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Biomedical subjects

A A Zwarun

Publications and source records attributed to A A Zwarun.

5 recordsLinked to original sources
PubMed1991

Future directions of laser phototherapy for diagnosis and treatment of malignancies: fantasy, fallacy, or reality?

A new and highly promising adjunctive modality for the diagnosis and therapy of malignancies is under development using lasers and tumor targeting dyes. To reach the eventual goal of clinical treatment, several current "fantasies and fallacies" regarding laser applications in medicine must be identified and their problems clearly outlined. A multidisciplinary scientific approach is also required to enable the clinical practicality of this laser targeting approach. Many new dyes and laser wavelengths are being tested to improve specific tumor uptake and/or retention, lower systemic toxicity, increase tissue penetration, and identify fluorochromes with synergistic properties to further enhance laser tumoricidal effects. Rapid technological advancements in magnetic resonance imaging may now provide an extremely sensitive way to detect and monitor laser-tissue effects, and allow efficient interstitial laser phototherapy of deep and sometimes inaccessible tumors. The current and future prospectives of the emerging field of laser phototherapy are described.

Coloring Agents↗
PubMed1979

Development of an 82.2 degrees C (180 degrees F) temperature indicatior system for monitoring equipment washing and sanitizing programs.

A survey performed at 12 institutions showed that while the temperatures in the water tanks of mechanical cage washers were monitored, these temperatures deviated from the temperatures obtained on the items actually being washed. Most surveyed facilities were not meeting the 82.2 degrees C (180 degrees F) standard in the washing chamber. A temperature indicator was developed which revealed whether 82.2 degrees C had been reached at the surface of the items being sanitized. The indicator was a sealed glass ampule which produced a visible color change when exposed to temperatures of 82.2 degress C or higher. The indicator was located on the items being washed. Due to the variability of water heating in washing machines, it was recommended that one indicator be used in each load of equipment being sanitized.

Animals↗
PubMed1975

Measurement of redox potential changes in anaerobic culture media caused by addition of blood.

A method has been described whereby the redox potential of unsealed and manipulated samples of solution can be determined. This method includes treating the platinum electrode with strong cleaning solution, adjusting the electrode with a culture of Proteus vulgaris in tryptic soy broth, and doing all manipulations inside a glove box that is continuously flushed with oxygen-free gas. This study has shown that prereduced media are much more reduced than media which have been dispensed only under a partial vacuum. It also has shown that addition of blood to prereduced medium does not eliminate the strongly reducing condition of the medium although there is a slight rise in redox potential.

Anaerobiosis↗
PubMed1973

Effect of osmotic stabilizers on 14 CO 2 production by bacteria and blood.

Evolution of (14)CO(2) by whole blood as well as by Diplococcus pneumoniae, Haemophilus sp., Pseudomonas aeruginosa, Pseudomonas diminuta, and Streptococcus pyogenes was examined by using the BACTEC system. The control medium was JLI no. 6A culture vial containing 30 ml of enriched tryptic soy broth and 1.5 muCi of (14)C-substrate. Hypertonic media consisted of control medium with either 1 or 3% NaCl, 10% sucrose, and 5%, 10%, or 15% dextran. The most deleterious treatment to bacteria was 3% NaCl since it not only retarded (14)CO(2) production, but also prevented growth of D. pneumoniae, Haemophilus, and P. diminuta. The 10% sucrose treatment diminished (14)CO(2) output, although it did not retard growth of test organisms. This effect was probably due to (14)C-substrate dilution rather than to osmotic effects. Dextran had slight effect on (14)CO(2) production and slightly acidified the medium. Of the treatments tested, only 10% sucrose reduced normal output of (14)CO(2) by whole blood. This also is probably due to (14)C-substrate dilution. It appears that 10% sucrose is potentially the most useful osmotic agent for radiometric techniques since, although bacterial (14)CO(2) production is lowered, blood (14)CO(2) is lowered also.

Bacteria↗