Biomedical subjects
Publications and source records attributed to A B Asrian.
A model has been developed for screening atypical tranquilizers, which is based on the intrinsic property of mice and rats to avoid the brightly lit part of a chamber and on the effect of "optic precipice". The model enables one not only to select anxiolytic agents, but to differentiate them as atypical and classical tranquilizers.
Some aspects of the anxiolytic action of buspirone were investigated by differentiating fear from anxiety. Buspirone showing anxiolytic and antineurotic action in the models of anxiety and conflicting situation was demonstrated to be inactive in the model of fear of falling down from the elevated cross-shaped labyrinth. The antiamnestic effect of buspirone was revealed in the electroshock amnesia model. It is assumed that serotonin receptors are possibly responsible both for the anxiety and for memory processes.