Biomedical subjects
Publications and source records attributed to A A Runovich.
The composition of the protein-peptide complex of cryopreserved human fetal tissues and juvenile tissues of newborn rabbits was studied by spectrophotometric and chromatographic methods (liquid, thin layer, and reaction paper chromatography).
The study included 30 IHD patients with primary hypercholesterolemia (22 males and 8 females). 18 and 12 patients have received a single daily dose of fluvastatin 20 and 40 mg, respectively, in the evening for 12 weeks. The drug effect was assessed by changes in the clinical status, lipid spectrum, transport-metabolic and absorption-secretory functions of the liver. IHD patients with hypercholesterolemia were found to have dysfunction of the hepatobiliary system. Fluvastatin treatment reduced the level of total cholesterol (Ch), LDLP Ch, triglycerides. HDLP Ch levels remained unchanged. Atherogenic lipoproteins aggregation diminished. Positive changes occurred in hepatic metabolism: bilirubin concentrations lowered, serum albumin went up, absorption-secretory function of hepatocytes normalized, hepatic mono-oxidase system activated. Fluvastatin-related hepatic damage was not reported in the course of 12-month follow-up.
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The authors conducted contrast study of the position of the cavacatheter in all patients treated in the period of 12 months in the thoracic surgery department and the anesthesiology-resuscitation department who required long-term intensive therapy. In 61 of these patients the catheter was introduced through the left subclavian vein. An accessory left superior vena cava (ALSVC) which drained through the coronary sinus into the right atrium was found in 3 patients (4.9%). Study of the anatomical features of this venous anomaly led to the conclusion that prolonged infusion therapy through an ALSVC is undesirable.
Follow-up observations during the period from 1 to 5 years were performed in 12 of 18 patients subjected to bilateral resections of lungs for chronic pulmonary suppurations. Different forms of lung hypertension were revealed in 9 out of the 12 patients. The function of external ventilation was found to be disturbed in a considerable degree.
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The authors describe the treatment of 23 patients with a severe form of infectional-allergic bronchial asthma by continuous peridural blockade. Positive results of the peridural injection of the anesthetic drug was observed in cases with localization of the autosensibilization in the broncho-pulmonary system. The peridural blockade was not found to be effective for the treatment of bronchial asthma against the background of chronic diseases of otorhinolaryngologic organs. The effect of peridural blockade was most pronounced and stable in restricted forms of chronic bronchitis or pneumonia without exacerbation.
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To reveal inoperable cases in 236 patients with pulmonary cancer the following special methods of study were employed: bronchoscopy--in 116 patients, pneumomediastinotomography--in 50, azygo-hemiazygography--in 127, mediastinography with the use of water-soluble contrast substances--in 6, prescalene biopsy--in 15 and mediastinoscopy--in 43. An analysis of the results obtained has shown that each of these specific methods of investigation has definite diagnostic limits, not being comprehensive for judging the status of the mediastinum, as a whole. Therefore, their complex utilization in a succession that would take into account the maximum information of each diagnostic procedure is being suggested.
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We studied effects of neonatal hepatocytes transplantation (NHT) on lipid metabolism and hemostasis in experimental hypercholesterolemia. A positive NHT influence on lipid metabolism, lipid peroxidation and hemostasis was established. The experimental data evidence for preferential influence of intrahepatic NHT on lipid metabolism and hemostasis compared to intravenous NHT.
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