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Biomedical subjects

A A Soriero

Publications and source records attributed to A A Soriero.

4 recordsLinked to original sources
PubMed1980

Autoradiographic study of the effects of estrogen on in vivo incorporation of 3H-uridine into uterine smooth muscle and stromal RNA in the aging ovariectomized mouse.

An autoradiographic study was made of de novo RNA synthesis and nuclear area in endometrial stroma and myometrium in ovariectomized C57B1/6J mice. A comparison of uterine tissue from young adult (4 to 7 month old) mice was made with tissue from animals of the age of decreased fertility (15 months of age). In mice receiving exogenous estradiol-17 beta there was an age related decrease in nuclear grain counts 60 min after injection of 3H-uridine which was more pronounced in endometrial stroma than in myometria when mice were compared with oil injected controls of the same age. The mean nuclear area of both cell types was greater in estrogenized mice than in control mice. The decrease in endometrial stromal response to exogenous estrogen is consistent with, and may contribute to, decreasing fertility with advancing maternal age.

Aging↗
PubMed1975

Intrauterine instillation of prostaglandin F2ALPHA IN EARLY PREGNANCY.

Intrauterine PGF2alpha (5mg) was administered for termination of early pregnancy in 14 healthy volunteers. With 11 complete abortions, the efficiency rate of this technique is below conventional methods. In addition, the incidience of infection was high occuring in 12 out of 14 subjects. Because of persistent bleeding, six patients underwent a dilatation and curettage. Other significant side effects included transient hypertension, pain, nausea and restlessness. In the patients with a complete abortion, the mean plasma progesterone concentration fell 37% after 8 hours post PGF2alpha instillation and 90iod and 75% over the next 14 days.

Abortion, Induced↗
PubMed1975

The effect of estrogen on protein and RNA concentration and on de novo synthesis of RNA in the uterus of aging ovariectomized mice.

A study was made of RNA concentration and de novo synthesis and protein concentration in the uterus of ovariectomized C57BL/6J mice with and without estrogen treatment. Young adult animals (4 to 7 mo.) were compared with mice during the age period of reproductive decline (11 and 15 mo.). Concentration of RNA was significantly lower in 15-mo.-old mice than in 4- to 7- and 11-mo.-old animals. De novo RNA synthesis, as indicated by incorporation of 3H-uridine, was also lower in 15-mo.-old mice than in young adults. Estradiol -17beta increased RNA concentration at all ages studied and the percentage increase did not decline with age. De novo synthesis of RNA was also increased in response to estrogen treatment, but the response was less in 15-mo.-old mice. Protein concentration did not change with age, but the concentration decreased in the estrogen treated mice. The biochemical changes in the uterus may be associated with the declining ability of this organ to support pregnancy as it grows older.

Aging↗