Biomedical subjects

A Aslan

Publications and source records attributed to A Aslan.

At least 37 records · Page 2Linked to original sources

PubMed2000

A radiologico-anatomical comparative study of the cochlear aqueduct.

AIM: A comparative radiologico-anatomical study of the cochlear aqueduct (CA) was performed. MATERIALS AND METHODS: Eight cadavers and 23 dry temporal bones were studied. High-resolution computed tomography (HRCT) was carried out on each cadaver before microdissection. Microdissection was carried out in a plane parallel to the HRCT sections. RESULTS: The CA was found to be located an average of 7 mm inferior to the internal acoustic meatus and at the superior edge of the jugular foramen. The external aperture of the CA was triangular in shape in 18 bones (78.3%). The petrosal fossa was located just inferior to the external aperture and housed the glossopharyngeal nerve, which had an incomplete bony canal in four bones (17.4%) and a complete bony canal in three bones (13%). It was possible to demonstrate the petrosal portion of the CA on both coronal and axial HRCT. The otic capsule segment of the CA was impossible to demonstrate on coronal sections. CONCLUSION: The CA cannot be visualized in only one section of the plane in HRCT. Both the otic capsule and petrosal segments can be demonstrated on axial HRCT.

Aged↗

PubMed2000

Chondrosarcoma of the nasal septum.

Chondrosarcoma of the nasal septum is a rather uncommon tumour. Therefore, only limited numbers of cases have been described in the literature. This paper reveals one more case observed at the ORL department of Dicle University. In the present case, by using a transnasal and transpalatal approach, total resection of the tumour was performed in conjunction with postoperative radiotherapy.

Adult↗

PubMed1999

Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography.

In this research, several royal jellies and commercial products containing royal jelly were analysed for their trans-10-hydroxy-2-decenoic acid (10-HDA) content by using a column liquid chromatography technique. Ten samples claimed to be pure royal jelly, containing 10-HDA between 0.75 and 2.54%. Seven samples claimed to contain royal jelly as an ingredient which ranged from non-detectable to 0.054%. The technique was found to be rapid with high recovery.

Animals↗

PubMed1999

An uncommon association relating to cloacal maldevelopment: bladder agenesis, anorectal atresia, and absence of vulva, vagina, and uterus.

The authors report on a newborn girl with complex urogenital and hindgut abnormalities. Urogenital anomalies consisted of absence of vulva and vagina, uterine and urethral atresias, bladder agenesis with ectopic ureteric opening, and bilateral pelvic ectopic kidneys. In addition, the baby had anorectal atresia without fistula as a hindgut anomaly. Herein, clinical evaluation and embryological review are made to explain the concomitant occurrence of these rare malformations.

Abnormalities, Multiple↗

PubMed1999

Surgical exposure in translabyrinthine approaches--an anatomical study.

OBJECTIVE: Translabyrinthine approach (TLA) is a procedure of choice for the removal of vestibular schwannomas in cases of profound hearing loss. There is a lack of anatomic studies reviewing the surgical anatomy of the cerebellopontine angle (CPA) as seen in the classical and enlarged TLAs. METHODS: Seven formalin-preserved cadavers were dissected. Structures, visualized in the CPA through the TLA, were scored according to the degree of their exposure (1, structure not seen; 2, partial exposure; 3, full exposure). RESULTS: The acousticofacial bundle, anterior inferior cerebellar artery and flocculus had the highest scores in both types of surgery. However. the fifth, ninth, and tenth cranial nerves, prepontine cistern, pons, superior cerebellar artery, and posterior inferior cerebellar artery had higher scores, i.e. better exposure, in the enlarged TLA than in the classical TLA. CONCLUSION: These findings suggest that the enlarged TLA be preferred in cases of larger tumors extending to either jugular foramen or middle fossa whereas the indications of the classical TLA should be limited to vestibular neurectomy and removal of smaller tumors.

Brain Mapping↗

PubMed1999

The subarcuate canaliculus and its artery--a radioanatomical study.

