[Transfer of 3H-aldosterone from the cytosol receptors of the kidney tubule cells of rats to the nuclear ones in reflex and denervation dystrophies of this organ].
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Aldosterone↗
Biomedical subjects
A A Rodionov
Publications and source records attributed to A A Rodionov.
[Molecular mechanisms of the effect of neurogenic dystrophy of the kidneys in the rat on the sensitivity of the organ to aldosterone].
The effect of reflex and denervated dystrophy of the rat kidneys on the interaction of aldosterone-3H with specific cytoplasmic receptors and nuclei of this organ was investigated in vitro and in vivo experiments. It was found that reflex dystrophy decreases the intensity of hormone binding with cytoplasmic receptors by 36% and aldosterone-3H accumulation in the renal nuclei by 51%. The influence of denervated dystrophy of the organ specific hormone accumulation in the same subcellular fractions was not observed. The more accurate data on the effect of renal reflex dystrophy on aldosterone-3H-receptor interaction were obtained in vivo experiments comparatively to those in vitro.
Aldosterone↗
[Mechanism of aldosterone reception in mammalian kidneys].
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Aldosterone↗
[Specific aldosterone reception by the cytoplasm of the kidney tubule cells in rats with neurogenic dystrophy].
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Aldosterone↗
[3H-aldosterone binding by rat kidney cytosol in reflex and denervation dystrophy of this organ].
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Aldosterone↗
[Do nitrite ions participate in regulating systems of intra- and intercellular signalling?].
Effect of nitrite ions on content of proteins (hemoglobin, albumin and others), peptides (AKTH and endothelin-1, 2) of total alpha-aminonitrogen and cGMP was studied in rat blood. The data obtained suggest that NO2- may be involved in regulation of these physiologically active substances because NO2- are the deposited form of nitric oxide which may regulate the inter- and intracellular signal systems.
Animals↗
[The effect of the drug-induced activation and deprivation of the sympathetic nervous system on aldosterone receptor binding by the kidney with disturbed neurotrophic support].
The results of studies are presented on the determination of aldosterone accumulation by mineralocorticoid receptors on cytoplasm and nuclei of normal rat renal tubules as well as in disturbed neurotrophic supply of the kidney including that against the background of activation and deprivation of the sympathetic nervous system function. It was shown that a pharmacological stimulation of sympathetic nervous system potentiated functional disturbances of the renal mineralocorticoid receptor apparatus in reflex dystrophy of the kidney. A simultaneous pharmacological blockade both of neural and of humoral transmission of pathological stimuli from damaged sciatic nerve to the kidney prevented the development of these disturbances. A belief is stated that there is a possibility of using adrenoceptor blockers as means to prevent or inhibit the development of dystrophic alterations in the organism which appear under the lesion of one or other part of the nervous system.
Aldosterone↗