Biomedical subjects
Publications and source records attributed to A Agostini.
A sample of 103 Italians was tested for HLA-DQA1 polymorphism using the polymerase chain reaction (PCR) and dot blot hybridization. Results were in Hardy-Weinberg equilibrium. The power of discrimination was 0.91 and the rate of exclusion 56.7. The frequencies of the DQA1*0201 and DQA1*0301 alleles were found to be significantly different from other Caucasian populations.
The PCR method has been applied to amplify a Variable Number Tandem Repeat (VNTR) sequence located at the 3' end of the apolipoprotein B (ApoB) gene. The study was conducted on an Italian population sample and in a 3-generation family of 13 members, whose relationships were previously established using conventional blood systems. The allele frequencies found were compared with those reported in the literature. The results also confirmed the Mendelian inheritance of the alleles and the suitability of the PCR method for forensic purposes.
Using the method of paired comparisons, pairs of simultaneous horizontal or vertical lines, with one line above and one below or one on the left and one on the right of a fixation point, respectively, were presented tachistoscopically for length comparison. Space errors were found to have a pattern similar to that of time errors. The tendency to guess the comparative response from the absolute magnitude of stimuli is proposed as a basis for time and space errors. Manipulation of attentional scanning, which implies a more frequent usage of this guessing strategy for one of the two lines in a pair, was shown to affect space errors.
A longitudinal investigation developed in the Regione Veneto has focused on the motivations which lead 2,500 young people per year to choose the nursing school and on the information on the school and the profession which are available for them. The ground motivations which seem to guide to choice appear to be mostly of the idealistic-humanitarian type, while the image of the nursing profession shares the characteristics of a low professional and social role. The investigation has also explored the motivations which lead 15% of the candidates to leave the school very early on, and provides a profile of those characteristics of the Regional Schools which are judged by the young candidates as positive or negative.
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Human platelets were separated into 2 density populations by repeated centrifugations of platelet-rich plasma at increasing gravitational force. The heaviest platelet fraction was rich in larger platelets. The lightest platelet fraction was rich in smaller platelets. In both fractions and in the platelet button, lipid peroxidation (malonaldehyde-MDA-production after addition of thrombin) was measured at basal condition, on the 1st, 3rd, 5th, 7th and 9th day after aspirin ingestion. At basal conditions and after ingestion of aspirin, MDA production was higher in the heavy-large platelets than in light-small ones, but a parallel increase of MDA production was observed in the light and in the heavy population and in the platelet button. The data are not compatible with the hypothesis that platelet density and size are age-related. Aspirin inhibits platelet lipid peroxidation by permanently acetylating their cyclooxygenase and if the heaviest platelets were the young ones, lipid peroxidation should reappear sooner in them.
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