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Biomedical subjects

A Aderibigbe

Publications and source records attributed to A Aderibigbe.

3 recordsLinked to original sources

Cervical spinal tuberculosis with tuberculous otitis media masquerading as otitis externa malignans in an elderly diabetic patient: case report.

Extrapulmonary manifestation of tuberculosis (Tb), a medieval disease, occurs in every part of the body with varying degree of frequency but commonly in the pleural and lymph nodes. When it occurs in bones thoracolumbar vertebrae is the usual site of involvement. Other bones are less involved hence seldomly reported. This is true for other organs and parts of the body including larynx, pharynx nose and the middle ear. More importantly, isolated extrapulmonary tuberculosis without pulmonary involvement is uncommon. The case of a 65 year old Nigerian trader who presented with headache, chronic ear ache with otorrhoea, persistent neck pain and found to be diabetic on further evaluation is presented. She was hitherto managed as a case of otitis external malignans without any improvement but rather her clinical condition worsened with evidence of cervical vertebra destruction and multiple cranial nerve palsies without pulmonary tuberculosis. Prompt and effective response to anti tuberculosis drugs informed the diagnosis of tuberculosis of the cervical vertebra and tuberculous otitis media with multiple cranial nerve palsies. This case underscores the value of high index of suspicion, thorough and complete clinical evaluation in any patient with chronic symptoms and signs unresponsive to conventional treatment.

Aged↗

Glomerular function in sickle cell disease patients during crisis.

An 8 month prospective study was carried out in 20 adult sickle cell disease (SCD) patients 16 sickle cell anaemia (Hbss) and 4 sickle cell Hbc disease (Hbsc); who had vaso-occlusive crises within the study period to determine the extent of the effect of sickle cell crisis on glomerular function in SCD patients during crisis. The male: female ratio was 1:57 and their mean age was 21.1 +/- 7.9 years. Creatinine clearance (CCr), as an index of glomerular function, was determined at the pre-crisis, crisis, 2 and 4 weeks post-crisis and at the end of the study period. The mean values of their CCr dropped from 113.37 +/- 33.80mls/min at pre-crisis stage to 96.39 +/- 30.13mls/min during crisis (p < 0.001) indicating glomerular dysfunction. It improved significantly to 107.75 +/- 30.20mls/min at 4 weeks post-crisis (p < 0.001). There was no significant differences in the mean values of CCr at the end of the study (116.20 +/- 31.43mls/min) compared to the pre-crisis stage (p > 0.05). It is concluded that glomerular dysfunction in SCD patients during crisis is potentially reversible.

Acute Disease↗

Arterial blood pressure in adult Nigerian sickle cell anaemia patients.

Sickle cell disease (SCD) is predominantly a problem of black community in whom a higher prevalence of hypertension has been reported. Despite these observations, a lower mean arterial blood pressure is observed to be common in homozygous sickle cell anaemia (SCA) patients, especially from outside Africa. In view of the well known diversity in both clinical and haematological presentations of SCD, we have evaluated the effects of sickled haemoglobin on blood pressure distribution in Nigerians with SCA. Arterial blood pressure was measured using mercury sphygmomanometer and the mean arterial pressure calculated in 64 adult Nigerians with SCA and 60 normal individuals. The mean age of SCA group was 22.14 +/- 4.90 years with a range of 18-57 years and in the controls was 27.18 +/- 8.06 years with a range of 18-54 years. The mean values of MAP 72.69 +/- 7.30 mmHg in SCA was significantly lower than 87.25 +/- 9.98 mmHg in the controls p < 0.007. The cause of this observed lower blood pressure in SCA is still speculative. We postulate that the differences in weight between SCA patients and normal individuals may contribute to this phenomenon. However, it is possible that nitric oxide (NO) or endothelial relaxing factor (EDRF) may also contribute to this lower blood pressure and the decrease in peripheral resistance in SCA.

Adolescent↗