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Biomedical subjects

A Appels

Publications and source records attributed to A Appels.

At least 55 records · Page 3Linked to original sources

Cross-validation of the A/B typology in The Netherlands.

In a retrospective patient-control study in The Netherlands, relationships were established between the coronary-prone behavior pattern, as measured with the Structured Interview (SI) and the Jenkins Activity Survey (JAS), and selected Dutch questionnaires, i.e. The Maastricht Questionnaire (MQ) on vital exhaustion as a prodrome for myocardial infarction, the Western Time Attitude Scale (WTAS), and the Achievement Motivation Test (AMT), among others. The SI and the MQ discriminated best between patients (n = 58) and controls (n = 58); negative fear of failure (AMT subscale) was significantly associated with patients but not so with controls, as was time anxiety (WTAS subscale).

Adult↗

Psychological prodromata of myocardial infarction and sudden death.

In this prospective study a psychological test (the "Maastricht Questionnaire') was constructed which measures feelings of vital exhaustion and depression. It is shown that those subjects who have elevated scores on this test have more chance to get a new coronary event within a period of 10 months than those who have low scores on this test.

Death, Sudden↗

Behavioral risk factors of sudden cardiac arrest.

OBJECTIVE: The purpose of this study was to investigate the association between sudden cardiac arrest (SCA) and the behavioral factors exhaustion and nonexpression of emotions. METHODS: Case-control study of 99 victims of SCA and 119 coronary controls, matched for gender and age. RESULTS: Victims of SCA were more often assessed as exhausted and as closed by their family members than controls. A significant interaction between exhaustion and closeness on the risk of SCA was observed. Those who were exhausted and did not express their emotions had a sevenfold greater risk of SCA. CONCLUSION: The behavioral factor of exhaustion and nonexpression of emotions may contribute to the identification of persons at elevated risk for SCA.

Adult↗

Cardioprotective effect of moderate drinking: possible mediation by vital exhaustion.

A curvilinear relationship between alcohol consumption and heart disease risk has often been demonstrated. A similar relationship was found between vital exhaustion (VE) and alcohol intake in 62 Japanese and 53 British healthy males. Vital exhaustion is a prodromal state for cardiac events. A possible connection between moderate social drinking, VE and heart disease is suggested.

Alcohol Drinking↗

Relationship of blood coagulation and fibrinolysis to vital exhaustion.

OBJECTIVE: Acute physical and psychological stressors affect blood coagulation and fibrinolysis, but little is known about hemostatic factors associated with chronic psychological stress. Prolonged psychological stress may end in a state of vital exhaustion, which has been shown to be a risk factor for first myocardial infarction and recurrent events after coronary angioplasty. The present study tested the hypothesis that vital exhaustion resulting from chronic psychological stress is associated with impaired fibrinolytic capacity and increased coagulation factors. METHODS: On the basis of a validated questionnaire and subsequent structured interview, a well-defined group of otherwise healthy exhausted men was recruited (N = 15) and compared with age-matched not-exhausted controls (N = 15). Fibrinolytic measures included tissue plasminogen activator (TPA) antigen and plasminogen activator inhibitor (PAI-1) activity, and as coagulation factors we examined factors VIIc, factor VIIIc, and fibrinogen. Control variables were: blood pressure, smoking status, triglycerides, cholesterol, and standard hematological measures. Samples were collected twice to correct for intraindividual fluctuations. Statistical analyses were performed using 2 x 2 mixed model analysis of variance with subsequent univariate testing. RESULTS: Vital exhaustion was associated with significantly elevated levels of PAI-1 activity (p = .023). The higher PAI-1 activity in exhausted subjects (median = 13.0 U/ml vs. 6.0 U/ml) was not accounted for by smoking status or serum lipids. No significant differences were observed in TPA antigen, factor VIIc, factor VIIIc, and fibrinogen. The groups did not differ in blood pressure, smoking status, triglycerides, cholesterol, or standard hematological measures. CONCLUSION: These data suggest a reduced fibrinolytic capacity in exhausted individuals. Therefore, the relationship between vital exhaustion and risk of myocardial infarction may be mediated in part by an imbalance between blood coagulation and fibrinolysis.

Adult↗

Depressive symptomatology and vital exhaustion are differentially related to behavioral risk factors for coronary artery disease.

OBJECTIVE: This study proposes to assess the differences of two psychosocial risk indicators for coronary artery disease (CAD), ie, depressive symptoms and vital exhaustion. METHOD: In a representative, stratified, nation-wide sample of the population of Hungary over the age of 16 years (N = 12,640), analyses were made of whether those risk indicators were differentially related to several illness behaviors (including history of cardiovascular treatment and cardiovascular sick days), cognitions, mood states, and socioeconomic characteristics that may generally be associated with increased CAD risk. The sample was stratified by age, sex, and composition of the population of all counties in Hungary. RESULTS: Although depressive symptoms and vital exhaustion correlated strongly, there were clear and significant differences in strength of association between depressive symptoms, vital exhaustion and several variables under study. Dysfunctional cognitions, hostility, lack of purpose in life, low perceived self-efficacy, illegal drug use, alcohol and drug abuse, several forms of subjective disability complaints and history of treatment because of congenital disorders, and chronic skin and hematological disorders were more often associated with depressive symptoms, whereas loss of energy, use of stimulants, chest-pain-related disabilities, history of treatment because of cardiovascular disorders, and self-reported cardiovascular sick days were significantly more often associated with vital exhaustion. CONCLUSIONS: Vital exhaustion and depressive symptomatology are differentially associated with relevant external criteria. Vital exhaustion is associated with perceived cardiovascular complaints and history of cardiovascular treatment, whereas depressive symptomatology seems to be more closely connected to disabilities and complaints related to alcohol, drug, and congenital-disorder, and to dysfunctional cognitions and hostility.

Adolescent↗