The effect of human chorionic gonadotropin hormone on functional recovery of the spinal cord in the rat after acute spinal cord sectioning.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to A A Patil.
Explore the source record for details and available documents.
A new stereotactic head clamp is described. The clamp is applied in the plane of the computed tomographic scan, and enables one to probe the target in te plane of the scan by obtaining measurements directly from the scanner. No modification of the scanner is required, and the clamp can be used within the scanner.
A case of arteriovenous malformation (AVM) of the cerebellum and brainstem at the cerebellopontine angle is reported. Though a postoperative angiogram after the first operation indicated complete excision of the lesion, the patient returned with subarachnoid haemorrhage, and an angiogram indicated reappearance of the lesion. Total excision was carried out at the second operation.
Explore the source record for details and available documents.
A new and simple computed tomography (CT)-oriented stereotactic system that uses the basic principle of working in the CT plane of the target is described. The system consists of a movably mounted frame carrying an adjustable probe holder capable of sliding along the length of the frame and being inclined to any desired angle, together with an independently mounted head fixed system. The movably mounted frame and the sliding probe holder are adjusted in the CT plane of the target. The angle and the distance to which the probe holder should be adjusted for accurate probing can be obtained from a single scan image. The system can be used in any total body scanner with standard features. No special computer programming is necessary, and no calculations are needed. The operation of the system is described wit illustrative cases.
A case presenting with focal seizure, and with CT scan and histological evidence of arteriovenous malformation, but with a normal angiogram, is described. Relevant literature is reviewed, a caution is added in assuming total excision of an AVM based on postoperative angiography findings.
The author reports the surgical removal of an extensive arteriovenous malformation involving the cerebellum and the brain stem. Postoperative recovery of the patient was good. Relevant literature has been reviewed, and the operative approach is discussed.
Electromagnetic-field focusing (EFF) is a method of converging induced eddy current onto a pointed tip of a tuned length return circuit in the near field of a resonator, which results in the production of high temperature. Previously reported applications of this method include various devices for local hyperthermia and a precision surgical device. The latter is currently being used in human clinical trials under two investigational device exemptions from the Food and Drug Administration. In the present work, the thermal profile produced in a uniform, tissue-simulating phantom by the hand-held probe of the surgical EFF system is compared with those produced by mono- and bipolar electrocauteries and by a contact Nd:YAG laser. At the equivalent power setting and 2-cm insertion depth, the EFF probe was shown to have a tighter thermal profile than the monopolar electrocautery or the contact Nd:YAG laser. This finding is consistent with earlier histologic evidence that brain cortical tissue cut by the surgical EFF probe had minimal thermal damage in the tissue surrounding the incision.
The EFF probe has the capability of sharply focusing the eddy currents produced in tissue secondary to the electromagnetic field it generates. This sharp convergence of eddy current produces intense heat at the point of contact of the probe to the tissue, which can vaporize tissue. The probe diameter can be as small as required which makes it easy to be navigated into disc space for disc vaporization. Four discs were vaporized in three pigs by inserting the probe into the disc and vaporizing it. The vertebral columns were removed and transverse sections through the disc were made. Excellent disc vaporization was observed with vaporization of 70-80% of the nucleus. As the probe can be of flexible material it could be turned in different directions to vaporize necessary disc material.
The effect of human chorionic gonadotropin (HCG) hormone on restoration of physiological continuity of the spinal cord in rats was studied. After complete transection of the spinal cord at the midthoracic level eleven of these 21 rats in the study received HCG for six weeks. The other ten served as controls. At the end of six weeks amplitude of the cortically evoked motor At the end of six weeks amplitude of the cortically evoked motor action potential (CEMAP) was measured. The amplitude of the motor action potentials was significantly greater (P less than 0.02) in HCG treated rats. The study thus shows that HCG might help in the restoration of spinal cord function.