The anatomy of the subarcuate canaliculus (SAC), subarcuate fossa (SAF) and subarcuate artery (SAA) was studied in 12 cadavers and 35 dry temporal bones. Each cadaver was scanned with high resolution CT (HRCT) prior to microdissection. The SAC was always found to be a single canal located between the two arcs of the anterior semicircular canal in both microdissections and HRCT scans and the internal acoustic meatus was observed to be located just inferior to the SAC. The SAC was on average of 9.2 mm in length and 1 mm in width. The SAF was situated at a distance of 4.2 mm from the internal acoustic meatus, 3.5 mm from the groove for the superior petrosal sinus, 6.7 mm from the opening of the vestibular canaliculus and 11.5 mm from the most superior part of the jugular foramen. The SAA was found to originate from the anterior inferior cerebellar artery in 9 cadavers and from the internal auditory artery in 3 cadavers. The SAA always emerged from the main artery outside the internal acoustic meatus. It ran through the SAC as a single artery. This study investigated CT correlated anatomical aspects of the subarcuate canaliculus and its artery which is claimed to be responsible for the blood supply of the mastoid antrum, facial canal and bony labyrinth.

Cadaver↗

PubMed1999

Prophylactic ranitidine in experimental fetal distress: acute phase effects on the fetal stomach.

Fetal distress (FD) adversely affects fetal gastric physiology and histology, increasing gastric acid secretion and disturbing gastric protective mechanism. Considering these findings, an experimental study was planned to test whether ranitidine prevents FD-related gastric physiological and histological changes during late gestational period. In this study, a rabbit model of FD was created by way of intermittent maternal aortic occlusion. In group 1 (SC), saline treated animals underwent control operation. In group 2 (SD), FD was created in saline treated animals. In group 3 (RC), ranitidine treated animals underwent control operation. In group 4 (RD), FD was created in ranitidine treated animals. Blood lactic acid levels of the fetuses were 2.3 +/- 1.0 mg/L in SC group and 4.7 +/- 1.8 mg/L in group SD (p < 0.01); 2.5 +/- 0.9 mg/L in group RC and 6.7 +/- 2.5 mg/L in group RD (p < 0.01). Fetal gastric acid secretion was 5.94 +/- 2.13 microEq/h in group SC and 8.26 +/- 2.24 microEq/h in group SD (p < 0.05); 6.63 +/- 2.3 microEq/h in group RC and 6.04 +/- 2.43 microEq/h in group RD (p < 0.05). Fetal gastric PGE2 level was 16.4 +/- 2.65 microg/g-wet weight in group SC and 7.62 +/- 1.86 microg/g-wet weight in group SD (p < 0.01); 15.6 +/- 2.61 microg/g-wet weight in group RC and 8.44 +/- 1.44 microg/g-wet weight in group RD (p < 0.01). In addition, histopathological examination showed normal gastric structure in groups SC and RC, but there were mild erosive and hemorrhagic changes in groups SD and RD. Because prophylactic ranitidine significantly decreased gastric acid secretion, but did not prevent harmful histopathologic effects in FD, it is suggested that gastric damage cannot be avoided by decreasing gastric acid secretion alone. However PGE2 analogs with or without H2 receptor blockers may have a potential role to prevent FD-related gastric damage.

Animals↗

PubMed1999

Congenital non-familial unilateral basaloid follicular hamartoma.

Basaloid follicular hamartoma is not a well-recognized clinical entity and has often been diagnosed as trichoepithelioma or basal cell carcinoma. It is a unique benign follicular tumour which comprises a variety of clinical manifestations. We present the case of a 24-year-old male with unilateral basaloid follicular hamartoma present at birth and later misdiagnosed as basal cell carcinoma. Histological features of basaloid follicular hamartoma are not always diagnostic and clinico-pathological correlation is particularly important to distinguish this benign hamartoma from other basaloid tumours including basal cell carcinoma. Continuous follow-up of our patient did not reveal any clinical or histological malignant transformation.

