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Biomedical subjects

A A Mikhaĭlov

Publications and source records attributed to A A Mikhaĭlov.

At least 19 recordsLinked to original sources
PubMed2004

[Daily blood pressure profiles and endothelial functions during long-term treatment of arterial hypertension with angiotensin-converting enzyme inhibitors].

Clinical practice has been recently applied new approaches to classifying patients with arterial hypertension (AH), which are based on the determination of the summary risk suggesting the prognosis of the disease. This approach is quite efficient due to the fact that it takes into account a combination of the comparable clinical symptoms of AH, which characterize its course. The paper presents data on the values of blood pressure (BP) in AH and on daily BP profiles (DBPP) in 494 patients with different categories of a risk and on their endothelial function. It also gives the results of achievement of target BP levels in patients with AH having different categories of a risk during long-term (36-month) treatment with enapril and perindopril, as well as data on its impact on endothelial vasomotor function. The findings suggest that the higher the risk is, the more severe the hypertensive syndrome is; that the redistribution of DBPP occurs towards prognostically poor types and endothelial dysfunction (EDF) progresses. Treatment with angiotensin-converting enzyme (ACE) inhibitors results not only to the achievement of target BP levels and to the normalization of DBPP, but also to the amelioration of EDF. Moreover, the co-administration of ACE inhibitors and isosorbide-5-mononitrates causes additional antiischemic effects.

Adolescent↗
PubMed1991

[Intensive therapy of DIC-syndrome in patients with acute renal insufficiency caused by long-term crush syndrome].

Impairment of parenchymatous organs, primarily kidneys, responsible for their dysfunction in crush syndrome results in many respects from disseminated intravascular coagulation (DIC). It is also associated with hemorrhagic complications. It is demonstrated that treatment modalities aimed at arrest of DIC syndrome (plasmapheresis, heparin, dysaggregation drugs, transfusions of large amounts of fresh frozen plasma) stopped bleeding and septic shock in 12 patients with crush syndrome following the earthquake in Armenia (1988).

Acute Kidney Injury↗
PubMed1990

[Effects of mildronate (quaterin) on hemodynamics in spontaneous and artificial heart rhythm in patients with ischemic heart disease].

Central hemodynamic parameters under the effect of mildronate were examined in 62 patients suffering from coronary heart disease, 35 of these with acute myocardial infarction complicated by acute left-ventricular insufficiency and 20 with atherosclerotic cardiosclerosis with chronic cardiac insufficiency. The drug effect was assessed in two groups of patients after a single intravenous injection of 0.5-3 g. In group 1 (n = 53) mildronate effect on central hemodynamic parameters was assessed in spontaneous cardiac rhythm. Variously directed statistically unreliable hemodynamic shifts were revealed, related to heart rhythm changes. In group 2 (n = 9) the drug effect on heart rhythm was eliminated with the use of two-chamber electrocardiostimulation, and various hemodynamic regimens with hypo-, eu-, and hyperkinetic circulation types were artificially created by changing the A-V interval. Mildronate had no effect on the hemodynamics during two-chamber electrocardiostimulation.

Adult↗
PubMed1986

[Activity of the nucleolar organizers of the cells in epithelial tumors of the human large intestine].

Normal, adenoma and cancer cell nucleoli have been studied by silver impregnation in 13 cancer patients, 48 patients with adenoma (14-tubular, 35-tubulovillous and villous) and 15 controls. It has been shown that the content of silver granules per cell was significantly higher (34.0 +/- 9.7) in cancer cells than in the control (12.3 +/- 3.1). Adenoma cells were heterogeneous. Most villous adenomas, like adenocarcinomas, had high content of Ag granules per cell. The importance of these findings for theoretical and clinical oncology is discussed.

Adenocarcinoma↗
PubMed1986

[Pharmacokinetics of digoxin in middle-aged and elderly patients in the subacute period of myocardial infarction].

Elderly and old patients with subacute myocardial infarction showed elevated gastrointestinal digoxin absorption rates and a tendency to increased bioavailability of the drug, as compared to similar parameters in infarction-free patients of the same age, so that blood digoxin peaks were higher in the former. The demonstrated absorption changes may be related to limited physical activity of the myocardial infarction patients examined. Digoxin pharmacokinetic patterns are analysed with reference to baseline myocardial contractility.

Administration, Oral↗
PubMed1986

[Pharmacodynamic and pharmacokinetic approaches to optimization of the use of digoxin in the subacute period of myocardial infarction in late middle-age and elderly patients].

The efficiency of digoxin in elderly and old patients with subacute myocardial infarction is dependent on the original disorders of left-ventricular systolic phase structure. Changes in systolic phase structural parameters in the presence of supporting digoxin therapy show correspondence to changes of these parameters in response to a single digoxin dose. Digoxin's positive inotropic effect was similar in patients with the sinus rhythm and those with atrial fibrillation. The positive inotropic action of digoxin is not associated with a negative chronotropic effect in patients with sinus rhythm and normal heart rate.

Aged↗
PubMed1985

[Clinico-morphologic comparisons in villous and adenovillous tumors of the colon].

The data on 330 cases of villous and tubular-villous adenoma of the colon were analysed. The results of histological examination of resected material were compared with the evidence provided by clinico-endoscopic examination as well as preoperative bioptic findings. Since none of the above procedures proved to be of diagnostic value in detective invasive growth of villous tumor, it makes the case for total biopsy as the only reliable diagnostic procedure.

Colonic Neoplasms↗