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Biomedical subjects

A Azzolini

Publications and source records attributed to A Azzolini.

At least 19 recordsLinked to original sources
PubMed1993

Localized hair follicle hamartoma.

A 4-year-old male presented with an indurated papular plaque on his right nasolabial fold. The lesion, present since the child was a few months of age, progressively extended in a band-like fashion up to the upper lip. Microscopically, there was almost complete replacement of the hair follicles by trichoepithelioma-like epithelial proliferations associated with hyperplastic sebaceous glands. We interpret this lesion as a localized form of the clinicopathological entity known as generalized hair follicle hamartoma.

Cell Division↗
PubMed1992

[A rare case of breast ectopy associated with partial agenesis of osteo-muscular structures of the thoracic wall. Proposal of an original reparative technique].

The Authors report a case of chest wall malformation characterized by costal defect (6th and 7th ribs), hypoplasia of the serratus and pectoralis major muscles, left mammary ectopy and mucoviscidosis. The case is reported because of the very singular malformative association and the originality of the reparative procedure. Appearance has been improved and a good shape and breast projection achieved.

Adolescent↗
PubMed1992

Long-term histopathologic evaluation of human expanded skin.

Forty-two patients operated on by skin expansion have been contacted after a mean time of 25 months from the last surgery. Two biopsies have been taken from the expanded area of each patient. In 12 patients it has been possible to obtain a similar sampling from the opposite, nonexpanded area of the body. The samples underwent optic microscopy and cell kinetic and DNA content investigations. The epidermal structure of the followed-up skin, compared with the skin of the opposite side of the body, looks normal. The mitotic activity of the epidermal cells has returned to the values of preexpanded skin. The dermis shows a low degree of elastosis and zonal fragmentation of elastic fibers. The hypodermis, where the expander capsule was removed during the last surgery, does not show an accentuated fibrosis.

Adolescent↗
PubMed1992

Skin expansion in head and neck reconstructive surgery.

We used a tissue-expansion technique to achieve soft-tissue reconstruction in congenital and acquired defects of head and neck. One hundred and fifty-five head and neck reconstructions have been performed, with a 6 percent rate of major complications. We present our planning and surgical approach for single areas. From a technical point of view, the only major difference from the rest of literature is the approach to the problem of periprosthetic capsule. In fact, we believe that complete removal of the capsule, which can be achieved without vascular risk thanks to a special technique, is necessary to obtain the best results.

Adult↗
PubMed1991

Cell kinetics and DNA content (ploidy) of human skin under expansion.

One question which still remains unanswered concerning expansion of human skin is whether expansion simply stretches the skin or whether it induces a real neo-production of epithelium. To evaluate the proliferative activity of the human skin before and after expansion, we performed an autoradiographic study and a densitometric analysis on sections of skin biopsy from 11 patients. The results of the cellular kinetic study showed that expansion induces an increase in the epidermal proliferative activity. On the contrary, the densitometric analysis did not show a parallel increase of the proliferating cells after expansion. This discrepancy is discussed in terms of the modified morphology of the tissue. The proliferative activity of skin in the back region increases more than in that of the neck. Preliminary results have shown that the proliferative activity increases with time of expansion in days. The presence of a low percentage of cells with altered DNA content indicates, at least over the short term, the absence of dysplastic processes in expanded skins.

Adolescent↗
PubMed1990

Ibopamine in the treatment of mild chronic heart failure in elderly patients. A double-blind, placebo-controlled study.

This double-blind, randomized, multicenter clinical study assessed the efficacy and safety of ibopamine 100 mg t.i.d. as monotherapy vs. placebo in 52 patients with mild chronic heart failure aged over 60 years during a 12-week treatment period. Ibopamine produced a statistically significant increase in exercise tolerance and reduction in fatigue during effort compared to placebo. A trend towards decreased requirement of concomitant diuretic therapy was noted in the ibopamine-treated group. Ibopamine was well tolerated throughout the study. This study indicated that ibopamine is an effective and safe agent as monotherapy in the treatment of mild chronic heart failure in elderly patients.

Aged↗
PubMed1989

Spirochetes in the spleen of a patient with chronic Lyme disease.

A 54-year-old man had intermittent evening fever, arthralgia, transient erythematous macular eruption on the skin, and splenomegaly of two year's duration. Immunofluorescence tests for Borrelia burgdorferi serum antibodies had positive results, but G-penicillin treatment was ineffective. Splenectomy with lymph node biopsy was performed to rule out lymphoproliferative disorders. Borrelia-like spirochetes were identified histologically in the spleen; this finding was consistent with persistence of B. burgdorferi organisms in inner organs in chronic Lyme disease.

