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A A Simonian

Publications and source records attributed to A A Simonian.

23 records · Page 2Linked to original sources
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[Synthesis of proteins in heart mitochondria during postnatal development of the rat].

Proteins of inner mitochondrial membranes of the albino rat myocardium during postnatal development of 1, 3 and 6 months old animals were electrophoretically separated in 10% polyacrylamide gel. The rate of 14C-amino acids incorporation into examined proteins was determined in vitro. Specific radioactivity of the total mitochondrial fraction decreased in the course of the postnatal development. That of outer membranes remained unchanged, though it sharply increased in inner membranes of mature animals as compared with animals aged one month. Levels of radioactive precursor incorporation in separate protein fractions of inner membranes of the myocardium mitochondria were estimated.

Aging↗
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[A comparative ontogenetic study of respiration and oxidative phosphorylation of chicken myocardium mitochondria].

When adding alpha-ketoglutarate and glutamate the intensity of respiration by the myocardium mitochondria increases gradually from the 15th day of embryonic development till the chicken hatching out. In the presence of succinate respiration of mitochondria of 15- and 20-day embryos and 5-day chickens is almost the same and decreases noticeably in adult chickens. When the above-mentioned substrates are added the value of P/O gradually decreases during the chicken development.

Animals↗
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[Alpha-ketoglutarate carboxylation in brain and liver subcellular fractions of the hen during ontogeny].

Studies have been made of the role of NADPH and NADH in carboxylation of alpha-ketoglutarate to isocytrate in the cytoplasm and mitochondria of the brain and liver in ontogenesis of hens. In both fractions of the liver, the reaction in the presence of NADPH is more intensive than that in the presence of NADH, being more intense in the cytoplasm than in mitochondria; during embryogenesis, the rate of the reaction increases up to hatching, decreasing at later stages of ontogenesis. No significant changes in the rate of carboxylation were observed during ontogenesis in the presence of NADH. In the brain, the reaction rate in the presence of NADH is higher than that in the liver, being lower in the presence of NADPH. In contrast to that in the liver, NADPH-dependent reaction in the brain is more intensive in mitochondrial fraction. The rate of both reactions, after the initial increase in embryogenesis, decreases at early postnatal stages, except NAD-dependent reaction which is sharply increased in brain cytoplasm of adult hens.

Animals↗
PubMedDate not supplied

[Intracellular distribution of NADP-dependent isocitrate dehydrogenase activity in the tissues of chickens in ontogeny].

The distribution of activity of NAD . P-dependent isocitrate dehydrogenase in the chick liver and brain cytoplasm and mitochondria was studied during ontogenesis. A marked increase of its activity was found in both liver fractions during embryogenesis, with the predominance in mitochondria; the major part of its activity during postembryonic development is localized in the cytoplasm. In the brain tissues where this enzyme is less active in both the factions its activity increased to a greater extent in the mitochondria and exceeded markedly that in the cytoplasm.

Aging↗