EFFECT OF ADRENALECTOMY ON COTTON PELLET GRANULOMA FORMATION IN THE RAT.
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Biomedical subjects
Publications and source records attributed to A ASHFORD.
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Twenty-one pairs of parallel assays of corticotrophin are reported, in which results from hypophysectomized rats are compared with those from hydrocortisone-treated animals. The two methods show little difference in respect of potency, precision and limits of error.
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A single injection into the rat of chlorpromazine, reserpine, benactyzine or phenobarbitone stimulates the release of corticotrophin. This effect is not seen after the drugs have been injected daily for 5 days, nor when the rats are hypophysectomized or pretreated with hydrocortisone. The stimulant effect of ether on corticotrophin release is not modified by pretreatment with a single injection, nor to any great extent after 5 daily injections of these drugs.