Biomedical subjects
Publications and source records attributed to A A Robinson.
It has been reported that the stimulation of travelling in a motor vehicle triggers abnormal hormonal and adrenal excretion and also abnormal changes in the body's fuel system. Figures presented in this paper suggest that motor vehicle travel may be important in breast cancer deaths.
Findings based on a number of statistical studies indicate that road accident deaths (RAD) are a significant measure of vehicular usage. All forms of cancer have highly significant relationships with RAD for males and females, indicating a possible common cause. Circulatory complaints also show the same highly significant correlation. The relationship between cerebrovascular disease (CV) and total cancer (TC), is discussed for Australia, the USA and France, for both males and females, by age group. Indications are that fibrin (as a result of the reduction in coagulation time while driving) might be a factor involved in causation of all cancers.
Driving tests carried out (1) indicate hormonal changes are taking place in the blood while driving or travelling in a motor vehicle. Figures presented in this paper show that female hormonal changes, of an abnormal nature, taking place in the pregnant female while driving or travelling in a motor vehicle, are having a deleterious effect causing abnormal development of the unborn child, male infants being affected at a much higher rate than female infants.
Results of analysis of statistical data gathered and studied over a period from 1968-1989 have led to findings indicating that all cancers have a common cause. A relationship has been studied between the number of deaths due to all types of cancer and road accident deaths in time, by age, sex, and country. Road accident deaths in this paper are considered to be a measure of miles travelled for both males and females.
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Data is presented that indicates that Ischaemic heart disease and Cerebrovascular disease are the result of the deleterious effect caused by driving or travelling in a motor vehicle. Ischaemic heart disease (IHD) Cerebrovascular disease (C/V) also referred to as (stroke) Road accident deaths (RAD).
It is suggested that according to experimental evidence, the stimulation of automatic body functions by travelling in motor vehicles leads to the development of lung cancer. The data available for Australia during the period 1940 to 1984 also shows that the difference between male and female lung cancer rates may be explained by exposure to travel.
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Mathematical data are presented supporting a relationship between road accident deaths (RAD), male and female, and ischaemic heart disease (IHD) deaths, male and female, in Australia. It is suggested that RAD on a national scale are a function of vehicle usage, for both males and females, and in turn, vehicle usage creates stress on bodily function resulting in IHD.
The haemodynamic indices of three patients, who developed abdominal tamponade as a result of intra-abdominal bleeding following liver transplantation, were measured on four occasions as the increased intra-abdominal pressure was released. Hypotension followed the release of the tamponade in all patients and was the result of a decrease in systemic vascular resistance. This was treated with vasoconstrictors; the response to various agents was monitored. Treatment of hypotension following release of abdominal tamponade by volume replacement alone may be inappropriate and may lead to over-transfusion; adrenaline may be the treatment of choice. Intensive haemodynamic monitoring is advisable.
Percutaneous needle biopsies were performed on 683 patients with solitary pulmonary nodules during 1976-84. A cytological diagnosis of malignancy was made from the first biopsy in 473 patients (69%). A second biopsy was performed in 43 patients, a diagnosis of malignancy being made in a further 16 cases (37%). Histological material was available for comparison with cytological findings in 203 patients. Cytological examination was reliable in the diagnosis of malignancy with a high yield (75%) and low false positive rate (1.5%). Specific benign lesions were correctly diagnosed in 10 patients (1.5%). There was a false negative rate for the diagnosis of malignancy of 18% for the patients with a subsequent histological diagnosis. This compares with a false negative rate of 9% overall; the true rate probably lies between these figures. These results imply that a cytology report indicating no evidence of malignancy, but not diagnostic of a specific benign condition, does not reliably exclude a malignant lesion. In this series cytological typing was not accurate at predicting the cell type determined by histological examination (61% agreement) and was not able to discriminate between small cell and non-small cell lung cancer.
This study draws attention to difficulties in the diagnosis and the understanding of the mechanism of action of mushroom compost worker's lung. Descriptions are given of 4 workers in one factory who developed acute respiratory failure within a 6-month period; 13 others who were unaffected were also studied. Serological investigation appears to be largely unhelpful, and the evidence against the condition being included amongst the extrinsic allergic alveolitides is discussed. A detailed clinical and occupational history is essential for diagnosis.
52 severely ill asthmatic patients requiring acute admission to hospital entered a double-blind placebo-controlled trial to determine whether intravenous hydrocortisone given in addition to high-dose oral prednisolone and standard bronchodilator therapy accelerated recovery. Patients who had been given parenteral steroids before admission, by comparison with those who had not received such treatment, had been deteriorating for a shorter period before admission, had received more injected or nebulised bronchodilator therapy, and had higher admission peak flows. As judged by peak flow measurements 24 h after admission, parenteral steroids had no effect on the outcome, irrespective of whether they were given before or after (ie, intravenous hydrocortisone) admission. There is no evidence for the continued use of intravenous hydrocortisone in addition to oral prednisolone and bronchodilator therapy in patients admitted to hospital with severe asthma without ventilatory failure.
Lung cancer is shown to be predicted from petrol consumption figures for a period of 42 years. The mean time for the disease to develop is discussed and the difference in the mortality rate for male and females is explained.
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It is shown that significant changes in the blood takes place when driving in a motor vehicle. The risk of death in various occupations due to diseases related to body malfunction is calculated and this demonstrates the high risk of workers in transport. A further test of data, the correlation of deaths from all causes, both male and female, with male and female road accident deaths respectively is presented and supports the above-mentioned findings. These correlations also demonstrate surprisingly strong relationships with many diseases and motor vehicle travel. These diseases are normally considered to have no known cause.
Tests to examine changes in glucose, cholesterol, triglycerides and free fatty acids in the blood, in the first quarter hour of driving have been carried out. Statistically significant positive changes of glucose and cholesterol were found. High negative percentage change in triglycerides, though not statistically significant, were recorded. As travel without the expenditure of energy is abnormal to the body, these changes in the blood cause deleterious effects on the metabolic system.