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A Anania

Publications and source records attributed to A Anania.

24 records · Page 2Linked to original sources
PubMed1988

B lymphocyte markers in multiple myeloma and related plasma cell dyscrasias.

Multiple myeloma and benign monoclonal gammopathies are regarded as monoclonal B cell proliferations in which B lymphocyte maturation is blocked in the final stages of the differentiation cycle. "Blocked" cells accumulate in the body and produce large quantities of immunoglobulins. These are monoclonal, because they come from a monoclonal cell stock. This study presents the results of peripheral B lymphocyte and marrow plasma cell typing designed to reveal the postulated isotypical relationship of the proliferating cells and the serum paraprotein. A good, though not absolute correlation between the two immunoglobulins was noted in most patients. The data, however, was not used in the diagnosis and treatment of these diseases. Further studies with MoAb's will, perhaps, provide a finer subclassification of the B lymphocyte proliferation diseases and assist in their diagnosis and treatment.

Antibodies, Monoclonal↗
PubMed1978

[Sea-blue histiocytosis. Clinical and immunological study of a familial case].

This case (a young man) presented a clinical picture of a hard periorbital edema, hepatosplenomegaly and a mild bilateral pulmonary fibrosis. The histopatological pattern of our case (as well as his sister affected with the same syndrome) was characterized by the presence of macrophages full of blue staining granules and bone marrow macrophagic infiltrations. In the pulmonary function tests the volumes and compliance test and diffusing capacity were normal. The enzymatic deficit of the macrophage leads to the increase storage of phosphoglicerides and phosphosphingolipids responsibles for the blue staining with Wright-Giemsa stain. Our case fit into the specific pathology of the macrophage cell in accordance with the more recent views of the autonomy of the MPS (Mononuclear Phagocytic System). The known relationship between macrophages and T and B lymphocites have prompted us to study the cellular and humoral immunological behaviour of our case. We have observed an increased IgM immunoglobulins and an increase of IgM surface membrane receptors. Our results will be illustrated and compared with the until known 70 publicated cases.

Adult↗
PubMedDate not supplied

[Physiopathology and clinical aspects of monoclonal IgM gammopathy].

Ten subjects with IgM monoclonal gammopathy were studied with particular references to their clinical pictures. In 7 cases, the M component was W's macroglobulinaemia (MW) and in 3 undetermined monoclonal gammopathy (UMG). Serum IgM was always greater than 2170 mg% in MW and greater than 1120 mg% in UMG. All patients were over 45. Haemorrhage and autoimmune phenomena were noted in 2/10 cases, and liver and spleen enlargement in 7/10, peripheral lymphocytosis in 5/10, marrow lymphoplasmacytosis in 7/10, and plasma hyperviscosity in 7/10. Beta-2-microglobulin (beta-2MG) was higher on average in the 7MW cases than in the 3 UMG. A monoclonal peak was observed casually in 2/10 and after it had been clinically suspected in 3/10. ESR was high in all cases. The clinical and laboratory data are interpreted in the light of the possible pathogenetic mechanism. In addition, stress is laid on their importance in the differentiation of these two forms of IgM monoclonal gammopathy.

Aged↗