Adult↗

PubMed1998

Anatomic relationships between surgical landmarks in type b and type c infratemporal fossa approaches.

Anatomic relationships of the structures exposed in type B and C infratemporal fossa approaches were studied in 20 temporal bones. The intrapetrous carotid artery (ICA), cochlea (CH), eustachian tube (ET), foramen spinosum (FS), foramen ovale (FO) and anterior foramen lacerum (AFL) were exposed by drilling of the glenoid fossa and base of middle cranial fossa. The relationships of the ICA with the cochleariform process (CP), CH, ET, FS, FO and AFL were noted along with associated measurements. The CP was lodged at a mean distance of 9.2 mm from the ICA genu. The ET was found to intersect the ICA. The mean distance of the ICA to the CH was 1.6 mm. The carotid canal was dehiscent on its horizontal portion in 30% of the bones studied and on its vertical portion in 5%. The periarterial venous plexus was found in 70% of the bones. No obvious branch was observed emerging from the vertical portion of the ICA. The FS was found to be a canal having a mean length of 5.8 mm.

Adult↗

PubMed1998

The jugular foramen: a comparative radioanatomic study.

BACKGROUND: Advances in microsurgical techniques made possible the removal of advanced jugular foramen (JF) lesions, which once had been accepted as unoperable. However, successful surgery requires detailed knowledge of the JF anatomy. METHODS: Sixteen jugular foramina in eight formalin-preserved adult cadavers were scanned with axial and coronal high resolution computed tomography (HRCT) prior to dissection. After craniectomy and removal of brain tissue, the relationships of the neurovascular structures in the JF were determined by drilling the temporal bones from superior to inferior on planes parallel to the skull base. RESULTS: No bony partition of the JF was observed. A dural band consistently divided the JF into two parts. Anterior to it was the glossopharyngeal nerve (IX) while the vagus (X) and accessory (XI) nerves were located posteriorly. There was a notch in which the IX nerve entered the JF. It was also identified on the CT scans and defined as the glossopharyngeal recess. The IX nerve made a genu within the JF in all specimens. Then, it ran inferiorly through a bony canal in three specimens (18.75%), and through an incomplete bony canal in two (12.5%), which were also defined on the CT images. The inferior petrosal sinus ran through a sulcus anteromedial to the glossopharyngeal recess. The posterior meningeal artery was found to be located between the X and XI nerves within the JF. CONCLUSIONS: This study revealed a complex and highly variable pattern of the relationships of the neurovascular structures in the JF, and their HRCT images correlated well with the anatomic microdissections.

Aged↗

PubMed1998

Sucralfate for posttonsillectomy analgesia.

Pain is one of the most troublesome complications of tonsillectomy. The pain appears as throat pain, otalgia, or both, and continues until mucosal recovery on the tonsillar fossae is complete. Some surgical and hemostasis techniques may increase pain. Analgesics, antibiotics, steroids, and local and topical anesthetics are used to relieve posttonsillectomy pain, but none has the desired effectiveness. The pain reliever must not increase bleeding and must have minimal side effects. Sucralfate, a basic amino salt of sucrose octasulfate, binds to the matrix protein of a peptic ulcer and produces a protective barrier. Tonsillectomy leaves two large ulcerous wounds, and sucralfate may bind those wounds as it does peptic ulcers. In this controlled study, the efficacy of sucralfate on posttonsillectomy throat pain, otalgia, analgesic requirement, degree of strength, bleeding, body temperature, and mucosal recovery is investigated in 80 patients. Sucralfate is found to significantly reduce throat pain and analgesic requirement after surgery.

Adolescent↗

PubMed1998

A new dosage regimen for topical application of ciprofloxacin in the management of chronic suppurative otitis media.

