PubMed Health⌕ Search

Biomedical subjects

A A Selivanov

Publications and source records attributed to A A Selivanov.

At least 19 recordsLinked to original sources
PubMed1992

[The diagnostic value of different test systems for the screening determination of antibodies to the human immunodeficiency virus].

Evaluation of the quality of enzyme immunoassay (EIA) systems by their sensitivity and specificity is inadequate, mainly due to the impossibility of detecting early or latent HIV infection in humans as it manifests by seroconversion only to a few HIV proteins. The additional evaluation criterion (confirmation rate) has been introduced, and an original method for the integral evaluation of the quality of assay systems intended for the diagnosis of HIV infection by EIA techniques has been proposed.

Evaluation Studies as Topic↗
PubMed1984

[Effect of repeated immunization with inactivated influenza vaccine on the formation of specific and nonspecific immunity factors].

A group of young people, totaling 1160 persons, was immunized annually with influenza inactivated chromatographic divaccine prepared from influenza viruses A (H1N1 +/- H3N2) for 3 years. Only in persons immunized once or twice direct correlation between the number of immunizations and their immunological effectiveness was observed. Repeated immunization produced no stimulating effect on the level of systemic humoral and secretory immunity. The innocuity of repeated vaccinations is substantiated by the absence of such effect on the somatic morbidity of the vaccinees and the levels of complement, lysozyme and beta-lysin in the blood serum.

Adolescent↗
PubMed1970

Testing the safety and effectiveness of oral administration of a live influenza vaccine.

Tests to determine the reactogenicity and immunogenicity of a live influenza vaccine when administered by mouth showed that the new method caused no reactions in adults and children and was adequately immunogenic, the results being in no way inferior to those obtained by intranasal administration. These results provide a basis for the wider use of this simpler and more convenient method of administration.Oral administration of the live influenza vaccine was followed by reproduction of the vaccine virus. The rapid elimination of catarrhal symptoms existing before vaccination indicates intensive production of interferon in the nasopharynx of the vaccinated persons.The standard influenza vaccine for adults induced strong reactions in children, even when the less dangerous oral route of vaccination was used. For oral vaccination of children it is thus essential to use the variant of the live influenza vaccine made from further-attenuated, cold-adapted vaccine strains of influenza virus. This vaccine is quite safe and effective whether administered intranasally or by mouth.

Adult↗