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Biomedical subjects

A Audebert

Publications and source records attributed to A Audebert.

At least 37 records · Page 2Linked to original sources
PubMed1990

[LUF-syndrome: recent findings].

Luteinization of a follicle without its rupture and without the oocyte being expelled which is also called the LUF-syndrome by English speaking authors is one of a number of functional abnormalities that can occur to the follicle in the ovary and is diagnosed by ultrasound methods. It is one that has been known for quite a long time. Many publications have appeared since 1978 to describe this syndrome, which all the same is still very controversial. One has learnt how to diagnose it fairly well. One knows more about its physiopathogenesis and how often it occurs. This seems to be more often when there is pelvic endometriosis or so-called unexplained infertility. What is more difficult however is to find out how important it is as a cause of lowered fertility, and it is also difficult to decide whether: it just happens occasionally or is a true syndrome? It is still not possible today to give a definite answer to this question because of reasons of methodology. Finally, as far as treatment goes, even if the facts about its pathogeneiity have been found out and should be able to help decide on a logical treatment there have been no controlled studies to find out whether the treatment works.

Female↗
PubMed1987

[The combination of epirubicin, bleomycin, vinblastine and prednisone (EBVP) before radiotherapy in localized stages of Hodgkin's disease. Phase II trials].

A new regimen of chemotherapy was used to reduce toxicity of ABVD: adriamycin is replaced by epirubicin and dacarbazine by prednisone. Thirty eight patients with Hodgkin's disease, stage I to IIIA, previously untreated, received three courses of this regimen before radical radiotherapy. Gastro-intestinal toxicity and alopecia appeared less marked than with ABVD. Immediate efficacy is similar with 80% of complete remission (one third observed at day 28) and only 2 failures. This regimen appears thus as a clear improvement in the treatment of patients with Hodgkin's disease and deserves larger comparison with previously used chemotherapy in a more extensive controlled trial.

Adolescent↗
PubMed1986

[Anemia in the elderly subject secondary to jejunal vascular malformation. Apropos of 2 cases].

Two cases of normocytic regenerative anemia in two patients aged 84 and 86 respectively were related to gastrointestinal bleeding. Abdominal angiography was negative in both cases. Only laparotomy provided a diagnosis of jejunal vascular malformation with the aid of peroperative endoscopy. Angiodysplasia was diagnosed in one case and capillary hemangioma in the other. In these very old people with very somber prognosis, anemia was corrected by surgery without recurrence after 8 and 10 months respectively. Gastrointestinal malformations are found in about 20 p. 100 of unexplained digestive hemorrhages. In most cases they are localized in the right large bowel, especially in old patients. Jejunal localizations are 7 to 8 times less frequent and have been described in younger patients. Up to now, selective abdominal angiography has been the main diagnostic procedure. We must insist on the value of peroperative endoscopy when angiography is negative.

Aged↗
PubMed1986

[Data collection from patients treated for Hodgkin's disease. Relation to quality of life].

One hundred and fifty patients treated for Hodgkin's disease (stage I to IIIA) in a cooperative trial, answered a questionnaire dealing partly with their information, after 2 to 7 years of complete remission. This information appears insufficient for the majority of patients (52%), at least as far as treatment and its complications are concerned. There are many significant relations with other parameters which suggest that a good level of information may improve quality of life of patients. These observations tend to increase information of patients with Hodgkin's disease, provided it is adapted to each patient.

Follow-Up Studies↗
PubMed1986

[Psychosocial repercussions of the the treatment of Hodgkin's disease. Assessment by questionnaire with 150 patients].

One hundred and fifty patients, treated for Hodgkin's disease (stages I-IIIA) in a cooperative trial and remaining in complete remission after 2 to 7 years, answered a questionnaire dealing with psychosocial status and quality of life. Many informations were gathered and studied by multiparametric methods. Quality of life of patients appears determined by three kinds of parameters: patients' characteristics (age, sex, family and work status); stage of the disease determining the intensity and duration of treatment; practical conditions of treatment. These last parameters may be improved by therapeutic team and all care-takers to decrease bad consequences of disease and treatment and also to increase quality of life after cure.

Adolescent↗
PubMed1985

Extended versus involved fields irradiation combined with MOPP chemotherapy in early clinical stages of Hodgkin's disease.

From 1976 to 1981, 335 patients with untreated Hodgkin's disease, clinical stages I, II, and IIIA, have been treated by MOPP (nitrogen mustard, vincristine, procarbazine, prednisone) chemotherapy, three to six cycles according to the prognostic factors, combined with radiotherapy. Irradiation was always performed after the first three cycles of chemotherapy, and was randomized between extensive radiotherapy, ie, mantle and paraaortic areas for supradiaphragmatic presentations, and radiotherapy restricted to the involved areas. No significant difference was observed between the two randomized branches for the disease-free survival (86% after six years in the involved field branch v 90% in the extended field branch), and none for the overall survival. Most of the relapses occurred in nonirradiated areas in the first group, and in irradiated areas in the second. Relapses were especially frequent in the IIE stages with pulmonary extension; extranodal relapses occurred with osseous and cutaneous localizations. Two cases of secondary leukemia were observed after three- or six-cycle MOPP plus radiotherapy limited to the involved areas.

Adolescent↗
PubMed1982

[Cytological complications of IUDs ].

The cytological modifications due to IUDs are incompletely or inaccurately known to clinicians and cytologists. IUDs of all types bring about a modification of the maturation index, and particularly of the estrogenic index which, throughout the cycle, appears to be lower than that of a control group. The presence of a sub-normal inflammatory contest in smears of IUD users is no proof of an increased incidence of microbic infections. Presently there is no sign of any carcinogenic role played by IUDs. The papillary metaplasia induced by IUDs appeared more frequently than squamous endometrial metaplasia.

Adult↗
PubMed1982

[Echography in gonadal dysgenesis and ovarian dystrophy (author's transl)].

Pelvic ultrasound examination was performed in 28 patients presenting with disorder in the onset of puberty (13 suggesting gonadal dysgenesis and 15, ovarian hyperandrogenism). Results of this investigation were compared with those of coelioscopy, in order to establish the respective value of each technique in the diagnosis of disorders of puberty in girls. In patients with gonadal dysgenesis, echography may show 'residual gonads but coelioscopy remains necessary when results of radiologic investigation are negative, when clinical or hormonal data suggest that ovarian function is present. Ultrasound examination showed one or two enlarged ovaries in all but one patients in whom coelioscopy had shown this abnormality. Pelvic echography is now the first test to be performed in girls with disorders of puberty as it often permits to avoid coelioscopy.

Adolescent↗
PubMed1981

[Artificial insemination donor and female fertility (author's transl)].

The authors have reviewed 140 cases of AID using frozen sperm in fine straws. With a follow-up of one year from the date the last couple was brought into the survey, the crude percentage for conception is 65 and can reach up to 73.3% with a mean rate of conception per cycle of 10% in couples who carry on for a minimum of six cycles. The ability of the sperm to fertilise seems comparable whether they come from one or other of two centres for the study and storage of human sperm. The level for conception is less affected by features such as whether the sperm is fresh or frozen, or the number of spermatozoa that have been inseminated, than by the patient's age and also her fertility, in which also psycho-emotional factors have to be taken into account, but these are difficult to qualify. When the causes of lowered female fertility are able to be pinpointed and are curable, the hope for a successful pregnancy from AID should approach that found in so-called normal patients.

Abortion, Spontaneous↗