Biomedical subjects

A A Thomson

Publications and source records attributed to A A Thomson.

3 recordsLinked to original sources

PubMed1990

The progesterone receptor can regulate transcription in the absence of a functional TATA box element.

We have investigated the importance of the TATA box element in the induction of transcription by the progesterone receptor. Transcription was analyzed from promoters containing a steroid response element upstream of a wild-type or mutated TATA box. Mutation of the TATA box resulted in a loss of correctly initiated transcripts and abolished binding of TATA factor to the TATA box in vitro but did not inhibit transcriptional activation by the progesterone receptor. Thus we conclude that the receptor is able to stimulate the rate of transcription in the absence of a functional TATA box.

Animals↗

PubMed1979

A pattern of local recurrence following resection of colorectal cancer.

Twenty patients (10%) developed a local recurrence following 200 consecutive curative resections for colorectal carcinoma. Analysis of the pathology of the primary tumours suggests that invasion of adjacent tissues, and lymph node involvement, were more important presection on the mucosa. The average time interval between resection and diagnosis of local recurrence was 17 months. The average survival time following diagnosis was 10 months. Nineteen out of 20 of these patients developed evidence of disseminated disease subsequent to the diagnosis of local recurrence. The most effective palliation occurred in patients in whom the local recurrence could be resected.

Colonic Neoplasms↗

PubMed1978

Split cuff ileal stoma.

Long-term patient comfort after an ileal conduit urinary diversion depends on the conduit stoma. The problem of leak-proof urine collection of the flush stoma can be overcome by using a spout stoma but this could become stenotic unless everted. Eversion is a technically difficult procedure and produces a bulky spout that tends to prolapse. The use of carefully placed myotomies in the split cuff stoma described herein facilitates eversion and produces a slim stoma that accepts a compact, leak-proof appliance and is, at the same time, free of the complications of stenosis and prolapse in the long-term management.

Humans↗