Ultraviolet B phototherapy for psoriasis in sunlight-responsive patients.
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Body Surface Area↗
Biomedical subjects
A A Schothorst
Publications and source records attributed to A A Schothorst.
A biochemical screening test for the photosensitizing potential of drugs and disinfectants.
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Amino Acids↗
[Experience with photochemotherapy with 8-methoxypsoralene by mouth and long-wave ultraviolet light (PUVA-treatment) in psoriasis].
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Adolescent↗
In vitro studies on the protoporphyrin uptake and photosensitivity of normal skin fibroblasts and fibroblasts from patients with erythropoietic protoporphyria.
Fibroblasts derived from patients with erythropoietic protoporphyria (EPP) are not sensitive to violet light and do not contain an excess of protoporphyrin (PP). Fibroblasts from both normal individuals and patients with EPP can take up very low concentrations of PP from culture medium. Cells grown in PP-containing medium showed a gradually increasing but limited uptake of PP and also an increased sensitivity to light. A sensitive scanning microfluorometric method has made it possible to demonstrate that the PP is mainly localized in the perinuclear granules. After exposure to violet light, cells photosensitized by PP in a culture medium showed increased membrane permeability as well as reduced reproductive capacity. Both of these photodamage effects can be repaired during postirradiation incubation in culture medium at 37 degrees C.
Cell Division↗
Difference in the efficiency of two delivery forms of 8-methoxypsoralen.
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Administration, Oral↗
The role of oxygen in the photodamaging effect on erythrocytes of some photoallergic and phototoxic compounds.
Red blood cells irradiated with longwave ultraviolet light in the presence of a number of photoallergic or phototoxic compounds showed a marked loss of K+ ions. This process was strongly restricted by anaerobic conditions. During irradiation, oxygen was consumed. Since pre-irradiated photosensitizers were not toxic to erythrocytes, it is concluded that during irradiation, oxidative processes take place in the erythrocyte. The concentrations of the investigated photoallergic compounds required to induce photohaemolysis, were several times higher than those required for the phototoxic compound protoporphyrin. These findings indicate that photoallergic compounds, like the photodynamic compounds, also have photo-oxidative capacities, but to a much lower degree.
Erythrocytes↗
[The treatment of psoriasis with oral 8-methoxypsoralen and long-wave ultraviolet light].
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Humans↗