The clinical and bacteriologic efficacy of topically applied ciprofloxacin was studied in 60 patients with chronic suppurative otitis media. Two hundred fifty and 125 microg/ml concentrations of ciprofloxacin solutions were given to two groups of patients. The duration of therapy was determined according to the clinical cure at follow-up. More than 21 days of therapy was not needed in any patient. The clinical cure rate with 250 microg/ml ciprofloxacin was 78.1% at 14 days and with 125 microg/ml it was 83.3%. However, a 100% clinical cure rate and complete bacteriologic eradication was obtained in 21 days in both groups. In each group only one patient had otomycosis by the fourteenth day of therapy, although ear discharge had ceased. It was concluded that 125 microg/ml ciprofloxacin could be applied as successfully as 250 microg/ml, and the duration of therapy had to be at least 14 days. This new dosage regimen can be adopted as an optimal dosage for ototopical application of ciprofloxacin in chronic suppurative otitis media. It will also obviously decrease the expense of therapy.

Administration, Topical↗

PubMed1998

Titration streptomycin therapy in Meniere's disease: long-term results.

As soon as the use of streptomycin was started for the treatment of tuberculosis, its ototoxic effect was discovered. Initial reports demonstrated that streptomycin was successful in reducing vestibular responses while preserving cochlear activity. Streptomycin sulfate has been used for almost half a century for the treatment of vertigo in patients with Meniere's disease. At the Gruppo Otologico, Piacenza, Italy, between 1987 and 1995 we treated 16 patients with either bilateral Meniere's disease or with Meniere's disease in their only hearing ear, adopting the titration streptomycin therapy protocol of Graham et al. Three patients with follow-up periods of less than 2 years were not included in this study. The ages of the patients ranged from 36 to 64 years with a mean of 49.2 years. The patients were observed for 2 to 8.8 years. The dose of administered streptomycin varied from 14 to 49 gm. Episodic vertigo was totally relieved in all of the patients after initial treatment, whereas hearing remained the same or was improved when compared with the pretreatment levels. Five of the patients experienced recurring vertigo during a period of 4 to 24 months after initial treatment. Oscillopsia persisted in two patients and ataxia in darkness persisted in another two patients. Hearing was unchanged in 14 ears, improved in 2 ears, and worsened in 4 ears at the last follow-up evaluation. The overall outcome indicated that intramuscular titration streptomycin therapy seems to be one of the most important therapeutic options in the treatment of disabling vertigo in patients with either bilateral Meniere's disease or Meniere's disease in an only hearing ear.

Adult↗

PubMed1998

Facial nerve paralysis in chronic suppurative otitis media: Ankara Numune Hospital experience.

Although the incidence of facial nerve paralysis (FNP) decreased with the use of contemporary diagnostic tools and the advent of antibiotics, it is still a challenging problem. In this retrospective study, the charts of 1188 patients with chronic suppurative otitis media (CSOM), treated between 1988 and 1996 in the First ENT Clinic of Ankara Numune Hospital, Turkey, were analysed to establish the pre-operative incidence of FNP in CSOM. There were 20 (1.7%) patients with FNP secondary to CSOM. Of these, 14 (70%) had cholesteatoma. There was a defect on the fallopian canal in 14 patients (70%) and it was most commonly located on the tympanic segment of the canal (35.7%). Paralysis was incomplete in all patients. A total of 14 patients had ear drainage more than 3 years. FNP was associated with vertigo in three patients (15%) and tinnitus in one patient (5%).

Adult↗

PubMed1998

An anatomical study of the tympanic branch of the glossopharyngeal nerve (nerve of Jacobson).

Our study was aimed to examine the anatomic relationships of the tympanic branch of the glossopharyngeal nerve (GPN), namely the Jacobson's nerve (JN). The JN is the first branch of the GPN after having passed the jugular foramen. It contributes to the tympanic plexus on the promontory. It transmits secretory innervation to the parotid gland. Its possible role in the regulation of the middle ear pressure has also been hypothesized in terms of animal studies. Using microdissection techniques and high-resolution computed tomography (HRCT) scanning, the anatomic relationships and course of the JN were examined in eight formalin-preserved cadavers (16 sides). A morphometric analysis related to the JN was also performed both in the 16 cadavers and 40 dry-skull specimens. The JN emerged from the inferior ganglion of the GPN in all specimens. The mean distance between the ganglion and the genu of the GPN was 11.3 mm. The inferior 2/3 of the tympanic canal (TC) followed a vertical course, and then it ran anteromedially with an angle of 160 degrees to 170 degrees. The mean length of the TC was 9.5 mm. The TC was well-defined in all axial HRCT scans. In 2 cases the JN was entirely encased in a bony canal in the middle ear. A double JN was observed in one case. This study gives an additional information regarding the anatomy of the JN.

