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Biomedical subjects

A A Snisarenko

Publications and source records attributed to A A Snisarenko.

8 recordsLinked to original sources
PubMed1986

Cardiac rhythm in cats during physiological sleep in experimental myocardial infarction and beta-adrenergic receptor blockade.

The authors investigated parameters of the sinus rhythm and of the structure of physiological sleep in 11 cats after ligation of the interventricular artery. ECG of the cerebral cortex, electromyogram, electrooculogram, ECG and respiration were registered, both in the acute period of infarction (4th-10th day of the experiment) and in the subacute and late period (3-12 months). In the acute and subacute period, an abrupt decrease was found in the sinus rhythm variability during the waking-sleep cycle. Propranolol administration (10 mg/kg) reduced in intact animals the heart rate, especially during wakefulness, and the rhythm variability during wakefulness and sleep. Suppression of sinus rhythm automatism due to propranolol in animals with experimental MI was most pronounced in the acute period during REM sleep, in the subacute period during wakefulness. In the acute period of MI, the sleep structure was disorganized, in the subacute period it got partly normalized. Protracted propranolol administration in the subacute period of MI led to disturbances in the sleep structure, with reduced REM sleep and prolongation of stage I-II (superficial sleep).

Adrenergic beta-Antagonists↗
PubMed1976

[Changes in the cardiac and "sleep--wakefulness" cycle rhythms following isoproterenol administration to white rats].

The heart-rate during sleep-wakefulness cycle did not significantly change after isoproterenol administration. However, both the duration of R--R intervals and their dispersion became sharply increased. The observed shifts were least obvious during the slow-wave sleep. The bradycardia periods during paradoxical sleep in rats are supposed to be a beneficiary background for further suppresion of the sinus automatism up to sinoauricular blockade. The data obtained suggest that the heart-rate during wakefulness can be a reliable enough evidence of its oscillations in other phases of the cycle. The revealed changes of the sleep structure involved increasing part of paradoxical stages in the total time of sleep in animals when measuring it starting from the 5th day after the sympathomimetic administration.

Animals↗