Biomedical subjects

A A Scaduto

Publications and source records attributed to A A Scaduto.

4 recordsLinked to original sources

PubMed2000

Symptomatic osteonecrosis of the hip after orthotopic liver transplantation.

Patients who require long-term steroid use for immunosuppression after organ transplantation are at risk for the development of osteonecrosis. The purpose of this study was to determine the prevalence of symptomatic osteonecrosis of the hip in patients who were managed with corticosteroids for immunosuppression after orthotopic liver transplantation. We reviewed the relationship of the administration and dosage of steroids in 203 patients who underwent orthotopic liver transplantation. Overall, 29 of the 203 patients (14%) complained of hip pain, but only 3 patients (2%) developed symptomatic osteonecrosis of the hip. The osteonecrosis was diagnosed an average of 31 months after transplantation (range, 26-38 months). There was no association noted between steroid dose and the development of osteonecrosis. Routine screening for osteonecrosis of asymptomatic liver transplant patients is not necessary.

Adrenal Cortex Hormones↗

PubMed2000

Accessory soleus muscle as a cause of resistance to correction in congenital club foot: a case report.

A 14-month-old female with bilateral clubfeet was initially treated by serial casting and percutaneous tenotomy of the Achilles tendon, bilaterally. Both clubfeet subsequently underwent surgical treatment with a posteromedial release through a Cincinnati incision. At surgery on one clubfoot, an accessory Soleus muscle was found anterior to the Achilles tendon with a distinct insertion on the upper surface of calcaneus, anterior and medial to the insertion of Achilles tendon. This accessory Soleus muscle may have been the cause of resistance to correction in this congenital clubfoot.

Abnormalities, Multiple↗

PubMed2000

Lacerations and ruptures of the flexor or extensor hallucis longus tendons.

Lacerations and ruptures of the flexor hallucis longus or extensor hallucis longus tendon are frequently managed with operative repair. Tendon injuries of the hallux are not all alike; careful consideration should be given to the mechanism and site of injury, the timing of presentation, and the presence of other injuries. Not all tendon injuries of the hallux require repair. The effectiveness of a repair will depend on the goals of surgery, which may include pain relief, active joint motion, or correction of deformity. When goals are clearly defined, a satisfactory result can be expected in most patients.

Foot↗

PubMed1999

Gene therapy for osteoinduction.

One application of gene therapy that holds great promise is the stimulation of bone formation. Gene therapy offers several potential advantages over other methods of osteoinduction and current research suggests that it may be a feasible treatment option for the orthopedic surgeon in the near future. This article reviews the basic concepts and strategies of gene therapy and evaluates the current research using gene therapy to induce bone formation and enhance healing.

Bone Marrow Cells↗