Borrelia↗
PubMed1985

Left ventricular thrombus and myocardial infarction.

The aim of our study was to determine whether a relationship existed between echocardiographic evidence of left ventricular thrombus (LVT) and clinical course of myocardial infarction. We followed 143 patients who had had typical myocardial transmural infarction (82 with "anterior") and 61 with "inferior" myocardial infarction) over a three month period. Incidence of LVT, detected by Two-Dimensional Echocardiography (TDE) was significantly greater in subjects affected by "anterior" myocardial infarction (p less than 0.05). Furthermore, the occurrence of LVT was more frequent in the presence of left ventricular a-, dys-kinesis detected by TDE (p less than 0.01). No significant relationship was demonstrated either with the occurrence of severe ventricular arrhythmias (Lown 3-4-5) or with an abnormal stressing test performance. Thus certain clinical and laboratory features such as anterior site of infarction, higher serum level of CPK and CPK-MB and severe alterations of left ventricular kinesis proved to be useful in identifying a subset of patients most likely to have LVT who may benefit from early anticoagulant therapy.

Angina Pectoris↗
PubMed1984

Depression of lymphocyte reactivity by serum from patients with dilated cardiomyopathy.

We have investigated the presence of serum factors (serum inhibitory factor and rosette inhibitory factor) which inhibit the blastogenic response to phytohemagglutinin and E-rosette function of normal lymphocytes in patients affected with dilated cardiomyopathy. We found them to be present in significantly higher levels with respect to a "control disease" group (P less than 0.05) and normal subjects (P less than 0.02). Furthermore, serum inhibitory factors were significantly correlated to the functional class of cardiac failure as evaluated according to the New York Heart Association functional classification (P less than 0.05). There was no correlation between serum factors and other immunological parameters investigated (serum IgG, IgA, IgM, C3 and C4 concentrations, alpha-2-macroglobulin levels). Serum inhibitory factors may affect lymphocyte subpopulations, accounting for a T-suppressor functional defect correlated with greater severity of the disease.

Adolescent↗
PubMed1982

[Evaluation of various cardiovascular parameters during the intravenous administration of ranitidine].

In this paper we evaluated whether a block of cardiac H2 histamine receptors by ranetidine could modify some non-invasive indices of cardiac function: PEP/LVET, heart rate, blood pressure. Five healthy volunteers underwent studies in baseline conditions and 5, 10, 15, 30, 45 minutes following i.v. injections of 1, 5 m/g Kg of ranitidine. None of the studied parameters showed any significant variation at the various time intervals. Ranetidine does not appear to alter the cardiovascular function at the dose we used.

Adult↗
PubMed1982

[Comparative evaluation of the effects of intravenous administration of cimetidine and ranitidine on several cardiovascular parameters].

We have compared the effects of intravenous administration of cimetidine and ranetidine on some cardiovascular parameters. Five healthy volunteers received both cimetidine (3, 5 mg/Kg) and ranetidine (1, 5 mg/Kg). Heart rate, blood pressure and PEP/LVET were recorded at baseline and 5, 10, 30, 45 minutes after administration of both drugs. Intravenous administration of cimetidine and ranetidine did not induce any significant alterations in cardiovascular variables.

Adult↗
PubMed1982

Muscle tissue electrolytes in burned subjects.

In a group of patients with burns covering at least 20 per cent of their body surface area (BSA), extracellular electrolytes and acid-base status and intracellular electrolytes and nitrogen (muscle needle biopsy) were measured both in the early phase (12-24 hours) and 7-14 days after burn injury. In the acute burn phase, extracellular electrolyte and acid-base disturbances are uncommon, while intracellular data shows increase of muscle sodium, decrease of muscle potassium and magnesium and normal muscle cell nitrogen. In the later burn phase, despite an adequate fluid, electrolyte and protein-calorie supply, the changes of electrolytes appear to be uncorrected; no decrease of muscle cell nitrogen is found. Our data could suggest that defects of the sodium-potassium pump in the cell membrane, which are thought to be the cause phase of burns, do not ameliorate with adequate fluid and protein-calorie intake; however, a persistent muscle potassium depletion is also consistent with a reduction of cell "capacity' for potassium, possibly due to muscle protein catabolism, although muscle cell protein values do not show a significant reduction.

Acid-Base Equilibrium↗