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Biomedical subjects

A A el-Banna

Publications and source records attributed to A A el-Banna.

16 recordsLinked to original sources
PubMed1993

Effect of indomethacin administered during the normal time of implantation on the progesterone and protein composition of plasma and uterine flushings of rabbits.

The present experiment was designed to investigate the mode of action of indomethacin, a prostaglandin synthesis inhibitor, as an antifertility agent, and to examine a possible effect of indomethacin administered during the normal peri-implantation period on the protein content and progesterone concentration in plasma and uterine fluid in pseudopregnant rabbits. The results showed that treatment with indomethacin significantly reduced the plasma progesterone concentrations, decreased progesterone concentrations in uterine flushing, significantly decreased the total plasma proteins, and particularly decreased albumin in the plasma and in the uterine flushings. Uteroglobin production by the rabbit uterus was not affected by this treatment. It is concluded that the antifertility effect of indomethacin at the time of implantation is exerted by reducing progesterone concentrations in plasma and uterine fluid, possibly affecting steroidogenesis, and by reducing the percentage of albumin in plasma and in uterine fluid, probably by increasing renal excretion of albumin. These effects of indomethacin provide an environment within the uterus that would not support embryo implantation and development.

Animals↗
PubMed1990

Effect of gonadal steroid hormones on the metabolic rate of the cold-acclimated gonadectomized male and female Chalcides ocellatus (Forskal).

Male and female Chalcides ocellatus were gonadectomized and cold acclimated at 15 degrees for 1 week. Lizards were injected with testosterone and estradiol, and their oxygen consumption was determined at 15 degrees. Testosterone and estradiol caused a significant increase in the whole body rate of oxygen consumption in male and female lizards, respectively.

Acclimatization↗
PubMed1988

Production of penitrem A by Penicillium crustosum isolated from foodstuffs.

Sixty one isolates of Penicillium crustosum originating from various foodstuffs were screened for penitrem A production by thin-layer chromatography. The highest producers of penitrem A (4 isolates) were grown in various liquid media. Skimmed milk (2%)/potato extract (2%)/sucrose (2%) (SPS) medium supported the highest toxin production and P. crustosum Sp 1552 was selected as the best producer of penitrem A. Optimal conditions for the production of penitrem A were to grow the isolate Sp 1552 (stationary) in 100 ml of SPS medium (with 4% sucrose) in 500-ml flasks for 3 weeks at 25 degrees C with initial pH 5.7. The isolation and purification of penitrem A is described. Approximately 246 mg of pure penitrem A was obtained from 200 flasks each containing 100 ml of SPS medium.

Culture Media↗
PubMed1987

Effect of indomethacin on plasma levels of vitamin D metabolites, oestradiol and progesterone in rabbits during early pregnancy.

1. Inhibition of prostaglandin (PG) synthesis by indomethacin (Id) during early pregnancy in rabbits apparently disrupts the process of sex steroid production by the ovaries. 2. The role of PGs as mediators in steroidogenesis was tested by investigating the effect of Id alone or in combination with progesterone, with oestradiol and progesterone, or with a mixture of PGs, on plasma levels of 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) in rabbits at an early stage of pregnancy. 3. Id alone significantly reduced plasma levels of both 25(OH) D and 1,25(OH)2D. Treatment with Id in combination with either oestradiol and progesterone, or with a mixture of PGs, resulted in the restoration of plasma levels of both vitamin D metabolites as well as the restoration of plasma levels of progesterone, to their control values.

Animals↗
PubMed1986

Treatment with prostaglandins reduces the antifertility effect of indomethacin in rabbits.

Indomethacin (Id) treatment of rabbits at the time of implantation resulted in a significant reduction in the number of viable embryos as well as significant reduction in plasma progesterone concentrations. Treatment with a mixture of prostaglandins (PGs) together with Id caused a significant increase in both the number of viable embryos and in plasma progesterone concentrations when compared to the treatment with Id alone. The PG mixture used in the present study did not succeed in fully reversing the Id antifertility effect.

Animals↗