Biomedical subjects
A A Ramelet
Publications and source records attributed to A A Ramelet.
Müller phlebectomy. A new phlebectomy hook.
The phlebectomy hooks allow aesthetic and efficient removal of all types of varicose veins by means of small incisions (1-3 mm) according to the technique invented by Dr. Robert Müller. Brief review of Müller's phlebectomy and discussion of the advantages of this new device.
[Clinical and cutaneous aspects of chronic venous insufficiency].
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[Ambulatory treatment of chronic venous insufficiency].
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[Ambulatory phlebectomy by the Muller method: technique, advantages, and disadvantages].
Phlebectomy according to Muller is a simple and efficient method. A very narrow incision (1 to 2 mm) makes it possible to grasp the varicose vein with a small hook and to extract it. Indications are numerous: varices of the trunk (without insufficiency of the great saphenous vein junction), perforating varices, reticular varices, nutrient veins of telangiectasias or of leg ulcers, unsightly veins (in the eyelids, arms, etc.). There are numerous advantages of phlebectomy according to Muller. In terms of ambulatory patients, it is a simple technique free of risks (especially thromboembolic ones) for surgical treatment of all types of varices. This technique is particularly economical (simple infrastructure, little loss of patient work time). Elective extirpation of varicose veins allows the healthy venous trunks to be conserved (reconstructive surgery) and scars are practically invisible. In terms of hospital practice, this technique has been adopted by numerous surgeons as a complement to resection of the sapheno-femoral junction and stripping, thus permitting reduction of scar size and extirpation of the narrowest varices. The drawbacks are minimal: the usual complications of any surgical technique and too easy accessibility to the poorly trained practitioner.
[The skin of the aged].
This is a review of physiological changes and photo-aging of the senescent skin and of their clinical aspects. It also contains a discussion of the origins pruritus in elderly people.
Direct mycological examination in dermatology: a comparison of different methods.
Direct examination for fungi in skin and nail scrapings can be done by light microscopy with or without staining, or by fluorescence microscopy using specific fluorochromes for the fungal cell wall constituents. The principal techniques described in the literature and two new methods (Congo red and Na2S-Blankophor P flüssig) were compared for their efficiency and rapidity.
[The treatment of varicose ulcers].
The cause of venous ulcer (deep veins and perforans veins valvular damages, muscular and articular pump deficiency) can merely be corrected by compression therapy and, in some cases, surgery. Accompanying diseases have to be treated. Although the efficiency of general and local treatment is limited, it is essential to control it correctly and avoid its side-effects.
Lack of endocrine systemic side effects after topical application of spironolactone in man.
In six healthy male volunteers, the percutaneous absorption of spironolactone was compared with placebo in a double-blind crossover study. The subjects were randomly given either a cream containing 5% spironolactone or placebo to be applied in a randomized sequential way to a well defined skin area equivalent to 55% of body area. During the 72 h following the application of the ointment, blood levels of canrenone, the major metabolite of spironolactone, have been determined. In order to estimate the systemic antiandrogenic effect of spironolactone, plasma levels of 17-alpha-Hydroxy progesterone (17 alpha-OH-P), Testosterone (pT) and non-conjugated 3 alpha-Androstanediol (3 alpha-diol, metabolite of the active androgen 5 alpha-Dihydrotestosterone or DHT) as well as salivary Testosterone (sT) which relate to the free and active plasma testosterone fraction have also been measured. Urinary levels of canrenone have been determined 48 hours after cream application. No changes in any levels of these hormones have been detected and plasma canrenone levels were undetectable during the 72 hours of topical treatment. Topically administered, spironolactone appears to have only a local skin impregnation.
[Rosacea: histopathologic study of 75 cases].
Few histological studies have been devoted to rosacea, a common but ill-defined disease. We have examined histological sections obtained from 75 patients (41 men aged from 23 to 72 years and 34 women aged from 32 to 68 years), thereby confirming the diagnosis of rosacea. On average, 4 sections from each patient were examined. Blocks from cases with granuloma were serially sectioned in search of remains of hair follicles, degenerated collagen fibres and Demodex folliculorum. Elastotic degeneration, vasodilatation and the number of hair follicles were evaluated; the nature and disposition of inflammatory infiltrates were determined, and the presence of D. folliculorum was looked for. Elastotic degeneration, varying degrees of vasodilatation and inflammatory infiltrates were found in all patients. The infiltrates were predominantly lympho-histiocytic in 62 cases, neutrophilic around skin appendages in 6 cases, tuberculoid unrelated to appendages in 4 cases and tuberculoid surrounding follicle-related necrosis in 3 cases. The number and appearance of hair follicles seemed to be those normally observed in the regions where our specimens were taken. On the basis of histological, immunological and therapeutic arguments, it has been postulated that D. folliculorum was involved in the pathogenesis of rosacea, notably in its granulomatous form. In particular, several cases of granuloma containing the acarid in its core have been reported. However, the significance of such findings remains uncertain. D. folliculorum might induce the formation of a granuloma, but it is also possible that granulomas are consecutive to the destruction and resorption of hair follicles, the mite being "digested" more slowly than the epithelial structures.(ABSTRACT TRUNCATED AT 250 WORDS)
One daily application of oxiconazole cream is sufficient for treating dermatomycoses.
A single daily application of oxiconazole cream was shown, in a double-blind, randomized, multicentric study, to be effective in treating various dermatomycoses as well as erythrasma. Tolerance was excellent and side effects were negligible.
Association of acrodermatitis chronica atrophicans and morphea.
A patient developed successively acrodermatitis chronica atrophicans (ACA) and localized scleroderma. ACA was demonstrated to be a tick-borne disease, whereas morphea is only suspected to be one. As morphea appeared after successful treatment of ACA, it suggests that localized scleroderma is not directly an infectious disease but might be rather the consequence of spirochetal infection.
Lack of effect of a spironolactone-containing cream on hair growth in hirsute women.
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[Immunofluorescence in dermatology].
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Rosacea: disease or reaction pattern?
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Minoxidil induces selective regrowth of androgenetic dependent hair.
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[Eccrine porocarcinoma. Presentation of 4 cases].
Eccrine porocarcinoma is a rare malignant skin tumor arising from the epidermal sweat duct unit (acrosyringium). The report of 4 cases illustrates the clinical and histological characteristics. The prognosis of this carcinoma remains difficult to assess because of the lack of a catamnestic study.
Failure of lysine in frequently recurrent herpes simplex infection.
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