PRESENT STATUS OF PLATELET AGGREGATION.
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Biomedical subjects
Publications and source records attributed to A A SHARP.
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Nine patients are described, four men and five women, aged between 14 and 62 years, who presented with symptoms of severe anaemia. Deficiencies of iron and folic acid were subsequently demonstrated in each case. Although malabsorption was not initially suspected, further investigations showed an abnormally high excretion of faecal fat in seven cases. Anaemias which are ;unexplained' or which show a suboptimal response to treatment should be investigated from the viewpoint of intestinal dysfunction. Such anaemias are not a particularly uncommon problem.
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The experience gained in the investigation of 100 cases of cardiac surgery treated by use of extracorporeal circulation has shown that certain simple laboratory tests suffice to detect induced defects in the blood and to guide therapy. These tests have been devised to detect the level of circulating heparin during perfusion; the presence of residual heparin following perfusion; the existence of a qualitative or quantitative fibrinogen deficiency; excessive fibrinolysis. Any of the latter three abnormalities alone or together have caused excessive immediate post-operative blood loss. Specific therapy has not been found to be necessary unless severe bleeding occurs.
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Red cells, derived from 13 patients with iron-deficiency anaemia, were found to have a normal life span in the patients' own circulations and those of normal volunteers.
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