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Biomedical subjects

A A Pokrovskiĭ

Publications and source records attributed to A A Pokrovskiĭ.

At least 19 recordsLinked to original sources
PubMed1977

[Body resistance to the exposure to sound against a background of unbalanced nutrition].

Subject to study was the influence exercised by the excess of a number of vitamins in the diet (thiamine, ascorbic acid, cyanocolbalamine, riboflavin and pyridoxine) on the spastic susceptibility of the organism under the effect of a strong sonic stimulant. Pyridoxine exerted a noticeable protective influence on audiogenic convulsions. Its protective effect increased with its combined application with riboflavin, succinate and glutamic acid. The possible mechanism of action of the studied vitamins and of their combinations with glutamic acid and succinate on the spastic susceptibility of the organism is discussed in the paper.

Acoustic Stimulation↗
PubMed1976

[Membranotoxins].

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Aflatoxins↗
PubMed1976

[A method of studying hydrochloric acid secretion in isolated gastric mucous membrane using a two-channel pH-meter].

A new method of hydrochloric acid secretion recording on two symmetrical parts of the same isolated gastric mucosa is described. A two-channel system which had a number of important advantages over a single-channel system was used. The advantage of this method lay in a possibility of a more exact differentiation of the influence of different substances on the rate of H+ secretion and in a considerable decrease in the number of animals required for the experiments. The apparatus scheme for a two-channel recording of H+ secretion, and design of the four-chamber cuvette are described.

Gastric Acidity Determination↗
PubMed1975

[The effect of sporofusarin on the cell membranes of isolated perfused liver].

A study was made of the effect of sporofusarin (mycotoxin produced by Fusarium Sporotrichiella v. Sporotrichoides) on the functional activity and permeability of cell membranes of the isolated perfused rat liver. Sporofusarin (in the end concentration of 5.9 . 10(-5) M) produced a marked depressive effect on the rate of bile, formation, urea synthesis and oxygen consumption, and also caused an early and marked disturbance of permeability of the lysosomal and plasma membranes of hepatocytes (an increase in the activity of the enzymes--beta-acetylglucosaminidase, beta-glucuronidase, arylsulfatases A and B, beta-galactosidase in the supernatant fluid of liver homogenate and in the perfusata). It is supposed that depression of the functional activity of the liver under the effect of sporofusarin resulted from damage of the membrane structures of the cell, and, primarily, of lysosomes.

Acetylglucosaminidase↗
PubMed1975

[Morphologic and biochemical heterogeneity of lysosomes].

By means of isopycnic centrifugation in the continuous density gradient of sucrose two subfractions of lysosomes were isolated from rat liver homogenates: a "light" one (with the floating density p=1.13) and a "heavy" one (p=1.24). Electron microscopic, enzymatic and electron microscope enzymatic analysis of the isolated subfractions showed that the "light" subfraction consisted mainly of newly-formed primary lysosomes, while the "heavy" one was presented by secondary lysosomes. Parallel biochemical investigations demonstrated a considerable enzymatic heterogeneity of the two lysosomal subfractions: the "light" subfraction was characterized by a high specific activity of acid DNase, acid RNase and beta-galactosidase, and by almost total absence of beta-glucosidase activity, while the "heavy" one was characterized by a high specific activity of beta-glucosidase, beta-glucuronidase and beta-N-acetylglucosaminidase. Possible causes of enzyme heterogeneity of rat liver lysosomes are discussed.

Acetylglucosaminidase↗
PubMed1975

[Morphologic, biochemical and functional properties of the mitochondria of the rabbit gastric mucosa].

Purified fractions of the rabbit gastric mucosa and liver mitochondria were isolated. Electrone microscopy and functional studies of mitochondria showed the most intact mitochondria of gastric mucosa to be localized in gradient fractions of p=1.16-1.18, and those of the liver in fractions with p=1.19-1.20. The gastric mitochondria differed from the liver mitochondria by specific localization in oxyntic cells, abundance of crists, small matrix volume, presence of high respiratory control at lesser values of pH, high respiratory activity, great amount of cytochromes of electron transport chain in inner mitochondria membrane, two-fold excess of cytochroma a in relation to b and c, absence of b5 and by presence of great amount of phosphathydilaethanolamine and unsaturated fatty acids.

Acid Phosphatase↗