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Biomedical subjects

A Acín

Publications and source records attributed to A Acín.

11 recordsLinked to original sources
PubMed2005

Experimental methods for detecting entanglement.

Here we present experimental realizations of two new entanglement detection methods: a three-measurement Bell inequality inequivalent to the Clauser-Horne-Shimony-Holt inequality and a nonlinear Bell-type inequality based on the negativity measure. In addition, we provide an experimental and theoretical comparison between these new methods and several techniques already in use: the traditional Clauser-Horne-Shimony-Holt inequality, the entanglement witness, and complete state tomography.

Journal Article↗
PubMed2005

Quantum key distillation from Gaussian states by Gaussian operations.

We study the secrecy properties of Gaussian states under Gaussian operations. Although such operations are useless for quantum distillation, we prove that it is possible to distill a secret key secure against any attack from sufficiently entangled Gaussian states with nonpositive partial transposition. Moreover, all such states allow for key distillation, when Eve is assumed to perform finite-size coherent attacks before the reconciliation process.

Journal Article↗
PubMed2004

Coincidence bell inequality for three three-dimensional systems.

We construct a Bell inequality for coincidence probabilities on a three three-dimensional (qutrit) system. We show that this inequality is violated when each observer measures two noncommuting observables, defined by the so-called unbiased six-port beam splitter, on a maximally entangled state of two qutrits. The strength of the violation agrees with the numerical results presented by Kaszlikowski et al, quant-ph/0202019. It is proven that the inequality defines facets of the polytope of local variable models.

Journal Article↗
PubMed2004

Multipartite bound information exists and can be activated.

We prove the conjectured existence of bound information, a classical analog of bound entanglement, in the multipartite scenario. We give examples of tripartite probability distributions from which it is impossible to extract any kind of secret key, even in the asymptotic regime, although they cannot be created by local operations and public communication. Moreover, we show that bound information can be activated: three honest parties can distill a common secret key from different distributions having bound information. Our results demonstrate that quantum information theory can provide useful insight for solving open problems in classical information theory.

Journal Article↗
PubMed2001

Distillability, bell inequalities, and multiparticle bound entanglement.

We study the relation between violation of Bell inequalities and distillability properties of quantum states. Recently, Dür [Phys. Rev. Lett. 87, 230402 (2001)] has shown that there are some multiparticle bound entangled states which are nonseparable and nondistillable, that violate a Bell inequality. We prove that for all the states violating this inequality there exists at least one splitting of the parties into two groups such that some pure-state entanglement can be distilled, obtaining a connection between Bell inequalities and bipartite distillable entanglement.

Journal Article↗
PubMed2001

Statistical distinguishability between unitary operations.

The problem of distinguishing two unitary transformations, or quantum gates, is analyzed and a function reflecting their statistical distinguishability is found. Given two unitary operations, U1 and U2, it is proved that there always exists a finite number N such that U(x in circle N)(1) and U(x in circle N)(2) are perfectly distinguishable, although they were not in the single-copy case. This result can be extended to any finite set of unitary transformations. Finally, a fidelity for one-qubit gates, which satisfies many useful properties from the point of view of quantum information theory, is presented.

Journal Article↗
PubMed2001

Classification of mixed three-qubit states.

We introduce a classification of mixed three-qubit states, in which we define the classes of separable, biseparable, W, and Greenberger-Horne-Zeilinger states. These classes are successively embedded into each other. We show that contrary to pure W-type states, the mixed W class is not of measure zero. We construct witness operators that detect the class of a mixed state. We discuss the conjecture that all entangled states with positive partial transpose (PPTES) belong to the W class. Finally, we present a new family of PPTES "edge" states with maximal ranks.

Journal Article↗
PubMed2000

Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene.

Previously, we isolated the human AE2 (SLC4A2) gene, a member of the sodium-independent anion exchanger family. Rat ortholog of this gene was reported to drive alternative transcription yielding N-terminal variants of the AE2a message. We thus analyzed the human AE2 gene in this regard. Using HepG2 cells, two alternative first exons, each splicing to exon 3 in alternative transcripts, were found to be transcribed from overlapping sequences of intron 2. Exon 1b(1) corresponds to the rat variant "b" and encodes three initial residues (MTQ) in AE2b(1) isoform that replace the first 17 amino acids of AE2a protein, while the novel exon 1b(2) encodes eight initial residues (MDFLLRPQ) in AE2b(2) isoform. The relative abundance of AE2b(1) and AE2b(2) mRNAs was about 10% of AE2a mRNA each. Alternate promoter sequences have multiple potential binding motifs for liver-enriched factors, and dual-luciferase assays indicated that they possess the ability for driving transcription in transiently transfected HepG2 cells. Tissue survey showed that expression of human AE2b(1) and AE2b(2) transcripts is restricted to liver and kidney, while AE2a mRNA was encountered in all examined tissues. Our findings reveal a characteristic tissue-specific expression of two N-terminal variants of human AE2 from overlapping sequences within intron 2, one of which is a novel isoform.

Alternative Splicing↗
PubMed1999

Cloning and characterization of the 5' flanking region of the human uncoupling protein 3 (UCP3) gene.

Uncoupling protein 3 (UCP3), a member of the UCP family, mainly expressed in skeletal muscle could be responsible for thermogenesis in humans. Since little is known about its regulation, we studied the 5' flanking region of the human UCP3 (hUCP3) gene, which potentially contains the promoter sequences. We report the hUCP3 transcription initiation on a G located 764 nucleotides upstream the A contained in the first translated codon. Therefore, hUCP3 first exon has 669 bases of untranslated sequence. We also report the cloning and sequencing of seven kilobases from the gene 5' end and analyze the features of the potential proximal promoter. The MyoD family binding motif, called E-box, is the most abundant on this region. Other muscle-specific motives present in the potential proximal promoter include a MEF2 site as well as binding sequences for ubiquitous factors such as GC box and two CAAT boxes. Additionally, three putative peroxisome proliferator and one thyroid hormone response elements (PPRE and TRE, respectively) are found, which suggest a potential role for the peroxisome proliferator-activated receptor (PPAR) and thyroid hormone in human UCP3 gene expression. The description of the promoter region of the UCP3 gene will facilitate the elucidation of its transcriptional control.

Base Sequence↗
PubMed1997

Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene.

The human AE2 gene (HGMW-approved symbol SLC4A2) encompasses over 17 kb and contains 23 exons intervened by 22 introns. The size range for the exons is 90-255 bp, whereas that for the introns is 80 bp to 2.2 kb. Exon 1 consists solely of 5'-untranslated sequence, and exon 2 encodes the amino-terminal end of the antiport protein. Primer extension experiments suggest that there are multiple transcription initiation sites in leukocytes. The putative promoter region of the human AE2 gene contains no obvious TATA or CCAAT elements in the expected positions but has GC boxes, proposed sites for binding Sp1 transcription factor. These features, as well as the presence of several consensus elements such as GATA, LBP-1, E-box, CACC box, and T-antigen motif, indicate that the human AE2 promoter resembles the erythroid promoter of the human AE1 gene. The human AE2 gene (which has been previously mapped to chromosome 7) has three more introns than the human AE1 gene (mapped to chromosome 17), but downstream of intron 7 in the AE2 gene (corresponding to intron 4 in the AE1 gene), these two genes show a rather similar exon/intron organization.

Amino Acid Sequence↗