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A A Spasov

Publications and source records attributed to A A Spasov.

7 recordsLinked to original sources
PubMed1990

[Method of studying the effects of pharmacological substances on work capacity of animals in hypobaric hypoxia].

The method of the study of medical agent influence and biological active substances on duration of small laboratory animals swimming has been worked out excluding the air. For this purpose the animals were placed into altitude chamber, filled with water by 1/3 (one-third) of its volume being in antiorthostatic position on dipping into water. It has been established that at the altitude of 4000 (four thousand) meters high the rat swimming duration became shorter in comparison with their work under normal pressure in 2.5-4 times. Bemitil stimulating work in hypobaric hypoxia depresses it sharply. Bemitil stimulating influence on the rat efficiency did not appear with rising. Antioxidant substance ionol increased efficiency in normal conditions and in hypoxia AKS-85 adaptogenic compound increased swimming in the height duration to a greater degree, mildronat substance for efficiency restoration produced actoprotective influence.

Amphetamine↗
PubMedDate not supplied

[Effect of ethyron on carbohydrate metabolism in the myocardium].

Tests staged on rats showed the hypertensive drug ethyron (ethylisothiuronium) to intensify the activity of the oxidative system and pentose cycle in the myocardium, to increase the pyruvate content, raise the redox potential of the lactate-pyruvate potential, to reduce the amount of lactate, heighten the activity of the lactate, malate dehydrogenases, glucose-6-phosphate and cytochrome-c-oxydase. In an isolated spontaneously contracting atrium ethyron abolished the suppressing effect of carbohydrate metabolism inhibitors (sodium fluoride and copper sulphate) on the intensity and frequency of contractions.

Animals↗
PubMedDate not supplied

[Mechanism of the cardiotoxic action of No-Spa].

Tests set up in vivo on rats and with an isolated spontaneously contracting atrium of the cat brought evidence that nospanum produces an adverse chronotropic action, caused by a direct effect on the cardiac pacemaker. In the rat's myocardium the drug raised the pyruvate level, increased the lactate-dehydrogenase activity and depressed that of glucose-6-phosphate-dehydrogenase. As established by differential spectrophotometry the reduced forms of pyridine-nucleotides (NAD'N, NADP'N) tend to change the nospanum spectrum. An addition of potassium chloride to an isolated atrium at the peak of the adverse chronotropic action of nospanum or an introduction of nospanum together with NAD'N abolished the cardiotropic effect of the drug. The mechanism of the cardiotoxic action of nospanum is discussed.

Animals↗
PubMedDate not supplied

[The effect on gastric secretion and the anti-ulcer action of imidazo[1,2-A]benzimidazole derivatives].

The experiments on rats showed that of 16 studied imidazo [1,2-a]benzimidazole derivatives only the compounds with phenyl at the second carbon atom and nitrogen-containing radical of the ninth nitrogen atom inhibit the gastric acid secretion. The binding of oxymethyl group to phenyl, its substitution through adamantyl, displacement of nitrogen-containing substitute to the first nitrogen atom or its substitution were found to decrease or stop the inhibiting action of these substances on the gastric parietal cells. Dihydrochloride 2-phenyl-9 (beta-diethyl-aminoethyl)imidazo [1,2-a]denzimidazole was more potent than cimetidine and omeprazole in inhibiting the gastric acid secretion, pepsin output and antiulcer action.

Animals↗
PubMedDate not supplied

[Influence of hypertensive substances on the kallikrein-kinin system of the blood].

It is shown that following a one-time intravenous administration to rats of ethyron, epinephrine and pituitrin (in doses causing hypertension) the amount of the blood plasma kininogen is more than halved with concurrently increasing caseinolysis. A two-day long introduction of these substances activates prekallicrein and brings down the level of the kallicrein inhibitors, whereas a 10 and 20-day coursewise administration of these compounds intensifies the synthesis of some components in the kallicrein-kinine system.

Animals↗