Aged↗

PubMed1998

A gastroschisis-like abdominal wall defect in the left hypochondrium. Case report and literature review.

Congenital abdominal wall defects are exceedingly rare on the left side. The presented patient had an upper abdominal wall defect located just lateral to the left rectus muscle. Additionally, upper parts of the abdominal flat muscles were defective on that side. Because no report was found in the literature about the defect described here, both its terminological and embryological backgrounds are discussed.

Abdominal Muscles↗

PubMed1998

The cochlear aqueduct: an important landmark in lateral skull base surgery.

The cochlear aqueduct (CA) is used as a landmark in lateral skull base surgery. In this study anatomic relationships between the CA and adjacent neurovascular structures were examined by dissecting 32 temporal bones. Observations of the relationship of the external opening (EO) of the CA with the ninth, tenth, and eleventh cranial nerves, inferior petrosal sinus (IPS), and intrapetrous carotid artery (ICA) were noted. In addition to the distance of the EO of the CA to the vertical portion of the ICA, the entire length of the CA and the width of the EO were also measured. The ninth nerve was the only structure lodged at the EO of the CA in 34.4% of bones. However, in 40.6% of bones only the IPS crossed the EO of the CA, although the ninth nerve was situated just anteroinferiorly in the vicinity of the EO. In 15.6% of bones it was possible to observe both the ninth nerve and the IPS crossing the EO. In 9.4% of bones the EO of the CA was found to be occupied by the tenth and eleventh nerves. It was also observed that the ICA was located anteriorly on the same sagittal plane with the EO in 15.6% of bones. It was concluded that although in 90% of cases the EO of the CA was in close relation with the ninth nerve, other structures such as the IPS, the tenth and eleventh cranial nerves, and the ICA were also at risk during drilling in this area because of their intimate relationships with the EO of the CA.

Adult↗

PubMed1998

A clinico-anatomic study of the auricular branch of the vagus nerve and Arnold's ear-cough reflex.

The results of a clinico-anatomic study of the auricular branch of the vagus nerve (ABVN) and Arnold's ear-cough reflex are presented. The frequency of the ear-cough reflex was found to be 2.3% (12 out of 514 patients). It was bilateral in 3 cases (0.6%). The reflex was elicited by palpation of the postero-inferior wall of the external acoustic meatus (EAM) in 11 patients, and by palpation of the antero-inferior wall in one patient (0.2%). The reflex was frequently noticed to occur after a short latent period. The course of the ABVN inside the jugular foramen (JF), and distribution of the terminal branches of the ABVN in the external acoustic meatus were determined in 8 male cadavers (16 sides). In addition, the length of the mastoid canaliculus (MC) and the relationships of the ABVN with the facial nerve and stylomastoid foramen (SMF) were studied in both cadavers and 25 dry skulls (50 sides). High-resolution computed tomography (HRCT) scanning was also performed in all cadavers prior to microdissections. The ABVN emerged from the superior ganglion of the vagus nerve in all the cadavers. It ran between the internal jugular vein (IJV) and the bony wall of the jugular foramen. The ABVN was encased in a partial bony canal during its course from the jugular foramen to mastoid canaliculus in 18% of all specimens. The average length of the mastoid canaliculus was 5.6 mm (4.2-6.5), and it ran transversely towards the tympanomastoid suture 4.5 mm (4-5.1) above the stylomastoid foramen. The mastoid canaliculus was well demonstrated in all the HRCT scans.

Adult↗