PubMed HealthSearch

Biomedical subjects

A Agboola

Publications and source records attributed to A Agboola.

9 recordsLinked to original sources

Trophoblastic neoplasia in an African urban population.

A clinical study of trophoblastic neoplasia in a Nigerian population in Lagos over a four-year period is reported. A high incidence of one in 379 deliveries for benign trophoblastic tumor and one in 846 deliveries for malignant tumor was found. Seventeen percent of benign trophoblastic tumors in this series progressed to the malignant type, but malignant trophoblastic tumor was preceded by the benign type (hydatidiform mole) in 46 percent of cases. The anterior vaginal wall is a common site for metastases of malignant trophoblastic neoplasia and, in one patient, the lesion progressed further to form a vesicovaginal fistula. While the management of benign disease was conservative, all cases of malignant trophoblastic neoplasia received chemotherapy.

Adolescent

Effect of type and duration of anemia on placental weight and villous histology.

The effect of anemia during pregnancy on placental weight and villous histology has been studied in a group of Nigerian women. It has been shown that the weight of the placenta is not dependent on the type or duration of anemia that is present. Neither is there a correlation between these two aspects of anemia and the histological feature of villous fibrosis, which is an earmark of the placenta in anemia.

Anemia

The water and nitrogen composition of the placenta in anemic women.

A study was conducted to determine the water and nitrogen content of the placentae from anemic and nonanemic Nigerian women. The mean water content values were 84.9% and 85.3%, respectively, and this difference was not statistically significant. Placental nitrogen values were higher in anemic women than they were in nonanemic women, but the difference was not statistically significant. The results of this study indicate that placental hypertrophy which is associated with anemia is not due to water retention by the placenta.

Anemia

The effect of low haematocrit on serum human placental lactogen values.

Serial determinations of serum human placental lactogen (HPL) levels in women with haematocrit values of 28 per cent or less between 18 and 30 weeks gestation have been compared with the controls who had haematocrit values of 35 per cent or more. The women with low haematocrit values were found to have significantly raised HPL levels throughout the period of study. The placenta was significantly heavier in the anaemic group (P less than 0.01) but there was no significant difference in birth weights of the infants. It would seem that caution should be exercised in using HPL values as an index of placental function in anaemic women.

Anemia

A reappraisal of the duration of labor.

The mean, median, and modal durations of labor have been established following a prospective study of 602 consecutive labors. The mean duration of labor for primiparae was 14.92 hours, while the median and modal durations were 13.20 and 9.66 hours, respectively. The corresponding figures for multiparae were 10.02, 9.28, and 7.80 hours, respectively. There was a statistically significant difference in the mean duration of labor in the 2 groups of patients (P less than 0.001). A significant positive correlation has been observed between the duration of the first stage of labor and the second stage of labor (P less than 0.001), and this might be of clinical importance. It has been suggested that the median and modal durations of labor may be more representative and informative than the mean or average.

Adult

Correlates of human umbilical cord length.

In this study of the umbilical cord lengths of 602 Nigerian infants delivered at term, the mean, median and modal measurements were 57.48, 57.71 and 68.00 cm, respectively (range = 20-100 cm). There was a significant positive correlation between cord length and fetal weight (r = 0.2177, p less than 0.001) and also between cord length and placental weight (r = 0.2504, p less than 0.001). Other fetal and maternal variables studied did not correlate with cord length. Further investigations of the factors responsible for the growth of the umbilical vessels are needed.

Birth Weight