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Biomedical subjects

A Arije

Publications and source records attributed to A Arije.

21 records · Page 2Linked to original sources

Temporal variations and meteorological factors in hospital admissions of chronic renal failure in south west Nigeria.

A study of hospital admissions of chronic renal failure cases during the 5 years 1987-1991 in a major referral centre in South West African showed a significant departure from a uniform monthly distribution (P < 0.01). Admission rates were high in February-March and June-August showing 2 peaks. There was no absolute seasonal effect. Mean monthly admissions did not differ between the dry (9.7 +/- 0.6 SE) and wet (9.8 +/- 0.6 SE) seasons. Possible reasons for the variations are discussed. For health planning, high admission rates can be anticipated and resources mobilized to meet the increased demands at these periods when they occur.

Humans↗

The viability of hemodialysis as a treatment option for renal failure in a developing economy.

The viability of hemodialysis as a treatment option for renal failure in a developing economy like Nigeria was assessed in this study to determine whether committing huge capital in establishing such centres all over the country is justifiable. A total of 158 patients dialysed at the Owena Dialysis Centre over a period of 3 years (January 1991-December 1993) were studied. There were 112 males and 46 females, ranging in age between 15 and 81 years. 17 of patients had acute renal failure (ARF), while 141 had chronic renal failure (CRF). During the period of study, a total of 1,452 dialysis sessions were carried out ranging between 8 and 77 sessions per month (mean 40 sessions/month). Dialysis sessions ranged between 1 and 101 sessions per patient. A progressive increase in the number of dialysis sessions between 1991 and 1993 was noted, and new patients who required dialysis were being seen at a rate of between 1 and 10 per month. 112 patients (70.8%) could afford dialysis for less than one month while only 3 (1.9%) could afford to continue dialysis for over 12 months. All cases of ARF (except one) recovered normal renal function after dialysis, while 116 CRF patients were discharged home after less than 10 sessions of dialysis due to financial constraints. The study shows that hemodialysis is a relevant treatment option for renal failure even in a developing economy like Nigeria subject to adequate health planning. The major limitations to its profitable utilization under the present health care dispensations are highlighted.

Acute Kidney Injury↗

Oral slow-release nifedipine in the rapid treatment of severe hypertension in Nigerians.

The effect of the oral slow-release formulation of Nifedipine in rapidly lowering blood pressure was studied in 20 severely hypertensive Nigerians (8 males, 12 females). A significant fall (p < 0.05) in mean systolic, diatolic, and mean arterial pressure was obtained 30 minutes after administration of Nifedipine. The fall in all three parameters of blood pressure remained sustained and significant (p < 0.05) 6 hours after a single dose administration. Side effects were minimal and limited to headaches in 20% of patients and palpitations in 10%. All patients showed a sustained control of blood pressure over a three month follow up period on slow release Nifedipine. Addition of methyldopa resulted in improved blood pressure control in one patient with chronic renal failure. It was concluded that oral slow release Nifedipine is a drug of choice in the rapid and sustained control of blood pressure in severely hypertensive patients especially in a setting where critical intensive monitoring facilities are limited.

Administration, Oral↗