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Biomedical subjects

A Arcasoy

Publications and source records attributed to A Arcasoy.

12 recordsLinked to original sources
PubMed1978

Ocular granulocytic sarcoma (chloroma) with acute myelomonocytic leukemia in Turkish children.

In a series of 166 leukemic children from Turkey, 56 had acute myelomonocytic leukemia (AMML). Seventeen boys and 3 girls presented with chloroma-like deposits (granulocytic or myeloid sarcomas) in the eye and orbit, all showing AMML on initial study of blood and marrow. The ocular lesions responded rapidly to antileukemic therapy. Laboratory studies of AMML cases revealed no cytogenetic or immune defects, and Epstein-Barr virus titers were normal. A group-specific (GS-3) antigen (type-C virus?) was identified in one patient by radioimmunoassay of orbital tumor extracts. It is not clear what factors contribute toward the myelomoncytic differentiation of leukemia and its localization in the eye and orbit, but opportunities for further study are enhanced by reports of a predisposition to ocular chloroma among leukemic children in Africa, Egypt, and Japan.

Adolescent↗
PubMed1978

Hair zinc levels in healthy and malnourished children.

In this study the hair zinc levels of 115 healthy subjects, 50 girls and 65 boys, between the age groups 0 to 15 years were determined by using atomic absorption spectrophotometry. The hair zinc levels obtained generally agree with those reported in the literature. The hair zinc levels of the subjects were studied as a function of age, sex and color of hair. It was found that the levels of hair zinc increased as a function of age, whereas no statistically significant differences with respect to sex and color of hair were observed. In a protein-calorie malnourished group of 11 girls and six boys between the ages 0 to 3 years, it was found that the hair zinc levels were significantly higher than a group of healthy subjects of the same age range. In a protein-calorie malnourished group of seven subjects no correlation was found between hair zinc and serum levels.

Adolescent↗
PubMed1978

Decreased iron and zinc absorption in Turkish children with iron deficiency and geophagia.

Oral iron and zinc tolerance tests were performed in 12 patients between 8 and 21 years of age, with iron deficiency anemia and geophagia. Decreased iron and zinc absorption were detected respectively in patients against the elevated absorption curves in control subjects. Iron and zinc malabsorption may be an additional feature of the syndrome characterized by geophagia, iron deficiency anemia, hepatosplenomegaly, hypogonadism and dwarfism observed in Turkey and Iran.

Adolescent↗
PubMed1978

Ultrastructural studies on AMML and ocular granulocytic sarcoma.

The ultrastructural analysis of the leukemic cells in twelve cases with AMML was considered a valuable tool in the diagnosis of this type of leukemia. Furthermore intracytoplasmic structure resembling virus like particles were observed in three bone marrow and one eye sample of the patients studied. The role of C-type RNA viruses in the etiology of leukemia was discussed.

Bone Marrow↗
PubMed1977

Serum zinc levels, lymphocyte counts and functions in pediatric Hodgkin's disease.

Serum zinc levels, total lymphocyte counts, cutaneous reactivity to three intradermal antigens and the in vitro lymphoblastic transformation response to PHA were evaluated in 24 children with Hodgkin's disease and 20 control cases. Serum zinc level was measured by atomic absorption spectrophotometer (Perkin Elmer M 103) in Hodgkin's cases and found to be significantly decreased in the whole group of patients and reached the lowest level in LD type and the IVth stage of disease. The overall response to PHA was reduced in Hodgkin's cases. It was significantly low in the group of LD subtype. Delayed cutaneous hypersensitivity reactions were also markedly decreased in the IV stage and MC, LP subtypes of Hodgkin's patients. Our preliminary results disclosed a relationship between serum zinc level and the lymphocyte abnormalities in Hodgkin's disease.

Adolescent↗
PubMed1977

Hodgkin's disease in Turkish children: a clinical and histopathologic analysis.

Fifty-one cases of Hodgkin's disease in Turkish children under 15 years of age were clinically analyzed, and 40 cases were evaluated histopathologically according to the Rye Conference classification. Complete clinical, laboratory, and radiologic findings for each patient were examined. Most patients were of low socioeconomic class, and nearly all were Caucasian. The most common presenting clinical sign was cervical lymph node enlargement; hepatosplenomegaly was noted in 18 patients. Nearly three times as many males as females were found among the patients whose diseases were histologically analyzed, and most of the children with Hodgkin's disease were in the first decade of life. Classification of the cases revealed a predominance (67.5%) of the mixed cellularity (MC) type. Of 40 patients analyzed, 34 had disease in clinical stage IV, mostly of the MC type. The data indicated a correlation of the high incidence of the MC type of Hodgkin's disease with the socioeconomic and environmental conditions in Turkey.

Adolescent↗
PubMed1976

Haemoglobin LeporeBoston in a Turkish family.

Haemoglobin Lepore was demonstrated in four members of a Turkish family. It was found in the heterozygote state and was associated with erythrocyte morphology similar to that observed in the beta thalassaemia trait. The average concentration of haemoglobin Lepore was 8.1% of the total haemoglobin. Structural analysis showed that the Lepore haemoglobin was the LeporeBoston type. This is the first reported instance of the occurrence of haemoglobin Lepore in Turkey.

Child↗
PubMed1975

Changes of trace minerals (serum iron, zinc, copper and magnesium) in thalassemia.

We have determined serum Zn, Fe, Cu and Mg in 42 patients aging from 3 months to 22 years with homozygous beta-thalassemia and thalassemia intermedia and in 36 control subjects of the same ages. Serum zinc was significantly decreased. Serum copper and iron were increased, but magnesium was found to be at normal levels.

Adolescent↗