanied by disturbances in metabolic and synthesis processes. Ultrastructural regeneration goes side by side with the destructive processes in them.

Adaptation, Physiological↗