Biomedical subjects

A Al-Sulaiman

Publications and source records attributed to A Al-Sulaiman.

3 recordsLinked to original sources

PubMed1999

Stroke in Saudi children.

This study reports the clinical features and neuroimaging correlates of stroke in Saudi children seen over a 5-year period at the King Fahd Hospital of the University, Al-Khobar, Saudi Arabia. During the study period, 31 (18 boys, 13 girls; mean age, 26.2 months) of the 20,895 children seen had stroke; the annual stroke incidence was 29.7 per 100,000 in the pediatric population. Ischemic strokes accounted for 90% and hemorrhagic 10% of the cases, respectively. The boys-to-girls ratio for ischemic stroke was 2:1. Cranial computed tomographic scans and magnetic resonance imaging findings were abnormal in 82% and 91%, respectively. The etiologic factor was undetermined in 65% of the cases. Our results suggest that stroke is uncommon in Saudi children. However, further studies evaluating a larger population in different clinical settings are required to provide a more comprehensive picture of stroke in children in this area.

Cerebrovascular Disorders↗

PubMed1986

The influence of skeletal muscle reinnervation on experimentally induced myotonia.

Earlier studies have shown that prior denervation of muscle prevents myotonia induced by 2,4-dichlorophenoxy acetic acid (2,4-D) both in vivo and in vitro. This work studied the effect of reinnervation on 2,4-D myotonia. Twenty Sprague-Dawley rats were injected with 2,4-D at specific intervals following unilateral sciatic nerve crushing; the gastrocnemius muscle on both sides was studied electromyographically to assess myotonia and to document denervation and reinnervation. All the rats gradually became amyotonic following denervation; myotonia reappeared during reinnervation. Myotonic discharges were no longer detectable 1 week after nerve crushing, but returned completely within 3 weeks. Blocking axoplasmic transport with colchicine had essentially the same effect on myotonia. A reciprocal temporal relationship was noted between the occurrence of fibrillations and myotonic discharges. These findings substantiate the view that innervation is essential to maintain the muscle membrane in a state that will support myotonic discharges.

2,4-Dichlorophenoxyacetic Acid↗

PubMedDate not supplied

Electroencephalographic findings in children with cerebral palsy: a study of 151 patients.

EEG abnormalities were studied in 151 patients (79 boys, 72 girls age range 0.4-13 years) with cerebral palsy (CP). They all had standardised EEG recordings, which were read by the same electroencephalographer. Eighty-one children had seizures and 70 were seizure-free. The EEG abnormalities in the seizure group included slow waves in 36 patients (generalised asynchronous in 33 and generalised synchronous in 3); amplitude abnormalities in 2 (focal in 1, generalised 1); epileptiform activity (including isolated sharp waves, isolated spikes, and spike-wave and polyspike-wave complexes) was seen in 66 (focal in 12; generalised in 48 and multifocal in 6). Hypsarrythmia was found in 4 and burst suppression in 1. Only 6 recordings were normal giving an overall percentage of abnormality of 92.6%. Of the CP patients without seizures, 28 (40%) showed generalised asynchronous slow waves; epileptiform activity was found in 27 (focal in 2, generalised in 23 and multifocal in 2); 3 subjects showed hypsarrythmia and 24 recordings were normal. The overall percentage of abnormality in this group was 76%. Cerebral palsy in children, regardless of its cause may be associated with generalised focal EEG abnormalities. This may reflect heterogeneity of the neural-generator in the underlying disease process.

Cerebral Palsy↗